Nature Search

PI3Kβ controls immune evasion in PTEN-deficient breast tumours

A mouse model of invasive breast cancer in which Pten and Trp53 are simultaneously inactivated links PTEN loss with STAT3 activation and indicates that immune escape in PTEN-null tumours is mediated by PI3Kβ.

Johann S. Bergholz
Qiwei Wang
Jean J. Zhao
Research19 Apr 2023
Nature

Volume: 617, P: 139-146
Generation and characterization of neutralizing antibodies against M1R and B6R proteins of monkeypox virus

This study identifies monoclonal antibodies A138 and B026 targeting MPXV proteins M1R and B6R. Both antibodies exhibit neutralization of MPXV and VACV, and their combination enhances protective efficacy in mice, supporting a dual-targeting strategy.

Yuanyuan Qu
Wanbo Tai
Gong Cheng
ResearchOpen Access01 Apr 2025
Nature Communications

Volume: 16, P: 1-16
Selective identification of epigenetic regulators at methylated genomic sites by SelectID

The authors introduce SelectID, an approach combining CRISPR-guided targeting with methylation-sensitive labeling to identify proteins interacting with methylated repetitive sequences. They suggest that CHD4 directly binds young LINE-1 retrotransposons, suppressing their activity.

Wenchang Qian
Penglei Jiang
Pengxu Qian
ResearchOpen Access18 Apr 2025
Nature Communications

Volume: 16, P: 1-14
AMPK-dependent phosphorylation of the GATOR2 component WDR24 suppresses glucose-mediated mTORC1 activation

Dai et al. show that in response to low glucose levels, AMP-activated protein kinase-mediated phosphorylation of WDR24, a component of the GATOR2 complex, leads to suppression of mTORC1 activation.

Xiaoming Dai
Cong Jiang
Wenyi Wei
Research02 Feb 2023
Nature Metabolism

Volume: 5, P: 265-276
Impacts of renewable energy resources on the weather vulnerability of power systems

Renewable energy sources (RESs) are weather sensitive, raising questions about the vulnerability of high-penetration weather-dependent RES grids during extreme weather events. Here the authors find that blackout intensities and extreme weather vulnerability are mitigated in high-penetration weather-dependent RES grids.

Jin Zhao
Fangxing Li
Qiwei Zhang
Research21 Oct 2024
Nature Energy

Volume: 9, P: 1407-1414
Single-step discovery of high-affinity RNA ligands by UltraSelex

A method called UltraSelex for identifying RNA aptamers has been developed. UltraSelex is noniterative and can combine biochemical partitioning, high-throughput sequencing and computational signal-to-background rank modeling of hits in approximately 1 day.

Yaqing Zhang
Yuan Jiang
Andres Jäschke
Research31 Mar 2025
Nature Chemical Biology

Volume: 21, P: 1118-1126
Nuclear SREBP2 condensates regulate the transcriptional activation of lipogenic genes and cholesterol homeostasis

Nuclear SREBP2 forms nuclear condensates through its N-terminal intrinsically disordered region, which is essential for the transcriptional activation of lipogenic genes.

Mengqiang Xu
Shi-You Jiang
Wei Qi
Research20 May 2025
Nature Metabolism

Volume: 7, P: 1034-1051
Graphdiyne oxide nanosheets display selective anti-leukemia efficacy against DNMT3A-mutant AML cells

DNA methyltransferase 3A, a mutated gene associated with hematologic malignancies in age-related clonal haematopoiesis lacks targeted therapies. Here, the authors screen carbon nanomaterials and find graphdiyne oxide binds to mutant cells and disrupts cellular processes with a therapeutic effect in vitro and in vivo.

Qiwei Wang
Ying Liu
Pengxu Qian
ResearchOpen Access26 Sept 2022
Nature Communications

Volume: 13, P: 1-16
S6K1-mediated phosphorylation of PDK1 impairs AKT kinase activity and oncogenic functions

The direct upstream regulation of PDK1 is not fully understood. Here the authors demonstrate that S6K1 directly phosphorylates PDK1 to inhibit AKT kinase activity and its ability to drive tumourigenesis.

Qiwei Jiang
Xiaomei Zhang
Jianping Guo
ResearchOpen Access22 Mar 2022
Nature Communications

Volume: 13, P: 1-14
Discovery of the major 15–30 nt mammalian small RNAs, their biogenesis and function

The authors uncover the major 15-30 nt mouse and human small RNAs (sRNAs), which mainly end with 2’,3’-cyclic phosphate, and show that many of these sRNAs can be generated by Angiogenin or RNase 4 and function in Ago2 complex as miRNAs.

Hejin Lai
Ning Feng
Qiwei Zhai
ResearchOpen Access18 Sept 2023
Nature Communications

Volume: 14, P: 1-16
Heat-inactivated Bifidobacterium adolescentis ameliorates colon senescence through Paneth-like-cell-mediated stem cell activation

Here, Wang et al. show that heat-inactivated Bifidobacterium adolescentis mediates maintenance of host intestinal barrier through intestinal stem cells activation, which can potentially have translational implications for alleviation of colon senescence and related diseases.

