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cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

A massive phonon mode in a high-overtone bulk acoustic wave resonator has been laser cooled close to its ground state. Its robustness to decoherence establishes the potential of these devices for quantum technologies.

The coherent storage and retrieval of a four-wave-mixing normal mode in a hot atomic rubidium vapour may prove to be useful for future information processing schemes.

Multidrug efflux pumps help bacteria survive stress and promote antibiotic resistance. Here, authors define the molecular detail of an anaerobic-connected pump MdtF uncovering acid-responsive activity which may enable toxin control in certain niches.

ATP synthase powers cells by converting proton translocation into energy. Here, authors reveal distinct structural features of the P. aeruginosa ATP synthase that regulate activity and may serve as targets for new antimicrobial therapies.

A flexible micro-electrocorticography brain–computer interface that integrates a 256 × 256 array of electrodes, signal processing, data telemetry and wireless powering on a single complementary metal–oxide–semiconductor substrate can provide stable, chronic in vivo recordings.

Here the authors provide an explanation for 95% of examined predicted loss of function variants found in disease-associated haploinsufficient genes in the Genome Aggregation Database (gnomAD), underscoring the power of the presented analysis to minimize false assignments of disease risk.

Integrated single mode lasers capable of extremely narrow linewidths and high output power will enable precision portable quantum, microwave, and sensing applications. Here we demonstrate a simultaneous record low fundamental linewidth and high output power using an integrated Brillouin laser in a meter-scale silicon nitride coil resonator.

The cool sub-Neptune LP 791-18 c, with an equilibrium temperature of 355 K, was found to host a hazy atmosphere, distinct from any other temperate sub-Neptune studied so far. The discovery demonstrates the intrinsic diversity of these worlds.

Brillouin lasing with 0.7 Hz fundamental linewidth is observed by optically exciting a monolithic bus–ring Si₃N₄ waveguide resonator. The Brillouin laser is applied to an optical gyroscope and a low phase-noise photonic microwave oscillator.

The authors demonstrate an exciting technique to cancel the common-mode vibration of a photonic resonator upon optical frequency division to microwave frequencies. The resulting 10 GHz microwave achieves 22.6 dB suppression of vibration noise, without incurring any penalty in phase-noise performance.

Gradient-based hybrid quantum-classical algorithms are often initialised with random, unstructured guesses. Here, the authors show that this approach will fail in the long run, due to the exponentially-small probability of finding a large enough gradient along any direction.

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

Analyses of genome and exome sequencing data identify rare coding and structural variants associated with atrial fibrillation and highlight genetic links between atrial fibrillation and cardiomyopathies.

Managing power exhaust in fusion reactors is a key challenge, especially in compact designs for cost-effective commercial energy. This study shows how alternative divertor configurations improve exhaust control, enhance stability, absorb transients and enable independent plasma regulation.

The supercooling parameter, P, was found to be the best indicator of grain morphology of metallic alloys produced with high solidification velocities. This provides guidance for the design of new alloys for use with additive manufacturing.

More than 10,000 time-division-multiplexed degenerate parametric oscillators are generated using phase-sensitive amplification in a nonlinear optical fibre. They can be used to simulate a coherent Ising machine that could solve difficult computing problems.

Optical frequency combs in the mid-infrared are required for molecular gas detection applications but their realization in compact microresonator-based platforms is challenging. Here, Griffith et al. demonstrate on-chip broadband comb generation on a silicon microresonator spanning from 2.1 to 3.5 μm.

Acoustically opaque glass can regain its transparency through coherently driven fields. Combining experiments and theory, the phononic saturation process is presented as analogous to the spectral hole burning process.

By using a resonant sensor to couple two radio-frequency parametric oscillators behaving as Ising spins, a passive wireless device can implement programmable temperature threshold sensing.

Analysis of a deeply phenotyped, longitudinal cohort of 249 participants elucidates the network of concurrent molecular and macroscopic patterns related to insurgence and course of ME/CFS.

STAARpipeline is a comprehensive framework for flexible and scalable rare-variant association analysis using whole-genome sequencing data and annotation information.

Adaptive optics (AO) corrects sample aberrations and allows high spatial resolution at depth in vivo. Here the authors report an AO method for Bessel focus; they apply AO Bessel focus scanning fluorescence microscopy to volumetric imaging and measure synaptic calcium and glutamate activity in vivo.

The tumour-suppressor protein BRCA2 is discovered to have a previously undescribed role in maintaining genomic integrity and the sensitivity of PARP1 inhibitors.

