Nature Search

Genetic modifiers of APOE-ε4-associated cognitive decline

The APOE-ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease, but it is not deterministic. Here, the authors show that common genetic variation changes how APOE-ε4 influences cognition.

Alex G. Contreras
Skylar Walters
Timothy J. Hohman
ResearchOpen Access20 Feb 2026
Nature Communications

P: 1-17
cellSTAAR: incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of noncoding regions

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

Eric Van Buren
Yi Zhang
Xihong Lin
Research31 Dec 2025
Nature Methods

Volume: 23, P: 338-349
Evaluation of mango (Mangifera indica L.) germplasm for phenotypic diversity and breeding potential in Pakistan

Wajiha Zaka Ansari
Hannan Mukhtar
Robert J. Henry
ResearchOpen Access05 Jan 2026
Scientific Reports

Volume: 16, P: 1-25
Mapping the genetic landscape across 14 psychiatric disorders

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

Andrew D. Grotzinger
Josefin Werme
Jordan W. Smoller
ResearchOpen Access10 Dec 2025
Nature

Volume: 649, P: 406-415
SARS-CoV-2 occurrence in cervids in the United States and US territories

Sarah N. Bevins
Richard B. Chipman
Susan A. Shriner
ResearchOpen Access15 Jan 2026
Scientific Reports

Volume: 16, P: 1-8
PULMONARY May 17, 1973, 2:00 P.M. Continental Ballroom 6

Robert B Mellins
Research01 Apr 1973
Pediatric Research

Volume: 7, P: 59-168
Antarctic glaciers export carbon-stabilised iron(II)-rich particles to the surface Southern Ocean

Authors show that Antarctic glaciers deliver high particle loads to the ocean, rich in iron that is potential food for marine algae. Microscopy techniques reveal this iron interacts with carbon. Ocean tracers show this glacial iron reaches far offshore.

Rhiannon L. Jones
Jon R. Hawkings
Amber L. Annett
ResearchOpen Access30 May 2025
Nature Communications

Volume: 16, P: 1-10
Retreat of the East Antarctic ice sheet during the last glacial termination

The East Antarctic ice sheet retreated at the end of the last glacial period. Terrestrial and marine data suggest that the retreat began 14,000 years ago, indicating that the East Antarctic ice sheet probably did not contribute to meltwater pulse 1a 14,700 years ago.

Andrew Mackintosh
Nicholas Golledge
Caroline Lavoie
Research16 Jan 2011
Nature Geoscience

Volume: 4, P: 195-202
Nitrogenase

Robert R. Eady
John R. Postgate
Research28 Jun 1974
Nature

Volume: 249, P: 805-810
[Letters to Editor]

ROBERT W. LAWSON
Research18 Dec 1948
Nature

Volume: 162, P: 970
Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database

Here the authors provide an explanation for 95% of examined predicted loss of function variants found in disease-associated haploinsufficient genes in the Genome Aggregation Database (gnomAD), underscoring the power of the presented analysis to minimize false assignments of disease risk.

Sanna Gudmundsson
Moriel Singer-Berk
Anne O’Donnell-Luria
ResearchOpen Access31 Oct 2025
Nature Communications

Volume: 16, P: 1-14
Evidence for improved DNA repair in the long-lived bowhead whale

Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein.

Denis Firsanov
Max Zacher
Vera Gorbunova
ResearchOpen Access29 Oct 2025
Nature

Volume: 648, P: 717-725
Reduction of Perinatal Hypoxic-Ischemic Brain Damage with Allopurinol

Charles Palmer
Robert C Vannucci
Javad Towfighi
Research01 Apr 1990
Pediatric Research

Volume: 27, P: 332-336
Large-scale ice-shelf calving events follow prolonged amplifications in flexure

The loss of sea ice enhances swell-induced flexural stress in Antarctic ice shelves before large-scale calving events, according to satellite observations and swell-induced flexural stress modelling.

Nathan J. Teder
Luke G. Bennetts
Alexander D. Fraser
ResearchOpen Access01 Jul 2025
Nature Geoscience

Volume: 18, P: 599-606
Sense and sensibility

Could literature teach us how to release scientific writing from its straitjacket?

