Inhibiting the progression of rapidly dividing cancer cells through the cell cycle has long been pursued as an anticancer strategy. Dobbelstein and Sørensen discuss an alternative approach based on exploiting inherent defects in the DNA replication machinery in cancer cells to promote replicative stress and cell death, and discuss how agents that increase replicative stress might be useful either alone or in combination with conventional chemotherapeutics.
- Matthias Dobbelstein
- Claus Storgaard Sørensen
