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The charge states in distant quantum dots can be coupled through an intermediate state in a third quantum dot.

The control of translation during mitosis has an important role in cancer cell biology. Here the authors report that in mitotically arrested cancer cells, redistribution of ribosomes towards upstream open reading frames results in enhanced presentation of immunogenic peptides on cancer cell surface.

Axonal injury, induced in the white matter by expansion of early tumour cells, is a key driver of glioblastoma progression.

The ability to imprint phase shifts on light lie at the basis of several classical and quantum light-based information processing primitives. Here, the authors demonstrate the phase shift of an optical field by a single quantum emitter in a waveguide, at the single photon level.

The prevalent fungal pathogen, Candida albicans, and the emerging multidrug-resistant superfungus, Candida auris, share the same initial cell wall architecture but remodel it differently in response to echinocandin-induced antifungal stress.

Bacterial large subunit assembly is rapid and intricate, involving complex RNA domain interactions. Here, authors use anti-sense oligonucleotide probing with cryo-EM to reveal early-stage domain consolidation and identify RNA foldons that guide late-stage assembly.

Rydberg atoms are appealing for sensing, atomic and quantum information studies, if they can be suitably integrated with optical devices. Towards this end, Epple et al. show that caesium-filled kagome-lattice hollow-core photonic crystal fibres provide a platform for fibre-based spectroscopy of Rydberg states.

Borosins are ribosomally encoded and posttranslationally modified peptide (RiPP) natural products featuring amide-backbone α-N-methylation. Here, the authors report the discovery and characterization of type IV borosin ‘split’ pathways encoding distinct, separate α-N-methyltransferases and precursor peptide substrates.

In cohort B of the phase 2 SWOG S1512 trial, pembrolizumab monotherapy in patients with unresectable desmoplastic melanoma elicited a complete response rate of 37% and an objective response rate of 89%, supporting a new treatment option for this tumor type.

A highly potent and selective small-molecule catalytic inhibitor of the protein lysine methyltransferase NSD2 shows therapeutic efficacy in preclinical models of KRAS-driven pancreatic cancer and lung cancer.

The electron-phonon interaction in gold and silver is weak, which leads to both their high conductivity and lack of conventional superconductivity. Here, Kumbhakar and coauthors find, using point contact spectroscopy, that the electron-phonon interaction in a nanostructured gold-silver film can be enhanced by over two orders of magnitude compared to the constituent elements.

Trapping electrons on a superfluid helium surface provides access to collective quantum phenomena and a platform for circuit quantum electrodynamics (cQED). Here, the authors demonstrate precision spatial and frequency engineering of plasmonic modes in a hybrid electron-on-helium system, opening the door towards integration of plasmon physics within future cQED-like devices.

Some cancer cells exhibit high loads of reactive iron in lysosomes, and this feature is exploited by using fentomycin-1, a newly developed small molecule, to induce ferroptosis.

Here, the authors show that giving probiotics to very low birth weight preterm babies can help reduce harmful antibiotic-resistant bacteria in the gut and support the development of a healthier microbiome.

Olfactory perception of food-derived odors influences feeding behavior, but the underlying neural pathways remain unclear. Here, the authors show that prolonged exposure to food odor suppresses food intake and body weight gain by activating an olfactory bulb–hypothalamus circuit.

Previous transport studies of graphite in strong magnetic fields have found a sequence of phase transitions with a still unresolved microscopic origin. Here the authors present ultrasound measurements enabling sharper resolution and demonstrating the thermodynamic nature of these transitions.

Polycrystalline thin films of elemental bismuth exhibit a room-temperature nonlinear transverse voltage due to geometric effects of surface electrons that is tunable and can be extended to efficient high-harmonic generation at terahertz frequencies.

In the CheckMate 7FL trial, neoadjuvant nivolumab and chemotherapy in patients with newly diagnosed, high-risk estrogen receptor-positive breast cancer led to an increased pathological complete response rate compared with neoadjuvant chemotherapy alone, and this increase was associated with immune-related biomarkers and estrogen receptor expression.

Atomic clocks are increasingly important for many applications in scientific research and technology. Here, Nicholson et al. present a series of developments allowing them to achieve a new record in atomic clock performance, with a systematic uncertainty of just 2.1 × 10⁻¹⁸ for their ⁸⁷Sr atomic clock.

Endowing composite materials with spatially discrete mechanical behaviours is possible by varying the internal concentration and arrangement of particles. Here, the authors demonstrate a 3D magnetic printing technique which enables the fabrication of materials with intricate internal designs.

Diving deep into material insights, the authors introduce the ‘Decoupled Optical Force Nanoscopy’. This innovation uncovers the physical origins of light induced forces and captures dynamic thermal details with unparalleled nanometer precision.

The coupling of magnetism and ferroelectricity is of relevance for applications such as sensing, but occurs only rarely in bulk materials. The large magnetically induced ferroelectric polarization observed here in CaMn₇O₁₂establishes a new approach to achieve a strong magnetoelectric coupling.