Robert Simmons
Research01 May 2001
Nature

Volume: 411, P: 243
Peripheral expansion of pre-existing mature T cells is an important means of CD4⁺ T-cell regeneration HIV-infected adults

Robert E. Walker
Charles S. Carter
H. Clifford Lane
Research01 Jul 1998
Nature Medicine

Volume: 4, P: 852-856
Hæmolytic Effects of Steroids

ROBERT H. PALMER
Research14 Mar 1964
Nature

Volume: 201, P: 1134-1135
Isolation of a Highly Purified Encephalitogenic Protein from Bovine Cord

ROBERT F. KIBLER
RICHARD H. FOX
RAYMOND SHAPIRA
Research26 Dec 1964
Nature

Volume: 204, P: 1273-1275
The virus of Japanese adult T-cell leukaemia is a member of the human T-cell leukaemia virus group

M. Popovic
M. S. Reitz Jr
R. C. Gallo
Research04 Nov 1982
Nature

Volume: 300, P: 63-66
Conveying tactile object characteristics through customized intracortical microstimulation of the human somatosensory cortex

In this study, three individuals with tetraplegia designed vivid, reliable and object-appropriate sensations with a variety of tactile characteristics using self-selected stimulus parameters that stimulated their somatosensory cortex upon digital object contact

Ceci Verbaarschot
Vahagn Karapetyan
Robert A. Gaunt
ResearchOpen Access01 May 2025
Nature Communications

Volume: 16, P: 1-17
The covalent and tertiary structure of bovine liver rhodanese

Jan H. Ploegman
Gé Drent
John Russell
Research11 May 1978
Nature

Volume: 273, P: 124-129
Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action

Robert C. Frederich
Andreas Hamann
Jeffrey S. Flier
Research01 Dec 1995
Nature Medicine

Volume: 1, P: 1311-1314
Implications of the Far-Infrared Background Measurements

ROBERT V. WAGONER
Research01 Nov 1969
Nature

Volume: 224, P: 481-484
Control of Gene Transcription in T-even Bacteriophages: Alterations in RNA Polymerase accompanying Phage Infection

ROBERT J. CROUCH
BENJAMIN D. HALL
GORDON HAGER
Research02 Aug 1969
Nature

Volume: 223, P: 476-479
The DNA-binding domain of HIV-1 integrase has an SH3-like fold

Astrid P.A.M. Eijkelenboom
Ramon A. Puras Lutzke
Karl Hård
Research01 Sept 1995
Nature Structural Biology

Volume: 2, P: 807-810
An explanation for the protective effect of the MHC class II I–E molecule in murine diabetes

Eva-Pia Reich
Robert S. Sherwin
Charles A. Janeway Jr
Research28 Sept 1989
Nature

Volume: 341, P: 326-328
Harnessing free energy calculations for kinome-wide selectivity in drug discovery campaigns with a Wee1 case study

Free energy calculations are an essential tool to identify targets for individual proteins. Here, authors describe free energy perturbation (FEP+) calculations to optimise on target and off-target potencies for the discovery of potent Wee1 inhibitors with kinome-wide selectivity.

Jennifer Lynn Knight
Anthony J. Clark
Aleksey I. Gerasyuto
ResearchOpen Access26 Aug 2025
Nature Communications

Volume: 16, P: 1-16
Ingrowing toenails and tetraplegia

David Jaffray
W El Masri
Research01 Jun 1985
Spinal Cord

Volume: 23, P: 176-181
The Buoyancy of Whales

ROBERT W. GRAY
Research05 May 1928
Nature

Volume: 121, P: 710-711
Increasing ocean wave energy observed in Earth’s seismic wavefield since the late 20^th century

Ocean waves induce geographically extensive seafloor forces that excite a continuous and globally detectable seismic wavefield. This study infers global near-coastal average wave energy intensification at a rate of 0.27% per year since the late 1980’s, and 0.35% per year since January 2000.

Richard C. Aster
Adam T. Ringler
Thomas A. Lee
ResearchOpen Access01 Nov 2023
Nature Communications

Volume: 14, P: 1-15
Determination of the spin and parity of all-charm tetraquarks

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

A. Hayrapetyan
V. Makarenko
A. Snigirev
ResearchOpen Access03 Dec 2025
Nature

Volume: 648, P: 58-63
Fetal Lung Development in Male and Female Nonhuman Primates

Robert H Perelman
Michael J Engle
Philip M Farrell
Research01 Oct 1986
Pediatric Research

Volume: 20, P: 987-991
Different recombination site specificity of two developmentally regulated genome rearrangements

James W. Golden
Martin E. Mulligan
Robert Haselkorn
Research11 Jun 1987
Nature

Volume: 327, P: 526-529
Light-induced extracellular vesicle and particle adsorption

LEVA is a label-free immobilization method for studying surface-bound extracellular vesicles.

Colin L. Hisey
Xilal Y. Rima
Eduardo Reátegui
ResearchOpen Access18 Nov 2025
Nature Methods

Volume: 22, P: 2609-2621
Genethics and eugenics

The Ethics of Human Gene Therapy by Leroy Walter and Julie Gage Palmer. Oxford University Press, Oxford, 1996, pp.195,(hbk).

