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Raman optical activity (ROA) is useful for studying conformational structure and behavior of chiral molecules, but is limited by the weak signals. Here, the authors demonstrate 100x signal enhancement via an all-dielectric approach, using a silicon nanodisk array and exploiting its dark mode.

Detailed knowledge of the low-energy electronic structure is required to understand the Mott insulating phase of Ca₂RuO₄. Here, Sutter et al. provide directly the experimental band structure of the paramagnetic insulating phase of Ca₂RuO₄and unveil the electronic origin of its Mott phase.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

Engineered pyroptotic vesicles formed during tumour cell pyroptosis and engineered as personalized tumour vaccines can activate a robust antitumour immune response for post-surgical tumour recurrence inhibition.

The conversational diagnostic artificial intelligence system AMIE (Articulate Medical Intelligence Explorer) has potential as a real-world tool for clinical history-taking and diagnostic dialogue, based on its performance in simulated consultations.

Understanding the physics of transition metal oxides that move beyond the commonly studied 3d orbital state is important for future studies. Taking the (CaCu₃)B₄O₁₂ family as an example, Meyers et al.examine the electronic and magnetic structure as the B-site changes from Co to Rh and Ir.

Insights into Late-Pleistocene Northern Hemisphere storm track variability are hampered by a lack of well-dated proxy records. Here, the authors present a precisely dated record of meteoric precipitation between 30 and 14.7 ka, and show that obliquity may have played a vital role in Alpine glacier advance.

Crystal structures of cyanobacterial protochlorophyllide oxidoreductases reveal the basis of the photocatalytic activities of this enzyme, through the role of its active site in enabling the light-driven reduction of protochlorophyllide.

Materials that can alter their structure in response to light have potential as functional materials such as motors and actuators. Here the authors describe a low-cost system capable of rapid, reversible and wavelength-selective responses to light.

The relationship between electronic ordering and superconductivity, crucial to understand high-T_c superconductors, remains elusive. Here, Sun et al. report the pressure-induced dome shape of a magnetic phase superceding the nematic order in FeSe, suggesting competing nature between magnetism and superconductivity.

Chiral metasurfaces have been produced, with experimental observation of intrinsic chiral bound states in the continuum, which may lead to applications in chiral light sources and detectors, chiral sensing, valleytronics and asymmetric photocatalysis.

Previously, OLIG2-expressing stems cells have been identified as having a role in medulloblastoma recurrence. Here, the authors investigate the effects of targeting this OLIG2+ stem cell population in Sonic Hedgehog (SHH) medulloblastoma using CT-179, an OLIG2 inhibitor.

Donor exciton delocalization and its impact on photovoltaic performance of organic solar cells remains less explored. Here, the authors found that delocalized excitons are formed in aggregates of the donor polymer D18, and that these delocalized excitons mediate charge generation in solar cells.

The nature of unconventional charge density wave in kagome metals is currently under intense debate. Here the authors report the coexistence of the 2 × 2 × 1 charge density wave in the kagome sublattice and the Sb 5p-electron assisted 2 × 2 × 2 charge density waves in CsV₃Sb₅.

Machine learning can be used to identify subtypes of psychiatric disease. Here the authors identified two neurostructural subgroups in schizophrenia, each showing reproducibility and generalizability across different collection locations and illness stages, using the SuStain algorithm.

Current approaches to detect allograft damages non-invasively are limited and do not differentiate between cellular mechanisms. Here, the authors show that the composition of cell-free DNA in blood samples can reveal cellular causes of allograft injury after liver transplant.

Angle-resolved photoemission spectroscopy of superconducting magic-angle twisted bilayer graphene reveals flat-band replicas that are indicative of strong electron–phonon coupling; these replicas are absent in non-superconducting twisted bilayer graphene.

Psoriasis is a skin disease associated with neurogenic inflammation. Here, the authors activation of ASIC3 on sensory neurons that leads to the release of CGRP, which triggers inflammation through dendritic cells and drives psoriatic inflammation.

Extending matter-wave interferometry to nanoscale objects requires beam splitters that can cope with their internal complexity. Here, the authors demonstrate that the absorption of individual photons allows the center-of-mass coherence of large molecules to be maintained.

Defect-free monolayers of graphene and hexagonal boron nitride are highly permeable to thermal protons, but are impenetrable to gases. Here the authors show that mechanically exfoliated crystals exhibit perfect proton selectivity, corroborating proton transport through the bulk without atomic-scale defects.

Photonic circuits often require separate components to manipulate light with orthogonal polarization, but this increases the chip size. Here, the authors create a polarization-dependent beam-splitter that uses dielectric loaded plasmonic waveguides to handle both polarizations in the same component.

Magnetic reconnection is a fundamental energy release process taking place in various astrophysical environments, but it is difficult to observe it directly. Here, the authors provide evidence of three-dimensional magnetic reconnection in a solar eruption using combined perspectives of two spacecraft.

The mechanisms underlying optimal transcriptional activation remain elusive. Here, the authors show that CRISPR-SunTag activators form liquid-like droplets and boost gene expression, while increased SunTag scaffolds creates solid-like condensates that sequester coactivators, impairing activation.

Cheng et al. developed a computer vision tool (SeeMe) that detects low-amplitude facial movements in comatose brain injury patients. Purposeful responses are detected days before clinical detection, suggesting that covert consciousness may often go unrecognized.

Weyl semimetals are interesting because they are characterized by topological invariants, but specific examples discovered to date tend to have complicated band structures with many Weyl points. Here, the authors show that TaIrTe₄ has only four Weyl points, the minimal number required by time-reversal symmetry.

Artificial intelligence (AI) is becoming increasingly relevant to assist with oncology imaging, but diagnosing rare tumours remains challenging. Here, the authors develop an AI approach to detect rare thyroid cancer subtypes by integrating clinical knowledge with image generation based on ultrasound imaging data from large patient cohorts.

Liquid crystal monomers are emerging contaminants; however, whether they can cross the placenta and affect placental development remains unexplored. Here, the authors show SLC16A10- mediated transplacental transportation of LCMs inhibits placental development and progesterone release.

Spin ices are magnetic materials in which excitations equivalent to monopoles can occur. Using high-pressure techniques, Zhouet al. synthesize a new member of the spin ice family, Dy₂Ge₂O₇, in which monopoles exist at higher densities, and can stabilize as dimers.

Space charge influences significantly the energy storage and insulation of dielectric materials, yet its distribution in micron-scale films remains poorly understood due to measurement limitations. Here, the authors utilize picosecond laser induced pressure-wave propagation technology to achieve high-resolution mapping, revealing insights into charge distribution and guiding the development of robust dielectrics for diverse applications.

The overlap between different phases has hindered the understanding of how each phase affects superconductivity in FeSe. Here, Matsuura et al. achieve a complete separation of non-magnetic nematic and antiferromagnetic phases for FeSe_1-x S _x , observing a tetragonal phase in between with a strikingly enhanced T _c.