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Satellite observations over the Greenland Ice Sheet reveal a destructive mode of meltwater drainage whereby a subglacial flood induced by the rapid drainage of a subglacial lake burst through the surface, fracturing the ice sheet.

A multiancestry phenome-wide analysis of copy number variants in the UK Biobank genomes increases power to detect genetic associations with complex traits across human populations.

Authors perform an analysis of the patient data and risk factors to evaluate unfavorable outcomes and adverse events in adults with pulmonary tuberculosis treated with a 4-month rifapentine based regimen. Low rifapentine exposure was the most clinically significant risk factor for treatment failure and tuberculosis relapse.

This study examines long-term changes in species richness across tropical forests in the Andes and Amazon. Hotter, drier and more seasonal forests in the eastern and southern Amazon are losing species, while Northern Andean forests are accumulating species, acting as a refuge for climate-displaced species.

Disease heterogeneity complicates precision medicine, which focuses on single conditions and ignores shared mechanisms. Here the authors introduce ‘pan-disease’ analysis using a deep learning model on multi-organ data, identifying 11 AI-derived biomarkers that reveal new therapeutic targets and pathways, enhancing patient stratification for disease risk monitoring and drug discovery.

This study demonstrates that 16p11.2 hemideletion, a genetic deletion linked to neurodevelopmental disorders, affects male and female mice differently, altering specific striatal neuronal circuits and driving sex-specific behavioral changes.

Electrochemical hydrogenation drives a reversible conductor–insulator transition in graphene. Authors show that it is 10⁶× faster than other methods and tunable by isotope effects and lattice corrugations, enabling ionic control of 2D electronics.

The International Brain Laboratory presents a brain-wide electrophysiological map obtained from pooling data from 12 laboratories that performed the same standardized perceptual decision-making task in mice.

Amorphous phases in alkali-activated slag cement are explored using spatially resolved synchrotron X-ray techniques. Local atomic structures of individual phases show the impact of magnesium content on resistance to CO₂-induced degradation.

Multidrug efflux pumps help bacteria survive stress and promote antibiotic resistance. Here, authors define the molecular detail of an anaerobic-connected pump MdtF uncovering acid-responsive activity which may enable toxin control in certain niches.

SmartEM is a ‘smart’ pipeline for electron microscopy-based data acquisition for connectomics. In order to efficiently image large datasets, the approach involves imaging at short pixel dwell times and identifying problematic regions that are then imaged with longer dwell times and therefore higher quality.

Through next-generation spectral analysis, scientists have uncovered an evolutionary path for Wolf–Rayet stars in metal-poor environments. Characterized by hard ionizing radiation, these stars challenge current assumptions about massive star evolution.

CaMKII is a key enzyme in brain, heart, and egg cells, regulated by calcium signals. Here, authors show that charged residues in the variable linker tune CaMKII activity, a mechanism that may underlie cell type–specific responses.

Gene duplication is a key evolutionary mechanism, as initially redundant paralogues diverge over time. The authors review how adaptive and non-adaptive forces influence the evolutionary fates of gene duplicates, highlighting the importance of function–fitness relationships and gene expression dynamics.

This study demonstrates that the fastest astrophysical jets are locked to a fixed axis, whereas slower jets can precess or wobble. The findings imply that the most relativistic jets are tied to the spin axis of the black hole that launched them.

Confidence is key to decision-making, but the dynamics of confidence formation remain elusive. We show that neural populations in parietal cortex reflect the parallel processes of forming a decision and confidence in the decision.

Single-cell proteomics maps protein dynamics in the developing human brain.

Suture zones are abundant on Antarctic ice shelves and widely observed to impede fracture propagation. Here we show that fracture detainment is principally controlled by the zones’ enhanced seawater contents, reducing fracture-driving stresses by orders of magnitude and therefore greatly enhancing stability.

A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.