Yadong Qi
Jiamin He
Liangjing Wang
ResearchOpen Access30 Sept 2023
Nature Communications

Volume: 14, P: 1-19
STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer

PARP inhibitor (PARPi) therapy has demonstrated only modest efficacy in advanced breast cancer with BRCA mutations. Here the authors show that, by suppressing PARPi-triggered DNA damage and reducing dsDNA production in BRCA1-deficient breast tumor cells, tumor associated macrophages contribute to PARPi resistance, that can be overcome by STING agonism.

Qiwei Wang
Johann S. Bergholz
Jean J. Zhao
ResearchOpen Access31 May 2022
Nature Communications

Volume: 13, P: 1-17
Author Correction: SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation

Pan Pan
Miaomiao Shen
Jianguo Wu
Amendments and CorrectionsOpen Access31 Aug 2021
Nature Communications

Volume: 12, P: 1
SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation

SARS-CoV-2 infection has been shown to drive NLRP3 inflammasome activation and thereby cytokine storm, but how it does so is unclear. Here the authors show that the viral N protein can bind to NLRP3, resulting in enhanced interaction with ASC and thereby with the NLRP3 inflammasome.

Pan Pan
Miaomiao Shen
Jianguo Wu
ResearchOpen Access02 Aug 2021
Nature Communications

Volume: 12, P: 1-17
Mitochondrial long non-coding RNA GAS5 tunes TCA metabolism in response to nutrient stress

The localization of long non-coding RNAs plays a vital role in regulating cellular processes. In addition to compiling a database of organelle-associated lncRNAs, Sang et al. identify a role for the lncRNA GAS5 in regulating tricarboxylic acid cycle enzymes during nutrient stress.

Lingjie Sang
Huai-qiang Ju
Aifu Lin
Research04 Jan 2021
Nature Metabolism

Volume: 3, P: 90-106
Infection, pathology and interferon treatment of the SARS-CoV-2 Omicron BA.1 variant in juvenile, adult and aged Syrian hamsters

Lunzhi Yuan
Huachen Zhu
Ningshao Xia
ResearchOpen Access18 Oct 2022
Cellular & Molecular Immunology

Volume: 19, P: 1392-1399
Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs

Zhang et al. report that tRNA methyltransferase Dnmt2 is required for sperm small-non-coding-RNA-mediated transmission of paternal metabolic disorders to the offspring.

Yunfang Zhang
Xudong Zhang
Qi Chen
Research25 Apr 2018
Nature Cell Biology

Volume: 20, P: 535-540
Carrier screening for spinal muscular atrophy with a simple test based on melting analysis

Zhongmin Xia
Yulin Zhou
Qiwei Guo
Research15 Feb 2019
Journal of Human Genetics

Volume: 64, P: 387-396
Spatiotemporal evolution and convergence patterns of urban carbon emission efficiency in China

Chuanqing Wu
Heshun Deng
Qiwei Xia
ResearchOpen Access15 May 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-13
Gpnmb secreted from liver promotes lipogenesis in white adipose tissue and aggravates obesity and insulin resistance

Metabolism is tightly regulated through communication among cells and organs. Here Gong and colleagues show that a liver-secreted factor, Gpnmb, promotes lipogenesis in adipose tissue and worsens metabolic dysfunctions during diet-induced obesity, whereas its inhibition reduces weight gain and insulin resistance.

Xue-Min Gong
Yun-Feng Li
Bao-Liang Song
Research06 May 2019
Nature Metabolism

Volume: 1, P: 570-583
The PDE4DIP-AKAP9 axis promotes lung cancer growth through modulation of PKA signalling

Mechanistic exploration of PDE4DIP in the progression of non-small cell lung cancer (NSCLC) demonstrates that PDE4DIP coordinates with AKAP9 to promotes NSCLC growth via regulating PKA/CREB signaling pathway.

Yangyang Fu
Shishun Huang
Xincheng Lu
ResearchOpen Access04 Feb 2025
Communications Biology

Volume: 8, P: 1-13
IKBKE phosphorylates and stabilizes Snail to promote breast cancer invasion and metastasis

Wei Xie
Qiwei Jiang
Jianping Guo
Research22 Jan 2022
Cell Death & Differentiation

Volume: 29, P: 1528-1540
Bifidobacterium adolescentis regulates catalase activity and host metabolism and improves healthspan and lifespan in multiple species

This study shows that dietary supplementation with B. adolescentis increases the activity of the catalase enzyme and improves the healthspan and lifespan in multiple animal models. Deletion of the catalase enzyme in worms abolished the beneficial effects of the bacterium.

