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ATPγS, a slowly-hydrolysed ATP analogue, causes kinesin to take extra backsteps under load. Here, the authors examine single-molecule mechanics and propose a state in which forward steps and coupled ATP hydrolysis are turned off, but unsteered steps are allowed.

ROS1, a known oncogene, is an orphan receptor tyrosine kinase whose activation mechanism has remained elusive. Cryo-EM structures of ROS1 reveal how ligand activates the receptor and how monoclonal antibodies inhibit ROS1 signaling.

How the brain maintains object representations during grasping, when complex sensory input rapidly changes, remains poorly understood. Here the authors show that object-identity signals shift and strengthen across sensorimotor cortex as reaching transitions to grasping.

Amundsen Sea records show warm Circumpolar Deep Water drove major West Antarctic Ice Sheet retreat from 18,000–10,000 years ago. Subsequent cooling stabilized the grounding line, indicating ocean heat—not atmospheric warming—controlled long-term WAIS change.

The long-term natural history of long-COVID is not well understood. In this population-based cohort study from Scotland, the authors describe symptom prevalence and health-related quality of life up to 18 months after a positive SARS-CoV-2 test and compare with matched test-negative controls.

Spectroscopic observations of the ultra-hot Jupiter WASP-189b reveal both volatile (H₂O, CO, OH) and refractory (Fe, Mg, Si) gas in its atmosphere. Here, the authors show that the abundance ratio of refractory species reflects that of the host star.

Lactone monomers for recyclable polyesters are conventionally synthesized via endergonic, non-oxidative dehydrocyclization of fossil-derived diols in the vapor phase over precious-metal catalysts at elevated temperatures. Here, the authors demonstrate a low-temperature, solvent-free, oxidative route to lactones from bio-derivable liquid diols using earth-abundant calcium-copper mixed-metal oxide catalysts.

The study of highly active electrodes in organic electrosynthesis remains an under-investigated component of the subfield. This work introduces a bottom-up route to prepare chitin-derived composite carbon aerogel electrodes (CCAEs), which can be directly used as electrodes in organic electrosynthesis systems.

Here the authors report a kilowatt-scale, alkali-cation-free CO₂ electrolysis system using high-diffusion-flux gas diffusion electrodes, achieving over 1000 h of stability for efficient CO or C₂H₂ production at industrially relevant current densities.

Tiny protein crystals often evade X-ray methods. Here, authors solved the seed protein crambin at 0.85 Å by ab initio MicroED from 58 self-formed nanocrystals on standard 200 kV hardware, resolving hydrogen atoms using anisotropy-aware merging.

Efficacy of transdermal testosterone gel in treatment for female infertility remained unknown. Authors conducted randomized clinical trial to show transdermal testosterone did not improve clinical pregnancy rates.

Medicine anticounterfeiting represents a significant challenge, with methods for detection of this limited. Here, the authors report the development of edible phosphorescent supramolecules suitable for use as phosphorescent inks for in-medicine anticounterfeiting.

The role of interfacial water structures in regulating the acidic oxygen evolution performance of cobalt spinel oxides has long been overlooked. Here, the authors report that chromium doping can enhance the activity and stability of cobalt spinel oxide through promoting interfacial water dissociation.

Treating tuberculosis remains a challenge due to the complex microenvironment. Here the authors identify immunosuppression in granulomas and develop a targeted sono-immunotherapy strategy to selectively kill M.tb in macrophages, release antigens, and trigger immunity to treat and prevent recurrence of tuberculosis.

Post-acute infection syndromes often have heterogeneous symptoms that are difficult to interpret. Here, the authors develop a latent trajectory analysis framework designed to categorise complex relationships in longitudinal data into distinct disease phenotypes and analyse transitions between them.

How the brain supports speaking and listening during conversation of its natural form remains poorly understood. Here, by combining intracranial EEG recordings with Natural Language Processing, the authors show broadly distributed frontotemporal neural signals that encode context-dependent linguistic information during both speaking and listening..

