Kasuya et al. identified a novel KCNE family member, KCNE6, in zebrafish, which is expressed in the heart and contributes to cardiac excitability by producing a slowly activating current with KCNQ1, similar to the IKs current. This discovery enhances understanding of the evolutionary role of KCNE family members in modulating KCNQ1 and provides insights into the physiological diversity of potassium channel regulation across vertebrates.
- Go Kasuya
- Buntaro Zempo
- Koichi Nakajo
