Nature Search

Comprehensive RAD51C ovarian cancer variant analysis uncouples homologous recombination and replicative functions

The tumor suppressor RAD51C is mutated in ovarian cancers. Through variant analysis the authors identify a mutation cluster in the RAD51C Walker B region important for the repair of DNA double-strand breaks and replicative damage. By identifying Walker B separation-of-function alleles, they show that these activities can be uncoupled.

Hayley L. Rein
Yashpal Rawal
Kara A. Bernstein
ResearchOpen Access16 Jul 2025
Nature Communications

Volume: 16, P: 1-13
A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium

The Sequencing Quality Control (SEQC) consortium shows that junction discovery and differential gene expression profiling with RNA-seq can be robust but transcript-level and absolute measurements remain challenging.

Zhenqiang Su
Paweł P Łabaj
Leming Shi
Research24 Aug 2014
Nature Biotechnology

Volume: 32, P: 903-914
Amyloid-associated increases in soluble tau relate to tau aggregation rates and cognitive decline in early Alzheimer’s disease

The interplay between amyloid and tau pathology in Alzheimer’s disease is still not well understood. Here, the authors show that amyloid-related increased in soluble p-tau is related to subsequent accumulation of tau aggregates and cognitive decline in early stage of the disease.

Alexa Pichet Binette
Nicolai Franzmeier
Oskar Hansson
ResearchOpen Access04 Nov 2022
Nature Communications

Volume: 13, P: 1-16
Dissociation of tau pathology and neuronal hypometabolism within the ATN framework of Alzheimer’s disease

In Alzheimer’s disease (AD) tau and neurodegeneration have complex regional relationships. Here, the authors show neuronal hypometabolism discordant with tau burden defines functional resilience or susceptibility to Alzheimer’s pathology via limbic/cortical axes. Susceptible groups have faster cognitive decline and evidence of non-Alzheimer’s pathologies.

Michael Tran Duong
Sandhitsu R. Das
Ilya M. Nasrallah
ResearchOpen Access21 Mar 2022
Nature Communications

Volume: 13, P: 1-15
A deep learning framework identifies dimensional representations of Alzheimer’s Disease from brain structure

Alzheimer’s disease is heterogeneous in its neuroimaging and clinical phenotypes. Here the authors present a semi-supervised deep learning method, Smile-GAN, to show four neurodegenerative patterns and two progression pathways providing prognostic and clinical information.

Zhijian Yang
Ilya M. Nasrallah
Balebail Ashok Raj
ResearchOpen Access03 Dec 2021
Nature Communications

Volume: 12, P: 1-15
Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease

Alzheimer’s disease has been associated with increased structural brain aging. Here the authors describe a model that predicts brain aging from resting state functional connectivity data, and demonstrate this is accelerated in individuals with pre-clinical familial Alzheimer’s disease.

Julie Gonneaud
Alex T. Baria
Etienne Vachon-Presseau
ResearchOpen Access09 Sept 2021
Nature Communications

Volume: 12, P: 1-17
Four distinct trajectories of tau deposition identified in Alzheimer’s disease

Systematic characterization of longitudinal tau variability in human Alzheimer’s disease using an unbiased subtyping algorithm reveals four trajectories of tau deposition with distinct clinical features.

Jacob W. Vogel
Alexandra L. Young
Oskar Hansson
Research29 Apr 2021
Nature Medicine

Volume: 27, P: 871-881
KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer’s disease

The KL-VS haplotype of the Klotho gene has been associated with reduced risk of Alzheimer’s disease and dementia. Here the authors show an association between the KL-VS haplotype and amyloid-dependent tau accumulation using PET data.

Julia Neitzel
Nicolai Franzmeier
Michael Ewers
ResearchOpen Access22 Jun 2021
Nature Communications

Volume: 12, P: 1-12
Functional brain architecture is associated with the rate of tau accumulation in Alzheimer’s disease

Tau accumulation is associated with disease progression in Alzheimer’s disease. Here the authors use resting state fMRI and tau-PET to demonstrate that baseline connectivity in Alzheimer's disease is associated with tau spreading.

