Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–12 of 12 results
Advanced filters: Author: Raffaella Di Micco Clear advanced filters

  • Analyses of single-cell transcriptomic data from patients with VEXAS syndrome combined with xenotransplantation experiments in a mouse model of the disease provide insights on the mechanisms of clonal dominance of mutated cells leading to bone marrow failure

    • Raffaella Molteni
    • Martina Fiumara
    • Samuele Ferrari
    ResearchOpen Access
    Nature Medicine
    Volume: 31, P: 1911-1924

  • Here the authors develop an assay capable of selecting Sec61 inhibitors by exploiting the inactivation of firefly luciferase, once translocated into the endoplasmic reticulum (ER), and the possibility of diverting and “re-lighting” luciferase into the cytosol by a Sec61 inhibitor.

    • Fulvia Vitale
    • Gianluca Scerra
    • Massimo D’Agostino
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • BRAF-MAPK activating mutations are reported in histiocytoses—hematological neoplasms with widespread pro-inflammatory myeloid cells. Here, the authors show that an activating mutant BRAF in haematopoietic stem and progenitor cells causes an oncogene-induced senescence response leading to myeloid restricted haematopoiesis, inflammation and histiocytosis.

    • Riccardo Biavasco
    • Emanuele Lettera
    • Eugenio Montini
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • Arginine methylation is crucial for tumor maintenance. PRMT9 levels are elevated in acute myeloid leukemia, and its inhibition eradicates leukemia by diminishing arginine methylation of proteins involved in DNA damage response and RNA translation. This activates the cGAS–STING pathway, which triggers immune responses directed against leukemia. Epigenetic targeting of DNA-damage-response mechanisms may bolster anti-tumor immunity.

    • Antonella Santoro
    • Raffaella Di Micco
    News & Views
    Nature Cancer
    Volume: 5, P: 539-541

  • Relapse within acute myeloid leukaemia may be driven by the presence of leukaemia stem cells. Here, the authors use single cell RNA-seq seq to characterise leukemia stem cells, and show miR-126 as a potential marker of resistance.

    • Matteo Maria Naldini
    • Gabriele Casirati
    • Bernhard Gentner
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-20

  • Chromatin conformation and chromatin modifications affect DNA damage response signalling and hence the associated cellular outcomes of this response. This Opinion article discusses the implications of chromatin alterations in cancer cells on DNA damage responses.

    • Gabriele Sulli
    • Raffaella Di Micco
    • Fabrizio d'Adda di Fagagna
    Reviews
    Nature Reviews Cancer
    Volume: 12, P: 709-720

  • Cellular senescence is characterized by a permanent proliferation arrest and the establishment of a senescence-associated secretory phenotype. This Review discusses the mechanisms of cellular senescence and induction of a senescence-associated secretory phenotype, recent insights into how senescence contributes to ageing, and the potential of senolytic and senomorphic therapies in ageing and associated diseases.

    • Raffaella Di Micco
    • Valery Krizhanovsky
    • Fabrizio d’Adda di Fagagna
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 22, P: 75-95

  • Different mechanisms have been implicated in the induction of senescence. Two of these mechanisms, the DNA damage response, which induces a replicative checkpoint, and the formation of heterochromatic foci, which leads to transcriptional repression, are found to act together in oncogene-expressing cells.

    • Raffaella Di Micco
    • Gabriele Sulli
    • Fabrizio d'Adda di Fagagna
    Research
    Nature Cell Biology
    Volume: 13, P: 292-302

  • Recent studies suggest that neutrophils can exhibit substantial function diversity. Here, Ostuni and colleagues perform immunophenotyping and transcriptome analysis to characterize the heterogeneity of human neutrophils, both under steady state and upon stress-induced conditions.

    • Elisa Montaldo
    • Eleonora Lusito
    • Renato Ostuni
    Research
    Nature Immunology
    Volume: 23, P: 1470-1483

  • Cachexia is a metabolic syndrome leading to muscle and adipose tissue loss in majority of cancer patients. Here the authors show that, in a mouse model, BET inhibitor JQ1 counteracts muscle and adipose tissue wasting tempering cachexia and prolonging survival through a mechanism unrelated to tumour growth.

    • Marco Segatto
    • Raffaella Fittipaldi
    • Giuseppina Caretti
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16