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Multi-ancestry genome-wide association meta-analysis of major depression identifies new risk loci, assesses the transferability of risk loci across ancestry groups, and improves fine-mapping resolution and prioritization of candidate effector genes.

A national programme of recording of Aboriginal rock art sites has been accepted by the Australian Institute of Aboriginal Studies as one of its principal research priorities.

Traditional catalytic studies typically rely on steady-state conditions, producing time-averaged data that cannot distinguish between active species and spectators. Here, the authors explore CO oxidation on Pt(111) by simultaneously monitoring reaction products, surface intermediates, and catalyst responses in real time.

Self-incompatibility prevents inbreeding in flowering plants. In the genus Citrus, there are both self-incompatible and self-compatible species. Now, the molecular mechanism and evolutionary perspectives are revealed to explain the heterogeneity of self-recognition in citrus.

The role of IFN signaling in SARS-CoV-2 infection and outcome is still debated. Here, the authors longitudinally profiled plasma samples from hospitalized patients and show that a persistent inflammatory response is linked to delayed generation of adaptive immunity and increased risk of death when coupled with severe infection.

Here the authors identify a generic coupling in phase-separated liquids between motility and phase equilibria perturbations: phase-separated droplets swim to their dissolution. This suggests alternative transport mechanism for biomolecular condensates.

The brain dynamically transforms cognitive information. Here the authors build task-performing, functioning neural network models of sensorimotor transformations constrained by human brain data without the use of typical deep learning techniques.

An implanted device in the brain enables wireless neural monitoring and stimulation for up to 15 months following implantation.

Cardiovascular events are the main cause of mortality in patients with metabolic dysfunctionassociated steatohepatitis (MASH). Here, the authors show that lanifibranor improves cardiometabolic health - insulin sensitivity, lipid and glucose metabolism, systemic inflammation and hepatic steatosis.

Thermal contraction effect increases with time dominates the long-term deformation trend of the Heber geothermal field, while pressure effects of pressure fluctuation and poroelastic responses keep relatively stable and drive short-term changes.

The East Antarctic ice sheet retreated at the end of the last glacial period. Terrestrial and marine data suggest that the retreat began 14,000 years ago, indicating that the East Antarctic ice sheet probably did not contribute to meltwater pulse 1a 14,700 years ago.

Tailored to detect and prevent potential medication direction errors in a digital pharmacy data processing pipeline, a large language model is shown to increase efficiency and decrease burden for technicians and pharmacists in a prospective application.

TSPO PET imaging is widely used to quantify microglial activation. Here, the authors show that TSPO expression increases in activated rodent but not human microglia, implying that in humans TSPO informs on microglial density rather than activation status.

The evolution of myeloid malignancies is investigated using combined single-cell sequencing and immunophenotypic analysis.

An article in JGR Solid Earth uses numerical models to explore the conditions required to form thick, cratonic lithosphere in a relatively hot Archean mantle.

This work presents NeoLoopFinder, a computational method, for identifying chromatin interactions of structurally rearranged genomes. NeoLoopFinder was applied in 50 cancer datasets and identified genes associated with enhancer-hijacking events.

Here the authors report the cryoEM structure of the RAD51 nucleoprotein filament bound to the C-terminal TR2 domain of BRCA2. The structure explains how BRCA2 stabilises the filament and uncovers a conserved mechanism of filament binding by recombination mediators.

Systems genetics reveals interactions between host and microbial phenotypes in the murine gut, including a role for Akkermansia muciniphila in the production of immunomodulatory ornithine lipids.

Shukla and colleagues show that the Arid1a-dependent BAF chromatin remodeling complex is required to maintain germinal center B cell programs.

Robert P. Crease harks back to the shapers of our scientific infrastructure and what they can tell us about how to handle the threat we now face.

Roquin controls T-cell activity through interactions with mRNAs of stimulatory receptors. Structural and functional elucidation of its RNA-binding domain reveals how it interacts with constitutive decay elements in the 3' UTR of its targets to regulate their expression.

A design strategy termed ‘adaptive morphogenesis’ enables a robot inspired by aquatic and terrestrial turtles to adapt its limb morphology and gait to specialize for locomotion in different environments.

The Tibetan Plateau is expanding eastwards, but the modes of deformation are poorly understood. High-resolution seismic images from the region identify localized zones of weak crustal rocks as well as deep faults, implying that deformation occurs through a combination of crustal flow and movement of rigid blocks of crust.

Targeted mass spectrometry enables reproducible and accurate lipid quantification but dedicated software tools to develop targeted lipidomics assays are lacking. Here, the authors develop a targeted lipidomics workbench and lipid knowledgebase for the streamlined generation of targeted assays.

Drawings can vary in abstraction while still being meaningful. Here, the authors leverage a two-player drawing game to evaluate a cognitive account of pictorial meaning in which both visual and social information jointly support visual communication.

In this Review, Auchtung, Hallen-Adams and Hutkins examine the ecological interactions among microorganisms in various fermented foods, how these interactions shape microbial community structure within food ecosystems, and the effects of modern technologies on the microbial and organoleptic properties of fermented foods.

Somatic mutations in MED12 have been implicated as the causal genetic lesion in the majority of uterine leiomyomas. Here, the authors profile the chromatin landscape of matched normal and leiomyoma tissues and find that changes in enhancer acetylation, enhancer-promoter interaction strength, differential enhancer usage and transcription factor AP-1 occupancy are significant drivers of transcriptional dysregulation in MED12 mutant leiomyomas.

Here the authors report that inhibition of de novo fatty acid synthesis by deleting the enzyme Acetyl-CoA-Carboxylase 1 in the intestinal epithelium results in the loss of crypt structures and a specific decline in Lgr5+ intestinal epithelial stem cells.

Elucidation of a multi-enzyme pathway for degradation of the polysaccharide ulvan by Formosa agariphila provides tools to use ulvan biomass from marine algal blooms as feedstock for renewable sources of carbohydrates.

Psychopathy is a disorder that has typically been considered to result from a primary deficit in fear or empathy. Here the authors find that impulsive-antisocial psychopathic traits are correlated with hyper-reactivity of the dopaminergic reward system as measured with positron emission tomography and functional magnetic resonance imaging.

Understanding loss mechanisms in superconducting circuits is crucial for improving qubit coherence. Here the authors use a multimode resonator to study loss mechanisms in thin-film superconducting circuits and demonstrate on-chip quantum memories with lifetimes exceeding 1ms, using Ta thin-films and high-temperature substrate annealing

Oxygen isotopes and whole-rock geochemistry show that the water required to make Earth’s first continental crust was primordial and derived from the mantle, not surface water introduced by subduction.

Unstable transcripts like enhancer RNAs are common in vertebrates. McDonald et al. show that such unstable transcripts are rare in plants and that promoters can function as potent enhancers, suggesting diverse cis-regulatory mechanisms in eukaryotes.