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Tandem electro-biocatalytic systems present a versatile platform for producing a variety of synthetic products using CO₂ as a starting material. Here direct ocean carbon capture is incorporated into an electrolysis scheme to produce formic acid from CO₂ dissolved in seawater that is subsequently converted to succinate in a bioreactor.

Tools for precisely manipulating phase-separated condensates remain limited. Here authors present an engineered system based on the androgen receptor, where clinically used drugs can be used to control the formation and dissolution of synthetic condensates, subsequently allowing control over various cellular processes.

The authors develop a molecular dopant to avoid the dimerization of the electron-selective material phenyl-C₆₁-butyric acid methyl ester, resulting in enhanced stability and efficiency in inverted perovskite solar cells.

Genotype-phenotype data from over 450,000 individuals was analyzed to discover 205 genomic loci where an allele associated with increase adiposity was associated with a lower cardiometabolic disease risk to an individual.

The authors explore a lithography-like technique in roll-to-roll processing for high-throughput manufacturing of flexible thin-film micro-patterns. They introduce a sputtering-co-evaporation method that enhances both patterning and performance of Bi-Sb-Te-based thermoelectrics.

Type 2 diabetes predisposes individuals to multiple comorbidities, but causal mechanisms are unclear. Here, the authors use Mendelian randomisation to show that distinct genetic pathways underlie diabetes-related risks, with ancestry-specific differences.

This study incorporates local ancestry into the Genome Aggregation Database (gnomAD) to improve allele frequency estimates for admixed populations, enhancing variant interpretation and enabling more accurate and equitable genomic research and clinical care.

In terahertz sideband generation, an electron–hole pair is accelerated in a semiconductor by a terahertz field to then recombines forming a frequency comb, but so far experimental realizations have relied on the large fields of free electron lasers. Here, Crosse et al.propose bi-layer graphene for sideband generation at lower fields.

Desmosomes are adhesive junctions in tension prone tissues. Here, the authors show that cytoskeletal forces alter the conformation of desmoplakin, a key desmosomal protein, and propose this may enable the desmosome to sense and respond to mechanical stimuli.

It is experimentally challenging to observe an intermediate liquid in solid–solid phase transitions due to short lifetimes of the resulting metastable states. Here, Linet al. show that a metastable bismuth liquid can be formed from a crystalline solid through decompression and maintained for hours.

In situ and computational methods are used to investigate the nature of the dense liquid phase of calcium carbonate and its transformation to the amorphous phase that is common in biomineralization processes.

This work presents SCIGEN, a machine learning framework integrating geometric constraints into material generation. The framework enables the discovery of stable quantum material candidates, and the authors synthesize two predicted magnetic materials.

The limited routes for polar texture engineering in materials restrict energy efficient applications. Here, the authors establish lattice chemistry control and the use of polarizing surfaces to manipulate electric dipole ordering in thin films.

The microscopic picture of how superconductivity is linked to antiferromagnetic order in Fe-based compounds remains elusive. Here, Mannaet al. report superconducting correlations which spatially coexist with bi-collinear antiferromagnetic order in a one unit cell thin layer of FeTe grown on Bi₂Te₃.

Lactobacillus-based probiotics have been reported to be beneficial for colitis through incompletely understood mechanisms. Here the authors identify an uncharacterized secreted enzyme named LPH from multiple probiotic Lactobacillus strains, which protects female mice from chemically induced colitis and colorectal cancer via NOD2 signalling.

An inherently explainable AI trained on 1,015 expert-annotated prostate tissue images achieved strong Gleason pattern segmentation while providing interpretable outputs and addressing interobserver variability in pathology.

A screening approach finds VH-domain antibodies that bind the SARS-CoV-2 Spike protein receptor-binding domain at its interface with host ACE2. Bi-paratopic and multivalent binders have high affinity and potency.

Nimbus, a deep learning model, uses a large multiplexed imaging dataset to predict the likelihood of marker positivity in single cells.

A topologically protected state can exist at the interface between a topological insulator and an ordinary insulator. Here, the authors use photoemission spectroscopy to show that the topological Dirac-cone state migrates from the surface of the topological insulator TlBiSe₂to an attached bismuth film.

Dual cyclin A/B RxL inhibitors selectively kill small cell lung cancer cells and other cancer cells with high E2F activity.

When a charge current, a temperature gradient and a magnetic field are applied orthogonally to each other, a conductor is expected to heat or cool. This so-called transverse Thomson effect has now been observed for a bismuth–antimony alloy.

Magnetic nanoparticles are studied for their potential use in nanomagnetic devices. Here the realization of antiferromagnetic coupling in core-shell nanoparticles adds a new possibility to tune their magnetic properties even without changing the structure or morphology.

TFE3-fusions are known to drive both epithelial and mesenchymal renal tumors. Here, the authors generate a transgenic mouse model of renal tumorigenesis expressing the human SFPQ-TFE3 fusion, showing that the fusion regulates mTORC1 activity and induces lineage plasticity.

This bi-ancestral genome-wide association study of major depressive disorder (MDD) identified 178 risk variants. The results advance understanding of the biology of MDD and hint at new treatment possibilities.

Simon, Bugos and colleagues report the design and characterization of monospecific and bispecific synthetic chimeric T cell receptors, conferring increased antigen sensitivity and antitumor activity in B cell malignancies and multiple myeloma models.

Germline mutations in homologous recombination (HR) DNA repair genes are linked to breast and ovarian cancer. Here, the authors show that mutually exclusive bi-allelic inactivation of HR genes are present in other cancer types and associated with genomic features of HR deficiency, expanding the potential use of HR-directed therapies.

Disturbances in IP3 receptor-mediated release of Ca²+ from the endoplasmatic reticulum are associated with neurodegenerative disease. Here, the authors identify in four families with hereditary spastic paraplegia biallelic mutations in RNF170 that associate with increased basal levels of IP3 receptors.

Van Hove singularities have the potential to drive unconventional magnetic states in Kagomes. Here, the authors provide experimental and theoretical results suggesting a van Hove singularity-assisted spin density wave in the Kagome metal CeTi₃Bi₄.

The mismatched bilateral bond strength between NiO_x and perovskite hinders the development of inverted perovskite solar cells. Here, authors adsorb 1-(benzothiaxole-2-ylthio)succinic acid on NiO_x surface for passivating bilateral defects and achieve maximum efficiency close to 27% in stable devices.

Here the authors show a synchronized single-shot bi-modal x-ray and proton source based on laser-generated plasma. This source can be useful for radiographic and tomographic imaging.

The authors present scanning tunnelling spectroscopy data that show that the mechanism of superconductivity in overdoped cuprate superconductors is qualitatively different from conventional mean-field theory.

The thermoelectric material Mg₃Bi₂ is shown to be ductile in single-crystal form along certain directions, with a room-temperature tensile strain of 100%, which is attributed to the gliding of dislocations.

Indonesian cattle are unique due to their history of admixture involving both zebu and banteng. Here, Wang et al. identify ~3.5 million novel introgressed SNP variants and provide a genomic map of banteng introgression within and across many cattle breeds, each with unique introgression histories.

Elastoviscoplastic fluids combine solid- and liquid-like behaviour depending on applied stress. Simulations of elastoviscoplastic fluids at high Reynolds number now show that plasticity plays a key role in the turbulent flows seen in these systems, leading for example to intermittency.

Here the authors construct an artificial pathogen cell with tunable rigidity and find crosstalk between these and macrophages. Macrophages probe the artificial pathogen surface, and increasing rigidity of the artificial pathogen promotes proinflammatory polarization of macrophages.