Although the capacity for tissue regeneration of planarians is exceptional, planarians with more limited regenerative capacities are known; here knocking down components of the Wnt signalling pathway rescues head regeneration in the regeneration-impaired planarian Dendrocoelum lacteum, revealing that manipulating a single signalling pathway can reverse the evolutionary loss of regenerative potential.
- S.-Y. Liu
- C. Selck
- J. C. Rink