LARP6 is an EMT-associated RNA-binding protein with diverse RNA targets. Here, the authors show that the N-terminal disordered region of LARP6 promotes RNA-binding selectivity by modulating the adjacent La-module and forming auxiliary contacts with RNA.

Nicotinamide adenine dinucleotide (NAD) biosynthetic enzymes have been reported to be oncogenic. Here, the authors show that NAPRT, a key enzyme in the deamidated NAD biosynthesis pathway, functions as a suppressor of colon inflammation and tumorigenesis by maintaining DNA repair capability.

Neoantigen-based adoptive T cell therapies represent a personalized approach for cancer immunotherapy. Here the authors describe NEO-STIM, an ex vivo T cell induction platform to STIMulate peripheral blood T cells to generate responses against tumor NEOantigens.

Human and swine H3N2 influenza A viruses were shown to use MHC class II as a sialic acid–independent, host-specific entry receptor, potentially expanding viral cell tropism. Furthermore, affinity for swine MHCII was higher in viruses adapted to pigs, suggesting a role in host range.

Neuropathic pain is commonly treated with opioids due to limited alternatives. Here, authors determine cryo-EM structures of the neuronal glycine transporter GlyT2 and develop a reversible inhibitor that provides analgesia in vivo without side effects.

Precise and efficient CRISPR genome editing requires specialized delivery systems. Here, the authors develop Coomassie lipidoids that deliver purified adenine base editors into retinal tissues, making it possible to achieve robust genome editing with a defined, non-viral nanomedicine.

In this study, the authors develop a stoichiometric-thermodynamic model linking seismic decarbonation to Mw 5.9–6.5 earthquakes. They demonstrate that seismic CO₂ pressurization can sustain dynamic slip and enhance the destructive potential of earthquakes.

Post-transcriptional regulation of mRNA translation was explored using Ribo-STAMP and single-cell RNA sequencing to reveal cell-type-specific and isoform-specific translation patterns across hippocampal neuronal and non-neuronal cell types, highlighting functional differences between CA1 and CA3.

A genome assembly method called hifiasm (ONT) allows the assembly of chromosomes from telomere to telomere without the need for ultra-long reads, and outperforms conventional methods on most evaluation metrics.

In this study, the authors designed potent Enterovirus D68 capsid inhibitors that block viral binding and show that the lead compounds reduce virus levels, prevent paralysis and improve survival in EV-D68-challenged mice, even when treatment starts days after infection.

Top-down projections from the orbitofrontal cortex carry predictive signals that grow with sound experience and suppress the auditory cortex via inhibitory circuits, revealing a predictive mechanism for sensory habituation.

Neuromorphic photonic systems can incur significant energy for moving and converting data between digital and analog domains. This work shows that integrating analog memory into these processors can save 26 × power over conventional digital-to-analog architectures while keeping  > 90% inference accuracy.

This case report presents a multi-omics case analysis of intravenous phage-antibiotic co-therapy in a patient with cystic fibrosis during an acute-on-chronic pulmonary exacerbation caused by multidrug-resistant Pseudomonas aeruginosa.

Nanomaterials with chiral photoluminescence are promising candidates for advanced optical technologies. Here, the authors use mechsanochemical processing to tune the emission of circularly polarized light and enhance the nonlinear optical response in indium-based halides.

Diamond anvils are widely used in high-pressure research to investigate matter under extreme conditions. Here, broadband spectroscopy is used to measure pressure-driven opacity of diamond anvils to 520 GPa, revealing bandgap narrowing and optical behavior that redefines the limits of high-pressure spectroscopy.

Critical life-history traits, like growth and body size, can influence species’ survival. Using more than 7500 observations, this study suggests that the growth performance of marine fish has declined by 9% over the past century as a result of commercial size-based harvesting.

