The crystal structure of FANCL, the catalytic subunit of the Fanconi Anemia core complex, reveals an unexpected domain architecture. The molecule comprises an N-terminal E2-like fold, a novel double-RWD domain, which is found to be responsible for substrate binding, and a C-terminal RING domain that is predicted to facilitate E2 binding.
- Ambrose R Cole
- Laurence P C Lewis
- Helen Walden
