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Acquired resistance to cancer therapies can develop due to kinase rewiring. Here, using a broad-spectrum chemical probe, the authors perform kinome screening and identify CDK6-mediated accumulation of cancer stem cells as a driver of lenvatinib (multitargeted tyrosine kinase inhibitor) resistance in hepatocellular carcinoma.

Bacteria of the genus Streptomyces have complex life cycles involving cellular differentiation and multicellular structures that have never been observed in archaea. Here, the authors show that several halophilic archaea display a life cycle resembling that of Streptomyces bacteria, undergoing cellular differentiation into mycelia and spores.

Active cell contraction drives hole nucleation, fracture and crack propagation in a tissue monolayer through a process reminiscent of dewetting thin films.

Rational engineering of interfacial structure is of great interest but it is challenging to construct active dual interfaces. Here, the authors report a strategy to establish stable dual active-interfaces resorting to the boosted oxygen spillover from ceria islets, showing high activity toward the water-gas shift reaction.

Ferroptosis is a novel form of regulated cell death associated with lipid oxidation. Here, the authors demonstrate that the proferroptosis signal is activated and drives vascular aging by inducing senescence in vascular smooth muscle cells.

Adhesion GPCRs involved in cell and matrix interactions signal through a distinct self-cleavage, self-activation mechanism.

New analyses reveal that TERRA transcripts arising from the subtelomeric pseudoautosomal (PAR) region of sex chromosomes nucleate pairing of X alleles in mouse ES cells.

Cancer stem cells contribute to breast cancer metastasis and recurrence. Here the authors show that TRIB3 enhances breast cancer stemness through interaction with AKT to promote FOXO1 stability, which then increases SOX2 activity.

It is shown that gold and several similar close-packed face-centred cubic and hexagonal metals can be vitrified, which breaks the limitation of the glass-forming ability of matter.

Severe acne is a common skin disease characterized by chronic inflammation and potential scarring. Here, the authors have identified genetic variants at two loci associated with severe acne and provide insight into the genetic architecture and biological pathways underlying the disease.

Accurate organ at risk (OAR) segmentation is critical to reduce the radiotherapy post-treatment complications. Here, the authors develop an automated OAR segmentation system to delineate a comprehensive set of 42 H&N OARs.

Inhibitor of differentiation 1 (ID1) has been described as a cancer-promoting factor and also involved in the formation of an immunosuppressive tumor microenvironment. Here the authors report that ID1-expressing tumor associated macrophages favor colorectal cancer progression by promoting cancer cell stemness and CD8⁺ T cell exclusion.

In this work, the authors develop a platform that leverages extracellular vesicles to measure drug–target engagement and apply it to monitor the outcomes of targeted treatments in lung cancer patients.

Barreby et al. identify a distinct subpopulation of human resident liver myeloid cells that expresses factors that act in a protective fashion against oxidative stress associated with NAFLD.

The authors report Bose–Einstein condensation of a two-magnon bound state in Na₂BaNi(PO₄)₂. This should stimulate further work on these types of geometrically frustrated materials.

Mikania micrantha is an extremely fast-growing invasive plant species that can cause serious damage to natural ecosystems. Here, the authors assemble its chromosome-scale reference genome and explore possible mechanisms that contribute to its rapid growth.

The jujube is a major dry fruit crop in China and is commonly used for medicinal purposes. Here the authors sequence the genome and transcriptome of the most widely cultivated jujube cultivar, Dongzao, and highlight the genetic and molecular basis of agronomically important jujube traits, such as vitamin C content.

Quantum spin Hall materials hold great potential for future nanoelectronics. Here, authors synthesize a potential host system — monolayer ZrTe₅ — and demonstrate it possesses a band gap wide enough for potential room-temperature applications.

2D Weyl semimetals are spin-polarized analogues of graphene that promise access to various topological properties of matter. Here, the authors evidence spin-polarized Weyl cones, Weyl nodes, and Fermi strings in monolayer bismuthene.

Inhibition of immunocyte infiltration and activation has been suggested to ameliorate hepatic inflammation and fibrosis in nonalcoholic steatohepatitis. Here, the authors show PirB/LILRB2 regulates the migration of macrophages during NASH by binding with ANGPTL8, which is involved in the regulation of NASH development.

