Search

Quantum memories usually suffer from a trade-off between efficiency and excess noise. Here, by exploiting the time-reversal approach for improving modes matching, the authors show a warm-atomic-cell-based cavity-enhanced memory with 67% efficiency and noise level close to quantum noise limit.

The semileptonic decay channels of the Λc baryon can give important insights into weak interaction, but decay into a neutron, positron and electron neutrino has not been reported so far, due to difficulties in the final products’ identification. Here, the BESIII Collaboration reports its observation in e+e- collision data, exploiting machine-learning-based identification techniques.

At the Large Hadron Collider, the MoEDAL experiment shows no evidence for magnetic monopoles generated via the Schwinger mechanism at integer Dirac charges below 3, and suggests a lower mass limit of 75 GeV/c².

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

Tailored growth of MOFs is of great interest for a broad range of applications. Here authors present the use of soft nanobrushes to direct the growth of MOF nanoarrays on requisite substrates, which simultaneously allows the loading of auxiliary functional species for advanced catalysis and sensing applications.

The production of the anticancer drug paclitaxel depends on the extraction of the intermediate baccatin III from Taxus species. This Review highlights recent progress in genome-level analysis of paclitaxel and baccatin III biosynthesis based on sequenced Taxus genomes to guide the future discovery of biosynthesis genes.

Conventional propylene epoxidation uses corrosive oxidants, facing separation issues and instability. Here, the authors report an Ag-V catalyst in membrane electrode assembly system for propylene oxide production via direct electro-epoxidation, eliminating oxidants and enabling instant separation.

Zika and chikungunya virus are co-circulating in many regions and currently there is no approved vaccine for either virus. Here, the authors engineer one vaccinia virus based vaccine for both, Zika and chikungunya, and show protection from infection and pathogenesis in mice.

Ultrasound-responsive liposomes integrating thylakoid fragments and encapsulating l-ascorbic acid can restore the antioxidant capacity of renal tubular cells via NAD⁺ biosynthesis and mitochondrial repair in animal models of acute kidney injury.

Here the authors immobilize quaternary ammonium cations on the surface of Cu catalyst to suppress the carbonate precipitation, achieving a Faradaic efficiency of 50% for ethylene product at 200 mA/cm² from CO₂ electroreduction.

Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

Reverse osmosis of seawater is a popular though energy demanding process to produce freshwater. Interfacing reverse osmosis membranes with solar steam generation shows potential for a more efficient desalination process.

A ketogenic diet can reduce calorie absorption and protect against obesity by inducing changes to the gut microbiota and the bile acid pool.

This study aims to address a critical knowledge gap concerning the unique microstructure in 3D-printed metals by quantitatively characterizing the phase and dislocation density during the printing process using operando synchrotron X-ray diffraction.

In a randomized phase 2 trial comparing anti-PD-1 plus anti-VEGF plus an HDAC inhibitor versus anti-PD-1 plus an HDAC inhibitor in patients with MSS/pMMR colorectal cancer, the triplet combination led to significantly better 18-week progression-free survival.

Catalytic syngas conversion is an essential part of sustainable chemical production but is hindered by the trade-off between conversion activity and product selectivity. Here the authors address this challenge by developing a catalytic shunt strategy.

Here the authors identify TNIP1 as a risk factor for a fatal neurodegenerative disorder and discover specific genetic loci associated with the three main subtypes of this disorder. The findings highlight distinct disease mechanisms, emphasizing the roles of immunity and the notch signaling pathway.

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

A magnetoresistance effect that occurs in a platinum layer deposited on a magnon junction consisting of two insulating magnetic yttrium iron garnet layers separated by an antiferromagnetic nickel oxide spacer layer could be used to create spintronic and magnonic devices that are free from Joule heating.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

Oral administration of the anti-diabetic drug acarbose is shown to enhance the efficacy of cancer anti-PD-1 immunotherapy in female mice by modulating the composition and metabolism of the gut microbiota.

Fluorinated polyacetylene has typically proven to be inaccessible using traditional polymer synthesis, but there is much interest in its predicted properties. Now, a mechanochemical unzipping strategy has succeeded in the synthesis of a gold-coloured, semiconducting fluorinated polyacetylene with improved stability in air compared to polyacetylene.

Using multistate models, the authors examine the effects of loneliness and social isolation on the transition from a healthy state to cardiovascular disease, subsequent depression and death.

Van der Waals heterostructures offer a platform for harnessing the spin-valley degree of freedom for information processing. Here, the authors transfer optically generated spin-valley polarization from one layer to another in a two-dimensional molybdenum diselenide–tungsten diselenide heterostructure.

60Fe and 26Al provide insights about active nucleosynthesis in our galaxy and there is a discrepancy between observed and theoretically predicted ratios. Here, the authors show that this discrepancy is higher than previously found.

Multiple exciton generation has been shown to improve the performance of quantum-dot-based solar cells. Yan et al. now apply it to photoinduced hydrogen production and present a system using PbS quantum-dot photoelectrodes that yields an external quantum efficiency of over 100%.

Donor exciton delocalization and its impact on photovoltaic performance of organic solar cells remains less explored. Here, the authors found that delocalized excitons are formed in aggregates of the donor polymer D18, and that these delocalized excitons mediate charge generation in solar cells.

In micro-nano polymeric composites, the modulation of phosphorescent emission performance through macroscopic electrostatic interactions not only significantly enhances emission intensity but also effectively extends the phosphorescence lifetime.

Analyses of genome and exome sequencing data identify rare coding and structural variants associated with atrial fibrillation and highlight genetic links between atrial fibrillation and cardiomyopathies.

Hepatic stellate cells regulate hepatocyte functions via R-spondin 3.

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s  = 13 TeV and an integrated luminosity of 140 fb⁻¹.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

The interactions between tertiary lymphoid structures (TLS) and tumor cell aggregates remain to be investigated. Here, single-cell and spatial transcriptomics reveal the cellular composition, formation, and function of TLS during tumour progression and immunotherapy response in nasopharyngeal carcinoma.

Cai et al. report gate-injection-mode floating-gate memories based on MoS2 channel. The coplanar device design and bi-pulse state programming enable 8-bit conductance states at 3 V. Image convolutions are implemented and 38,592 convolutional kernel parameters are projected on a 9 × 2 device array.

Using data from a single time point, passenger-approximated clonal expansion rate (PACER) estimates the fitness of common driver mutations that lead to clonal haematopoiesis and identifies TCL1A activation as a mediator of clonal expansion.

Generic synthesis of metal-N4 moieties is interesting but challenging. Here the authors report an interfacial-fixing strategy to prepare neighboring metal-N4 sites, such as Fe2-N6, for oxygen reduction reaction.

While chemotherapy may initially be effective in patient with nasopharyngeal carcinoma (NPC), resistance often develops. Here, the authors identify PJA1 as a driver of resistance to docetaxel via inhibition of GSDME-mediated proptosis and target this using a PJA1 inhibitor to restore sensitivity in preclinical models of NPC.

High-fidelity deterministic quantum state transfer and multi-qubit entanglement are demonstrated in a quantum network comprising two superconducting quantum nodes one metre apart, with each node including three interconnected qubits.