Nature Search

Personalized risk stratification in colorectal cancer via PIANOS system

Current prognostic biomarkers for colorectal cancer (CRC) tend to lack generalisability across different cohorts and platforms. Here, the authors introduce PIANOS, a classifier for stratifying CRC patients into distinct risk groups across different platforms and cohorts, which allows predicting clinical outcomes and therapies.

Du Cai
Haoning Qi
Xiaojian Wu
ResearchOpen Access16 Jul 2025
Nature Communications

Volume: 16, P: 1-18
FOXP genes regulate Purkinje cell diversity and cerebellar morphogenesis

The Li lab mapped molecularly distinct Purkinje cell (PC) subtypes in 3D and linked them to adult cerebellar architecture. They found that Foxp1/Foxp2 are essential for PC diversity and that Foxp1⁺ PCs are required for the formation of the cerebellar hemisphere.

Nagham Khouri-Farah
Qiuxia Guo
James Y. H. Li
ResearchOpen Access18 Aug 2025
Nature Neuroscience

Volume: 28, P: 2022-2033
Balancing surface adsorption and diffusion of lithium-polysulfides on nonconductive oxides for lithium–sulfur battery design

Metal oxides can suppress detrimental polysulfide shuttling in lithium-sulfur batteries, however selection criteria for oxide materials are still lacking. Here, the authors investigate polysulfide adsorption and diffusion on metal oxides and propose selection criteria based on balancing these two effects.

Xinyong Tao
Jianguo Wang
Yi Cui
ResearchOpen Access05 Apr 2016
Nature Communications

Volume: 7, P: 1-9
Correction: Corrigendum: Sirtuin1 protects endothelial Caveolin-1 expression and preserves endothelial function via suppressing miR-204 and endoplasmic reticulum stress

Modar Kassan
Ajit Vikram
Kaikobad Irani
Amendments and CorrectionsOpen Access10 Apr 2017
Scientific Reports

Volume: 7, P: 1
A clinically applicable AI system for detection and diagnosis of bone metastases using CT scans

Interpreting bone metastases (BMs) from computed tomography (CT) images remains challenging. Here, the authors develop an AI-based Bone Lesion Detection System - BLDS - and validate it in a cohort of 2,518 patients across five hospitals, showing highly sensitive and accurate performance for BM detection from CT scans.

Yun Zhang
Jiao Li
Chuanmiao Xie
ResearchOpen Access13 May 2025
Nature Communications

Volume: 16, P: 1-15
Deficiency of endothelial sirtuin1 in mice stimulates skeletal muscle insulin sensitivity by modifying the secretome

Endothelial Sirtuin1 downregulation in metabolic disorders causes vascular dysfunction and inflammation. Here, the authors show that deficiency of endothelial Sirtuin1, while having deleterious effects on the vasculature, stimulates skeletal muscle insulin sensitivity and improves glucose disposal.

Qiuxia Li
Quanjiang Zhang
Kaikobad Irani
ResearchOpen Access11 Sept 2023
Nature Communications

Volume: 14, P: 1-17
Author Correction: Cytoplasmic Endonuclease G promotes nonalcoholic fatty liver disease via mTORC2-AKT-ACLY and endoplasmic reticulum stress

Wenjun Wang
Junyang Tan
Qinghua Zhou
Amendments and CorrectionsOpen Access21 Aug 2024
Nature Communications

Volume: 15, P: 1
Author Correction: Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes

Cui-Ping Yang
Xiaoyan Li
Xiong-Jian Luo
Amendments and CorrectionsOpen Access16 Nov 2018
Nature Communications

Volume: 9, P: 1
Fasting shapes chromatin architecture through an mTOR/RNA Pol I axis

Al-Refaie et al. show that fasting induces spatial reorganization of chromatin and formation of chromatin rings in an mTORC1- and RNA Pol I-dependent manner in the C. elegans intestine.

Nada Al-Refaie
Francesco Padovani
Daphne S. Cabianca
ResearchOpen Access19 Sept 2024
Nature Cell Biology

Volume: 26, P: 1903-1917
Photothermal therapy of tuberculosis using targeting pre-activated macrophage membrane-coated nanoparticles

Tuberculosis is a major global health issue. Here the authors report Mycobacterium-pre-activated macrophage membrane-coated photothermal nanoparticles for targeted tuberculous granuloma and pathogen dual imaging and antibacterial photothermal therapy.

Bin Li
Wei Wang
Yuhui Liao
Research21 Feb 2024
Nature Nanotechnology

Volume: 19, P: 834-845
Intelligent fault diagnosis of rotating machinery based on improved hybrid dilated convolution network for unbalanced samples

Qianqian Zhang
Caiyun Hao
Weihuang Liu
ResearchOpen Access23 Apr 2025
Scientific Reports

Volume: 15, P: 1-15
Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy

Rap1 is a telomeric protein that is highly expressed in cancers. Here, the authors show that Rap1 interacts with several DNA repair proteins independent of its telomere function to enhance DNA repair and that its deficiency leads to accelerated tumorigenesis, but enhanced sensitivity to genotoxic stress.