A Fourier-transform waveguide spectrometer is demonstrated by using HgTe-quantum-dot-based photoconductors with a spectral response up to a wavelength of 2 μm. The spectral resolution is 50 cm^–1. The total active spectrometer volume is below 100 μm × 100 μm × 100 μm.

Graphene nanoribbons with zigzag edges are key candidates for spintronic applications due to their tunable bandgaps and spin-polarized edge states. Now it has been shown that hybrid ribbons embedded with metalloporphyrins enable strong electronic and magnetic coupling between distant metal centres, positioning such hybrids as promising materials for quantum devices.

Spin–photon interfaces provide a connection between quantum information stored in atomic or electronic spins and optical communications networks. A quantum photon emitter with long-lived, controllable coherent spin has now been demonstrated.

URAT1 is the target for gout drugs that block urate reuptake in the kidneys, however current treatments have limitations. Here, authors show how urate-lowering drugs inhibit URAT1, facilitating antigout drug development.

Conventional spectroscopic techniques are not sufficiently selective to follow the dynamics of trapped carriers in working perovskite solar cells. Here, authors use infrared optical activation spectroscopy to observe real time evolution of trapped carriers and compare the behaviour of trapped holes.

During speech, neurons in the subthalamic nucleus transiently couple with cortex oscillations. Speech sound errors occur when this coupling is delayed. These findings enhance understanding of information processing in human brain during speech.

A self-referenced optical frequency comb with digital electronics is used for real-time attosecond control of the comb’s pulse train, and can be used in quantum-limited sensing.

Spectral modulation of a broadband pump beam allows sensitive and specific molecular imaging based on stimulated Raman scattering. Measurements of cholesterol, protein, and stearic and oleic acid are reported.

Tuning the structure in the atomic scale enables manipulation of the quantum state in a molecular based system. Here, Hiraokaet al. tune the Kondo coupling between molecular spins and the Au electrode by controlling the position of Fe²⁺ions in the molecular cage with a tip.

In general, heating increases disorder and leads to the loss of magnetism in condensed matter. Here, the authors demonstrate that a normal metal can be magnetized by applying a temperature gradient during non-uniform heating when attached to a magnetic insulator.

Although optomechanics enables precision metrology, measurements beyond mechanical properties often require hybrid devices. Here, Kim et al. demonstrate that a ferromagnetic needle integrated with a torsional resonator can determine the magnetic properties and amplify or cool the resonator motion.

Supercontinuum-enhanced terahertz spectroscopy breaks the trade-off between distortion and resolution in chirped single-shot measurements, enabling high-resolution and ultrafast measurements of refractive and absorptive properties of dynamic media.

Reducing rotational dephasing is a major challenge in ultracold molecules. Here, the authors demonstrate coherent control of three rotational states in ultracold molecules trapped in magic-wavelength optical tweezers, opening prospects towards quantum applications with higher-dimensional systems.

In eukaryotes, DNA replication depends on loading the ring-shaped helicase, Mcm2–7 onto double-stranded DNA and subsequent activation by GINS–Cdc45. Using single-particle EM reconstructions, the Mcm2–7 forms ring hexamers that are open between Mcm2 and Mcm5. When present, GINS and Cdc45 both seal off this gap. In the presence of a non-hydrolyzable ATP analog, two pores are formed. In this way, the complex could promote duplex opening and then segregate the two strands by partitioning them into the two pores.

Magnetometers based on organic magnetoresistance are limited by narrow sensitivity ranges, degradation and temperature fluctuations. Bakeret al. demonstrate a magnetic resonance-based organic thin film magnetometer, which overcomes these drawbacks by exploiting the metrological nature of magnetic resonance.

Recently, the quantum anomalous Hall effect has been successfully achieved in the intrinsic magnetic topological insulator MnBi₂Te₄, but zero-field quantization has proved difficult to achieve due to poor sample quality. Here, the authors report zero-field quantization and chiral edge states in five-septuple-layer MnBi₂Te₄.

Free, or solvated, electrons in a solution are known to form at the interface between a liquid and a gas. Here, the authors use absorption spectroscopy in a total internal reflection geometry to probe solvated electrons generated at a plasma in contact with the surface of an aqueous solution

Interfacial charge transfer states are believed to have an important role in the performance of organic solar cells. Bernardo et al.show that delocalization achieved through local fullerene order is critical to achieving long-range charge separation from these otherwise tightly bound states.

An improved ligand-exchange process allows the realization of solution-deposited films of quantum dots with reduced energetic disorder and, as a result, solar cells with improved open-circuit voltage, charge-carrier transport and stability.

A new p-type small molecule enhances defect passivation and improves interfacial charge transport in perovskite solar cells, enabling devices with a certified power conversion efficiency of 26.72%, 97% of which is maintained after 2,500 h of continuous operation.