Delivering plasmid DNA to solid tumors is challenging since it demands more transport steps than other genetic materials. Here this group designs a hybrid lipoplex for co-delivering p53 plasmid along with MDM2 inhibitor sp141 to hepatocellular carcinoma and lung carcinoma for synergistic anti-tumor treatment.

Here they show that mitochondria-localized NEK7 couples mitochondrial complex II subunit SDHB to maintain the homeostasis of electron transport in hepatocytes, thereby impeding the progression of liver fibrosis.

An extreme flare has been seen from a supermassive black hole at redshift z = 2.6. First detected in 2018, it is 30 times brighter than similar events. The most likely cause is the shredding of a star of 30 solar masses or more.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

The corpus callosum is essential for coordinating sensorimotor, associative and executive functions. Here, the authors show a GWAS of corpus callosum morphology implicates prenatal growth pathways, immune-driven thinning, and genetic overlap with cortical and neuropsychiatric traits.

Brain-wide recordings in mice reveal that prior expectations are distributed through recurrent loops across all levels of cortical and subcortical processing.

Remote C–H bond formation via photoenzymatic hydrogen atom transfer has enabled the precise installation of remote stereocentres but is still in its infancy. Here, the authors report the photoenzymatic stereoablative enantioconvergence of γ-chiral oximes using repurposed flavin-dependent ene-reductases.

Negative data composition critically shapes machine learning robustness in sequence-based biological tasks. Training data composition and its implications are investigated on biological rule discoveries.

Climate change will decrease Arctic Sea ice and increase light, but effects on polar ecosystems remain unclear. Here, the authors predict that warming waters and prey loss will threaten cold-water fish species and severely reduce their habitat by 2060.

Meta-analyses often rely on reported precision to weigh studies. Here, the authors show that such precision can be overstated, and introduce a method that reduces the resulting bias, using sample size as an instrument for reported precision.

GRX-810, an oxide dispersion strengthened alloy, shows excellent structural performance above 1100°C and stability up to 1300 °C. Grain-size effects, additive manufacturing–induced anisotropy, and fine trigonal Y₂O₃ particles enhance creep resistance.

Examining human brain organoids and ex vivo neonatal murine cortical slices demonstrates that structured neuronal sequences emerge independently of sensory input, highlighting the potential of brain organoids as a model for neuronal circuit assembly.

Cloaking of a range of stimuli have been demonstrated in various metamaterials recently. Here, the authors report mechanical cloaking in a pentamode structure, leading to ‘unfeelability’ of a core in an elasto-mechanical core-shell system.

In this Perspective, the authors discuss reasons for the increased cardiometabolic disease risk observed in Asian populations, including nutrition, genetic factors and environmental adversity.

Spatial cell distribution within a tissue microenvironment is a rapidly advancing field. Here, authors assess three commercially available single-cell resolution spatial transcriptomics approaches (CosMx, MERFISH, and Xenium) to inform which technology outperforms for immune profiling of solid tumors using patient samples.

Sorghum is an important crop species for the African continent but the grain is difficult to digest. The authors of this study examine a previously identified sorghum mutant known for improved digestion and find that the mutant is the result of a point mutation in the seed-processing protein kafirin.

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

Post-infectious myalgic encephalomyelitis/chronic fatigue syndrome (PI-ME/CFS) is a disabling disorder, yet the clinical phenotype is poorly defined and the pathophysiology unknown. Here, the authors conduct deep phenotyping of a cohort of PI-ME/CFS patients.

Although the number of participants is important for phenotypic prediction accuracy in brain-wide association studies using functional MRI, scanning for at least 30 min offers the greatest cost effectiveness.

Hematoxylin and eosin (H&E) staining is a widely used method in histopathology, but it cannot directly inform about specific molecular markers. Here, the authors present ROSIE, a deep-learning framework that computationally imputes the expression and localisation of dozens of proteins from H&E images.

The formation of faults in lithium-ion batteries can significantly impact pack safety and performance. Pierre Lambert and colleagues propose a modelling and machine learning framework to detect these faults from the current oscillations found in parallel connected packs.