Ekta Khattar
Kyaw Ze Ya Maung
Vinay Tergaonkar
ResearchOpen Access13 Dec 2019
Nature Communications

Volume: 10, P: 1-14
Cytoplasmic Endonuclease G promotes nonalcoholic fatty liver disease via mTORC2-AKT-ACLY and endoplasmic reticulum stress

Endonuclease G is known to translocate to the nucleus during apoptosis, but less is known about its role in the cytosol. Here, the authors show that cytoplasmic endonuclease G activates mTORC2 signaling and ER stress to promote NAFLD in female mice.

Wenjun Wang
Junyang Tan
Qinghua Zhou
ResearchOpen Access04 Oct 2023
Nature Communications

Volume: 14, P: 1-16
Urinary sediment microRNAs can be used as potential noninvasive biomarkers for diagnosis, reflecting the severity and prognosis of diabetic nephropathy

Qiuxia Han
Youcai Zhang
Hanyu Zhu
ResearchOpen Access30 Jun 2021
Nutrition & Diabetes

Volume: 11, P: 1-7
Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes

More than 100 risk loci for schizophrenia have been identified by genome-wide association studies. Here, the authors apply an integrative genomic approach to prioritize risk genes and validate GLT8D1 and CSNK2B as candidate causal genes by in vitro studies in neural stem cells.

Cui-Ping Yang
Xiaoyan Li
Xiong-Jian Luo
ResearchOpen Access26 Feb 2018
Nature Communications

Volume: 9, P: 1-16
Identification of mangiferin as a potential Glucokinase activator by structure-based virtual ligand screening

Qiuxia Min
Xinpei Cai
Jiachun Chen
ResearchOpen Access20 Mar 2017
Scientific Reports

Volume: 7, P: 1-9
Vascular microRNA-204 is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating Sirtuin1

Commensal bacteria, the vast majority of which reside in the gut, are involved in development of many diseases, including atherosclerotic vascular disease. Here the authors show that these bacteria remotely increase expression of vascular microRNA-204, which targets Sirt1 in the endothelium to impair endothelial function.

Ajit Vikram
Young-Rae Kim
Kaikobad Irani
ResearchOpen Access02 Sept 2016
Nature Communications

Volume: 7, P: 1-9
Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12

Weinian Shou
Bahman Aghdasi
Martin M. Matzuk
Research29 Jan 1998
Nature

Volume: 391, P: 489-492
Silicon addition improves plant productivity and soil nutrient availability without changing the grass:legume ratio response to N fertilization

Danghui Xu
Tianpeng Gao
Renyi Zhang
ResearchOpen Access24 Jun 2020
Scientific Reports

Volume: 10, P: 1-9
Determination of behavior of catalpol hexapropionate in simulated gastric conditions by UPLC–ESI–HRMS

Xiaodong Cheng
Qiuxia Zhang
Guoqing Wang
ResearchOpen Access07 Jul 2020
Scientific Reports

Volume: 10, P: 1-7
A novel taxane SB-T-101141 triggers a noncanonical ferroptosis to overcome Paclitaxel resistance of breast cancer via iron homeostasis-related KHSRP

Xiaomei Zhang
Ying Fang
Haihe Wang
ResearchOpen Access19 May 2025
Cell Death & Disease

Volume: 16, P: 1-17
Sirtuin1 protects endothelial Caveolin-1 expression and preserves endothelial function via suppressing miR-204 and endoplasmic reticulum stress

Modar Kassan
Ajit Vikram
Kaikobad Irani
ResearchOpen Access09 Feb 2017
Scientific Reports

Volume: 7, P: 1-10
Z/Ce@hemin enzymes with enhanced peroxidase activity for monitoring and screening the oxidative stress models of Parkinson’s disease

Li Lei
Xiuli Chen
Chunlin Zhang
ResearchOpen Access01 Mar 2025
npj Parkinson's Disease

Volume: 11, P: 1-10
Development of the coupled smoothing technique λS-FEM for mechanical analysis of twist drills

Qiuxia Fan
Qianqian Hua
Lei Xu
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-26
Application and mechanism of anticancer peptides in organoid models of intrahepatic cholangiocarcinoma

Xuekai Hu
Yue Zhang
Jia Yao
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-14
A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis

Jieruo Gu, Jianjun Liu and colleagues report the results of a genome-wide association study of ankylosing spondylitis in Han Chinese. They identify two new susceptibility loci for this inflammatory disease and confirm strong associations with variants in the HLA-B region.