Robert Pollack
Books & Arts01 Oct 1996
Nature Biotechnology

Volume: 14, P: 1305
The “Minimum Information about an ENvironmental Sequence” (MIENS) specification

Pelin Yilmaz
Renzo Kottmann
Frank Oliver Glöckner
ResearchOpen Access15 Nov 2010
Nature Precedings

P: 1
A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

Xihao Li
Han Chen
Xihong Lin
Research07 Feb 2025
Nature Computational Science

Volume: 5, P: 125-143
The “Minimum Information about an ENvironmental Sequence” (MIENS) specification

Peter Sterk
Jeffrey Gordon
Doyle Ward
ResearchOpen Access16 Nov 2010
Nature Precedings

P: 1
Rapid retreat of Thwaites Glacier in the pre-satellite era

The Thwaites Glacier grounding zone has experienced sustained pulses of rapid retreat over the past two centuries, according to sea floor observations obtained by an autonomous underwater vehicle.

Alastair G. C. Graham
Anna Wåhlin
Robert D. Larter
ResearchOpen Access05 Sept 2022
Nature Geoscience

Volume: 15, P: 706-713
Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes

Here, the authors perform large trans-ancestry fine-mapping analyses identifying large numbers of association signals and putative target genes for colorectal cancer risk, advancing our understanding of the genetic and biological basis of this cancer.

Zhishan Chen
Xingyi Guo
Wei Zheng
ResearchOpen Access26 Apr 2024
Nature Communications

Volume: 15, P: 1-17
Spatial summation and contrast sensitivity of X and Y cells in the lateral geniculate nucleus of the macaque

Robert Shapley
Ehud Kaplan
Robert Soodak
Research06 Aug 1981
Nature

Volume: 292, P: 543-545
Pathogenic UNC13A variants cause a neurodevelopmental syndrome by impairing synaptic function

Pathogenic variants in UNC13A underlie a novel neurodevelopmental syndrome, with three subtypes defined by distinct genotypes with varying clinical and functional impacts characterized in cellular and animal models.

Reza Asadollahi
Aisha Ahmad
Noa Lipstein
ResearchOpen Access22 Oct 2025
Nature Genetics

Volume: 57, P: 2691-2704
Brain tumors induce widespread disruption of calvarial bone and alteration of skull marrow immune landscape

Glioblastoma—the deadliest form of brain cancer—alters the calvarial bone and its marrow components, pushing it toward producing more myeloid cells and contributing to an immunosuppressive environment.

Abhishek Dubey
Erika Yamashita
Jinan Behnan
ResearchOpen Access03 Oct 2025
Nature Neuroscience

Volume: 28, P: 2231-2246
Levels of phosphorus and patient outcomes

Clinical practice guidelines recommend target serum levels for phosphorus, calcium and parathyroid hormone in patients with chronic kidney disease. However, a recent meta-analysis has found that only levels of phosphorus seem to be associated with the risk of death in these patients.

Robert N. Foley
News & Views28 Jun 2011
Nature Reviews Nephrology

Volume: 7, P: 428-430
Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis

Using data from a single time point, passenger-approximated clonal expansion rate (PACER) estimates the fitness of common driver mutations that lead to clonal haematopoiesis and identifies TCL1A activation as a mediator of clonal expansion.

Joshua S. Weinstock
Jayakrishnan Gopakumar
Siddhartha Jaiswal
Research12 Apr 2023
Nature

Volume: 616, P: 755-763
The trans-ancestral genomic architecture of glycemic traits

A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.

Ji Chen
Cassandra N. Spracklen
Cornelia van Duijn
Research31 May 2021
Nature Genetics

Volume: 53, P: 840-860
Polygenic prediction of body mass index and obesity through the life course and across ancestries

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Roelof A. J. Smit
Kaitlin H. Wade
Ruth J. F. Loos
ResearchOpen Access21 Jul 2025
Nature Medicine

Volume: 31, P: 3151-3168
A new thermometer for external galaxies

Robert N. Martin
Paul T. P. Ho
K. Ruf
Research15 Apr 1982
Nature

Volume: 296, P: 632-633
Accelerated evolution of a false-truffle from a mushroom ancestor

Thomas D. Bruns
Robert Fogel
Jeffrey D. Palmer
Research11 May 1989
Nature

Volume: 339, P: 140-142
Towards fair decentralized benchmarking of healthcare AI algorithms with the Federated Tumor Segmentation (FeTS) challenge

Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

Maximilian Zenk
Ujjwal Baid
Spyridon Bakas
ResearchOpen Access08 Jul 2025
Nature Communications

Volume: 16, P: 1-20

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