Large snowpack temperature gradients drive vertical mass transfer on Arctic sea ice, forming sea-ice sourced snow. Stratigraphic and stable water isotope investigations show this contribution may reach 39–63 mm snow depth equivalent.

This paper presents an active pixel power control (APPC) to minimize crosstalk in all-optical neural interrogation. Tested in vivo, APPC suppresses optogenetic artifacts while preserving Ca2+ imaging quality, enabling precise neural circuit analysis.

Lithium metal offers high specific capacity but suffers from dendrite growth and poor cycling stability. Here, authors develop a 3D Li-Zn-Li3N/CNT composite combining ductile Li-Zn alloy and a mechanically robust Li3N-CNTs network, enabling thin, durable electrodes with uniform lithium deposition, demonstrating a pouch-cell with a specific energy of 553 Wh kg-1.

Soft and conducting organic materials are promising for electronic devices, though their nanostructures are not fully understood, due to the lack of high resolution real spacing imaging of these complex systems. Here the authors use cryogenic transmission electron microscopy methods to investigate the morphology of PEDOT:PSS in the presence of additives and upon hydration.

Recent work has revealed quantum coherent phase slips and current quantization in superconductors, phenomena dual to Cooper pair tunneling and voltage quantization. By combining the two effects, the authors demonstrate a Bloch transistor, a device that delivers quantized current and features a unique phase-locking mechanism.

Lithium metal batteries face challenges of unstable interfaces and slow ion transport. Here, authors report a hydrogen-bonded domain electrolyte based on addition of 2-cyano-N-methylacetamidethat as cosolvent which enhances ion transport and interface stability, enabling long cycling high voltage (up to 4.7 V) Li | |LiNi0.8Co0.1Mn0.1O2 batteries with high specific energy of 418.2 Wh kg⁻¹.

Surface-selective In³⁺ substitution in BiVO₄ suppresses hole polarons by weakening electron-phonon coupling. This strategy releases trapped carriers, significantly enhancing solar water splitting efficiency for sustainable fuel production.

Schober and colleagues show that effector CD8⁺ T cells undergo metabolic shutdown, CD8⁺ central memory T cells are the most metabolically active, and naive-like memory T cells are quiescent during the acute phase of the immune response and represent the dominant population of memory CD8⁺ T cells after yellow fever vaccination in humans.

Neural mechanisms underlying active avoidance are not fully understood. Here authors show that avoidance actions are positively reinforced by learned safety signals. With training, control shifts from goal-directed to habitual behavior via distinct dorsal striatal circuits, like reward-based learning.

In this work, authors present an automated, high-throughput platform that utilizes robotics and computer vision to enable creation of a therapeutic phage cocktail, LBP-EC01, effective against over 96% of tested Escherichia coli isolates from urinary tract infections.

Most GWAS have focused on common variants or rare protein coding variants. Here, the authors interrogate the contribution of rare non-coding variants for anthropometric traits, identifying new genes associated with increased BMI and height.

Expression quantitative trait loci (eQTL) analysis in patients with inflammatory bowel disease identify potential target genes for IBD GWAS loci not readily detected in individuals without disease highlighting the importance disease-focused studies.

Bioresorbable piezoelectric materials are key for bioelectronic–tissue integration but remain challenging to realize. Here, the authors develop flexible Rochelle salt/PLLA nanofibers that enable effective nerve regeneration and wireless monitoring of intestinal motility.

Yin et al. report linear conjugated polymer donors with chlorinated backbone for modulating polymer aggregation and surface tension, and optimised compatibility with norfullerene acceptors. By using binary blends, a 20.42% efficiency is achieved for organic solar cells.

The chemistry of phosphaalumenes featuring multiple bonds between phosphorus and aluminum remains largely unexplored. Here the authors report the synthesis of a phosphaalumene and characterize its activation of small molecules.

HIV-1 integrase forms an RNA-binding module on the luminal side of the mature capsid lattice.