Genome-wide association and fine-mapping analyses in ancestrally diverse populations implicate candidate causal genes and mechanisms underlying type 2 diabetes. Trans-ancestry genetic risk scores enhance transferability across populations.

Hard carbon is regarded as a promising negative electrode for Na-ion batteries but suffers from low initial Coulombic efficiency (ICE). Here, the authors identify the time-dependent ion pre-desolvation on the nanopore of hard carbons, which remarkably improves the ICE by simply extending the aging time.

The discovery of biomarkers remains challenging owing to a lack of methods sensitive enough to identify such rare molecules. Now, by simultaneously exploiting the catalysis and affinity of a DNAzyme, candidate biomarkers with low abundance in cancers can be pulled down for identification and validation.

170 million people worldwide are chronically infected with hepatitis C virus (HCV), which is the leading cause of cirrhosis in North America. Many patients are not cured by the current recommended treatment regime, with patients of European ancestry having a higher probability of being cured than those of African ancestry. Here, a genetic polymorphism near the IL28B gene is found to be associated with a better response to treatment; it occurs with higher frequency in European populations.

Plasmonic hydrogen sensors have limited sensitivity due to broad spectral features. Here, the authors use a particle swarm optimization algorithm to inversely design a plasmonic metasurface based on a periodic array of Pd nanoparticles, and demonstrate hydrogen detection limit of 250 ppb.

Electrochemiluminescence (ECL) plays a key role in analysis and sensing but its application is limited by a lack of highly tunable luminophores. Here, the authors demonstrate the design of high efficient ECL luminophores of covalent organic frameworks (COFs) in aqueous media by simultaneously restricting the donor and acceptor to the COFs’ electron configurations and constructing charge transport networks through olefin linkages.

How to curb climate change is uncertain, in part because determination of allowable emissions depends on models with low accuracy. Here the authors re-analyze climate-carbon feedbacks and find that CO₂ emissions could be 9 ± 7% higher and still meet Paris Agreement goals.

In this triple-arm, placebo-controlled phase 3 trial, first-line treatment of patients with extensive-stage small-cell lung cancer with the anti-PD-L1 benmelstobart, tyrosine kinase inhibitor anlotinib and chemotherapy (CT) showed improved survival outcomes compared with anlotinib and CT or CT alone.

In a phase 3 randomized controlled trial comparing secondary cytoreduction plus chemotherapy versus chemotherapy alone in patients with relapsed ovarian cancer, the coprimary endpoint of overall survival was not statistically different, but in a prespecified sensitivity analysis adjusted for patients who underwent crossover surgery following tumor relapse, there was an increase in overall survival.

Accumulation of intermittent solar energy using secondary batteries is an appealing solution for future power sources. Here, the authors propose a device comprising of perovskite solar cells and aqueous zinc metal batteries connected via the sandwich joint electrode method.

Maximizing the electromechanical response is crucial for developing piezoelectric devices. Here, the authors demonstrate a giant electric-field-induced strain and its origin in alkali niobate epitaxial thin films with self-assembled planar faults.

Tumor-associated macrophages support an immunosuppressive tumor microenvironment. Di Conza et al. uncover how IRE1–XBP1 and IRE1−STAT3 endoplasmic reticulum stress responses pathways are engaged by tumor-derived lipids to orchestrate pro-tumorigenic features and survival in tumor-associated macrophages.

Tough hydrogels capable of efficient mechanical energy dissipation are difficult to be patterned and/or printed which limits their application. Here the authors show a one-step, biocompatible and general strategy to prepare tough soft hydrogels with high-resolution 2D/3D microstructures quickly under mild conditions.

One major challenge for antiferromagnetic spintronics is how to control the antiferromagnetic state. Here Jani et al. demonstrate the reversible ionic control of the room-temperature magnetic anisotropy and spin reorientation transition in haematite, via the incorporation and removal of hydrogen.

Adsorption of molecules at surfaces is at the basis of many processes in chemistry. Here the authors propose an approach to determine the adsorption energies of different chemical species on a variety of solid surfaces based on fundamental and accessible properties of adsorbate and surface atoms.

Structural variants (SVs) in human genomes contribute diversity and diseases. Here, the authors use a multi-platform strategy to generate haplotype-resolved SVs for three human parent–child trios.