Owens et al. reported PFI-7, a selective and potent antagonist of GID4 of the CTLH E3 ligase complex, which enables identification of human GID4 targets. This study provides valuable insights into GID4 functions and a powerful tool for advancing new targeted protein degradation strategies.
- Dominic D. G. Owens
- Matthew E. R. Maitland
- Cheryl H. Arrowsmith