Shujie Chen
Luyi Chen
Liangjing Wang
Research16 Nov 2021
Nature Aging

Volume: 1, P: 991-1001
Reduced glutathione level in the aqueous humor of patients with primary open-angle glaucoma and normal-tension glaucoma

Kota Sato
Daisuke Saigusa
Toru Nakazawa
ResearchOpen Access21 Nov 2023
npj Aging

Volume: 9, P: 1-10
Spatiotemporal manipulation of auxin biosynthesis in cotton ovule epidermal cells enhances fiber yield and quality

It has been extremely challenging to simultaneously improve both the yield and quality of cotton by conventional breeding. Extensive field trials indicate that regulated expression of an auxin biosynthesis gene in the epidermis of cotton ovules improves both the number and fineness of cotton fibers.

Mi Zhang
Xuelian Zheng
Yan Pei
Research10 Apr 2011
Nature Biotechnology

Volume: 29, P: 453-458
AMPK phosphorylates and stabilises copper transporter 1 to synergise metformin and copper chelator for breast cancer therapy

Xiaomei Zhang
Qiwei Jiang
Jianping Guo
Research17 Feb 2023
British Journal of Cancer

Volume: 128, P: 1452-1465
Inhibition of EZH2 ameliorates bacteria-induced liver injury by repressing RUNX1 in dendritic cells

Yanan Wang
Qiwei Wang
Meiling Zhu
ResearchOpen Access01 Dec 2020
Cell Death & Disease

Volume: 11, P: 1-13
Deubiquitinase USP29 promotes gastric cancer cell migration by cooperating with phosphatase SCP1 to stabilize Snail protein

Wenli Qian
Qi Li
Zhaoyuan Hou
Research24 Sept 2020
Oncogene

Volume: 39, P: 6802-6815
Identification of a novel class of RIP1/RIP3 dual inhibitors that impede cell death and inflammation in mouse abdominal aortic aneurysm models

Ting Zhou
Qiwei Wang
Bo Liu
ResearchOpen Access06 Mar 2019
Cell Death & Disease

Volume: 10, P: 1-15
SARS-CoV-2 N protein enhances the anti-apoptotic activity of MCL-1 to promote viral replication

Pan Pan
Weiwei Ge
Jianguo Wu
ResearchOpen Access09 May 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-15
C/EBPα regulates SIRT1 expression during adipogenesis

Qihuang Jin
Fang Zhang
Qiwei Zhai
Research16 Feb 2010
Cell Research

Volume: 20, P: 470-479
GPR120 induces regulatory dendritic cells by inhibiting HK2-dependent glycolysis to alleviate fulminant hepatic failure

Hongshuang Yu
Wanlin Yang
Min Jin
ResearchOpen Access16 Dec 2021
Cell Death & Disease

Volume: 13, P: 1-15
The effect of decongestion on nasal airway patency and airflow

Qiwei Xiao
Alister J. Bates
Denis J. Doorly
ResearchOpen Access13 Jul 2021
Scientific Reports

Volume: 11, P: 1-13
Moderate static magnetic fields enhance antitumor CD8⁺ T cell function by promoting mitochondrial respiration

Xiaoyan Zhu
Yan Liu
Qiwei Zhai
ResearchOpen Access03 Sept 2020
Scientific Reports

Volume: 10, P: 1-16
AHA1 upregulates IDH1 and metabolic activity to promote growth and metastasis and predicts prognosis in osteosarcoma

Diwei Zheng
Weihai Liu
Zhi Shi
ResearchOpen Access20 Jan 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-12
LncRNA expression profiling of BMSCs in osteonecrosis of the femoral head associated with increased adipogenic and decreased osteogenic differentiation

Qingyu Wang
Qiwei Yang
Yang Song
ResearchOpen Access14 Jun 2018
Scientific Reports

Volume: 8, P: 1-14
Response of tomato wilt pathogen Ralstonia solanacearum to the volatile organic compounds produced by a biocontrol strain Bacillus amyloliquefaciens SQR-9

Waseem Raza
Ning Ling
Qirong Shen
ResearchOpen Access22 Apr 2016
Scientific Reports

Volume: 6, P: 1-13
Individual-specific functional connectivity improves prediction of Alzheimer’s disease’s symptoms in elderly people regardless of APOE ε4 genotype

Analysis of individual-specific functional connectivity can differentiate between normal ageing and Alzheimer Disease and individual-specific between-network connectivity constitute a major contributor for assessing cognitive symptoms in both APOE ε4 carriers and non-carriers.

Lin Hua
Fei Gao
Zhen Yuan
ResearchOpen Access31 May 2023
Communications Biology

Volume: 6, P: 1-11
Curing the Toxicity of Multi-Walled Carbon Nanotubes through Native Small-molecule Drugs

Wei Qi
Longlong Tian
Wangsuo Wu
ResearchOpen Access06 Jun 2017
Scientific Reports

Volume: 7, P: 1-14
Hypoxia signaling in human health and diseases: implications and prospects for therapeutics

Zhen Luo
Mingfu Tian
Jianguo Wu
ReviewsOpen Access07 Jul 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-30

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