DNA ligase I links newly synthesized DNA fragments. DNA ligase I deficiency causes ubiquitylation of PCNA in yeast and human by the E2 variant Mms26, Ubc47 and the E3 Rad5, which is required for activation of the DNA damage response and cell viability.
- Sapna Das-Bradoo
- Hai Dang Nguyen
- Anja-Katrin Bielinsky