Zhiming Lin
Jin-Xin Bei
Jieruo Gu
Research04 Dec 2011
Nature Genetics

Volume: 44, P: 73-77
Nonlinear relationships between the triglyceride glucose-body mass index and cardiovascular disease in middle-aged and elderly women from NHANES (1999–2018)

Chunxue Li
Qiuxia Lin
Lin Li
ResearchOpen Access31 Mar 2025
Scientific Reports

Volume: 15, P: 1-10
Gastrointestinal absorption and its regulation of hawthorn leaves flavonoids

Junwei Chow
Xiaolei Yang
Guo Ma
ResearchOpen Access03 Jan 2025
Scientific Reports

Volume: 15, P: 1-20
A dual-functional electrolyte additive displaying hydrogen bond fusion enables highly reversible aqueous zinc ion batteries

Aqueous zinc ion batteries represent promising next-generation energy storage systems, but unwanted side reactions such as hydrogen evolution and zinc dendrite formation can significantly impact their Coulombic efficiency and lifespan. Here, dimethyl sulfoxide and nanodiamond additives are introduced to a ZnSO₄ electrolyte, effectively inhibiting side reactions and dendrite formation through hydrogen bond fusion, and enabling exceptional cycling stability for over 1500 h at 1 mA cm⁻².

Qiuxia Zhang
Xuan Gao
Hongdong Li
ResearchOpen Access08 Aug 2024
Communications Chemistry

Volume: 7, P: 1-9
An Equation Based on Fuzzy Mathematics to Assess the Timing of Haemodialysis Initiation

Ying Liu
Degang Wang
Hongli Lin
ResearchOpen Access10 Apr 2019
Scientific Reports

Volume: 9, P: 1-11
The schizophrenia-associated missense variant rs13107325 regulates dendritic spine density

Shiwu Li
Changguo Ma
Xiong-Jian Luo
ResearchOpen Access02 Sept 2022
Translational Psychiatry

Volume: 12, P: 1-12
miR-340-FHL2 axis inhibits cell growth and metastasis in ovarian cancer

Zheng Huang
Qiuxia Li
Jianmin Wu
ResearchOpen Access08 May 2019
Cell Death & Disease

Volume: 10, P: 1-16
Differential early diagnosis of benign versus malignant lung cancer using systematic pathway flux analysis of peripheral blood leukocytes

Jian Li
Xiaoyu Li
Qi Mei
ResearchOpen Access24 Mar 2022
Scientific Reports

Volume: 12, P: 1-14
Sirtuin 1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel

Intracellular trafficking of the voltage-gated cardiac Na⁺ channel Nav1.5 is regulated by lysine deacetylation mediated by Sirt1, thereby affecting sodium current and cardiac electrical activity.

Ajit Vikram
Christopher M Lewarchik
Kaikobad Irani
Research13 Feb 2017
Nature Medicine

Volume: 23, P: 361-367
Comprehensive evaluation of the mechanism of human adipose mesenchymal stem cells ameliorating liver fibrosis by transcriptomics and metabolomics analysis

Guibao Ji
Zilong Zhang
Chuanjiang Li
ResearchOpen Access28 Aug 2024
Scientific Reports

Volume: 14, P: 1-15
Overexpression of SerpinE2/protease nexin-1 Contribute to Pathological Cardiac Fibrosis via increasing Collagen Deposition

Xuelian Li
Dandan Zhao
Hongli Shan
ResearchOpen Access23 Nov 2016
Scientific Reports

Volume: 6, P: 1-12
Molecular characterization and analysis of high-level multidrug-resistance of Shigella flexneri serotype 4s strains from China

Chaojie Yang
Peng Li
Hongbin Song
ResearchOpen Access04 Jul 2016
Scientific Reports

Volume: 6, P: 1-11
Taxonomic response of bacterial and fungal populations to biofertilizers applied to soil or substrate in greenhouse-grown cucumber

Jiajia Wu
Zhaoai Shi
Yuan Li
ResearchOpen Access02 Nov 2022
Scientific Reports

Volume: 12, P: 1-16
GSK3β mediates the spatiotemporal dynamics of NLRP3 inflammasome activation

Suyavaran Arumugam
Yanqin Qin
Xinshou Ouyang
Research27 Apr 2022
Cell Death & Differentiation

Volume: 29, P: 2060-2069
Global soil moisture data fusion by Triple Collocation Analysis from 2011 to 2018

Qiuxia Xie
Li Jia
Guangcheng Hu
ResearchOpen Access11 Nov 2022
Scientific Data

Volume: 9, P: 1-19
MicroRNA-204 promotes vascular endoplasmic reticulum stress and endothelial dysfunction by targeting Sirtuin1

Modar Kassan
Ajit Vikram
Kaikobad Irani
ResearchOpen Access24 Aug 2017
Scientific Reports

Volume: 7, P: 1-11
Microbiota-governed microRNA-204 impairs endothelial function and blood pressure decline during inactivity in db/db mice

Ravinder Reddy Gaddam
Veronica Peotta Jacobsen
Ajit Vikram
ResearchOpen Access22 Jun 2020
Scientific Reports

Volume: 10, P: 1-14
Growth hormone treatment in pre-pubertal short Chinese children with chronic kidney disease prior to transplantation

Xiaoshan Tang
Qiuxia Chen
Hong Xu
Research20 Dec 2022
Pediatric Research

Volume: 94, P: 268-274

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