Nicolai Franzmeier
Julia Neitzel
Balebail Ashok Raj
ResearchOpen Access17 Jan 2020
Nature Communications

Volume: 11, P: 1-17
Human lifespan changes in the brain’s functional connectome

Sun et al. report human lifespan changes in the brain’s functional connectome in 33,250 individuals, which highlights critical growth milestones and distinct maturation patterns and offers a normative reference for development, aging and diseases.

Lianglong Sun
Tengda Zhao
Yong He
Research03 Apr 2025
Nature Neuroscience

Volume: 28, P: 891-901
Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease

The tau protein is theorized to spread transneuronally in Alzheimers disease, though this theory remains unproven in humans. Our simulations of epidemic-like protein spreading across human brain networks support this theory, and suggest the spreading dynamics are modified by β-amyloid

Jacob W. Vogel
Yasser Iturria-Medina
Per Wollmer
ResearchOpen Access26 May 2020
Nature Communications

Volume: 11, P: 1-15
Charcot–Bouchard aneurysms revisited: clinicopathologic correlations

Shino Magaki
Zesheng Chen
Harry V. Vinters
ResearchOpen Access14 Jun 2021
Modern Pathology

Volume: 34, P: 2109-2121
Liver transplantation: past, present and future

Liver transplantation has progressed from an experimental procedure to routine operation since the first human liver transplantation in 1963. This Timeline article revisits the important milestones in the development of liver transplantation, discussing how the procedure has evolved over time and what challenges are still to overcome.

Ali Zarrinpar
Ronald W. Busuttil
Reviews11 Jun 2013
Nature Reviews Gastroenterology & Hepatology

Volume: 10, P: 434-440
Recreational water exposure and waterborne infections in a prospective salivary antibody study at a Lake Michigan beach

Andrey I. Egorov
Reagan Converse
Timothy J. Wade
ResearchOpen Access15 Oct 2021
Scientific Reports

Volume: 11, P: 1-10
Author Correction: Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease

Jacob W. Vogel
Yasser Iturria-Medina
Per Wollmer
Amendments and CorrectionsOpen Access05 Aug 2021
Nature Communications

Volume: 12, P: 1
Multiomics analysis to explore blood metabolite biomarkers in an Alzheimer’s Disease Neuroimaging Initiative cohort

Takaki Oka
Yuki Matsuzawa
Balebail Ashok Raj
ResearchOpen Access02 Apr 2024
Scientific Reports

Volume: 14, P: 1-14
Characteristic patterns of inter- and intra-hemispheric metabolic connectivity in patients with stable and progressive mild cognitive impairment and Alzheimer’s disease

Sheng-Yao Huang
Jung-Lung Hsu
Balebail Ashok Raj
ResearchOpen Access14 Sept 2018
Scientific Reports

Volume: 8, P: 1-11
Robust Identification of Alzheimer’s Disease subtypes based on cortical atrophy patterns

Jong-Yun Park
Han Kyu Na
Balebail Ashok Raj
ResearchOpen Access09 Mar 2017
Scientific Reports

Volume: 7, P: 1-14

Search

Comprehensive RAD51C ovarian cancer variant analysis uncouples homologous recombination and replicative functions

A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium

Amyloid-associated increases in soluble tau relate to tau aggregation rates and cognitive decline in early Alzheimer’s disease

Dissociation of tau pathology and neuronal hypometabolism within the ATN framework of Alzheimer’s disease

A deep learning framework identifies dimensional representations of Alzheimer’s Disease from brain structure

Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease

Four distinct trajectories of tau deposition identified in Alzheimer’s disease

KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer’s disease

Functional brain architecture is associated with the rate of tau accumulation in Alzheimer’s disease

Human lifespan changes in the brain’s functional connectome

Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease

Charcot–Bouchard aneurysms revisited: clinicopathologic correlations

Liver transplantation: past, present and future

Recreational water exposure and waterborne infections in a prospective salivary antibody study at a Lake Michigan beach

Author Correction: Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease

Multiomics analysis to explore blood metabolite biomarkers in an Alzheimer’s Disease Neuroimaging Initiative cohort

Characteristic patterns of inter- and intra-hemispheric metabolic connectivity in patients with stable and progressive mild cognitive impairment and Alzheimer’s disease

Robust Identification of Alzheimer’s Disease subtypes based on cortical atrophy patterns

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