Observations of SN 2021yfj reveal that its progenitor is a massive star stripped down to its O/Si/S core, which remarkably continued to expel vast quantities of silicon-, sulfur-, and argon-rich material before the explosion, informing us that current theories for how stars evolve are too narrow.

Platelet aggregation is associated with myocardial infarction and stroke. Here, the authors have conducted a whole genome sequencing association study on platelet aggregation, discovering a locus in RGS18, where enhancer assays suggest an effect on activity of haematopoeitic lineage transcription factors.

The authors showcase an optical-to-microwave conversion method using an optomechanical waveguide integrated with a piezoelectric transducer. The presented system allows bidirectional optical-to-microwave conversion with a quantum efficiency of up to—54.16 dB.

Two monolayers of bismuth-containing cuprate will form a high-temperature topological superconductor when stacked with an approximately 45° rotation between the layers.

A study shows that clonal haematopoiesis of indeterminate potential is associated with an increased risk of chronic liver disease specifically through the promotion of liver inflammation and injury.

Analysis of whole-genome sequences of 25,465 individuals of European ancestry shows that rare variants contribute substantially to the heritability of height and body mass index.

Although the common genetic variants contributing to blood lipid levels have been studied, the contribution of rare variants is less understood. Here, the authors perform a rare coding and noncoding variant association study of blood lipid levels using whole genome sequencing data.

Pooling participant-level genetic data into a single analysis can result in variance stratification, reducing statistical performance. Here, the authors develop variant-specific inflation factors to assess variance stratification and apply this to pooled individual-level data from whole genome sequencing.

Photoluminescence from plasmonic nanostructures exhibits diverse wavelength dependent nonlinear behaviors with debated origins. Here, authors use plasmonic gap mode resonators with precise nanoscale confinement to show this nonlinear emission can become dominated by non-Fermi carrier contributions.

Using data from a single time point, passenger-approximated clonal expansion rate (PACER) estimates the fitness of common driver mutations that lead to clonal haematopoiesis and identifies TCL1A activation as a mediator of clonal expansion.

Neural wearables can enable life-saving drowsiness monitoring. This work showcases an in-ear, dry-electrode earpiece used to monitor drowsiness for 35 hours across 9 subjects. This data was used to train offline machine learning classifiers and achieve an average accuracy of >90% across all models.

Researchers experimentally demonstrate a fully integrated coherent optical neural network. The system, with six neurons and three layers, operates with a latency of 410 ps.

A study that tracked mammal populations before, during and after a severe storm in Mozambique’s Gorongosa National Park finds that behavioural responses and survival are linked to body size, with increased mortality of small species owing to limited mobility and changes in food availability.

The influence of X chromosome genetic variation on blood lipids and coronary heart disease (CHD) is not well understood. Here, the authors analyse X chromosome sequencing data across 65,322 multi-ancestry individuals, identifying associations of the Xq23 locus with lipid changes and reduced risk of CHD and diabetes mellitus.

Pulse tube refrigerators are a critical enabling technology for many disciplines that require low temperatures, including quantum computing. Here, the authors show that dynamically optimizing the acoustic parameters of the refrigerator can improve conventional cooldown speeds up to 3.5 times.

Chromosomal instability occurs frequently in cancer, making it an attractive therapeutic target. Here, the authors identify KIF18A as a targetable vulnerability of cancer cells with chromosomal instability and target this using VLS-1272, a selective KIF18A inhibitor.

A promising strategy for scaling trapped-ion-based quantum technologies is to use fully integrated optical waveguides to deliver light to numerous ions at multiple sites. Here, the authors. optically address three ions using on-chip waveguides to deliver three distinct wavelengths per ion, and perform Rabi flopping on each ion simultaneously.

The tidal disruption event AT2019dsg is probably associated with a high-energy neutrino, suggesting that such events can contribute to the cosmic neutrino flux. The electromagnetic emission is explained in terms of a central engine, a photosphere and an extended synchrotron-emitting outflow.

Findings from an umbrella review of more than 100 meta-analyses suggest that screen time can have both positive and negative associations with educational and health outcomes for youth, but effect sizes are small.

The goals, resources and design of the NHLBI Trans-Omics for Precision Medicine (TOPMed) programme are described, and analyses of rare variants detected in the first 53,831 samples provide insights into mutational processes and recent human evolutionary history.

 A transcriptomic cell-type atlas of the whole adult mouse brain with ~5,300 clusters built from single-cell and spatial transcriptomic datasets with more than eight million cells reveals remarkable cell type diversity across the brain and unique cell type characteristics of different brain regions.