Search

Electrochemical CO reduction to multi-carbon products offers a carbon-negative approach to produce chemicals, but the intricate reaction pathways lead to a broad spectrum of products. Now it has been shown that alkali cations alter the mechanistic pathways that govern the reaction selectivity involved in the formation of hydrocarbons versus oxygenates.

Prima is an AI foundation model for neuroimaging based on clinical magnetic resonance imaging that offers accurate and explainable diagnostics, worklist priority for radiologists and clinical referral recommendations with equitable performance on diverse groups.

Silicon anodes promise much higher battery capacity but are limited by poor storage life. This work identifies key ageing mechanisms and suggests ways to improve long-term stability.

Topological metamaterial clothing based on metallic conductive textiles can be used to create robust biosensing networks on the human body that can monitor vital signs during exercise.

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

Energy deposition inside silicon with ultrashort laser pulses is intrinsically restricted. Here, authors demonstrate that this filamentation-driven ceiling is universal in semiconductors. Extreme nonlinearities are quantified to predict and optimize involume laser-semiconductor interaction.

An amino-acid-encoded assembly strategy is developed for the synthesis of programmable chiral Solomon links, featuring tunable cavity dimensions and shapes. This template-free synthetic approach favours homochiral assembly over non-chiral or heterochiral pathways. The resulting interlocked molecules exhibit strong chiral amplification and exceptional enantioselective peptide recognition.

Behçet’s syndrome is a chronic inflammatory disease with oral ulcers being the most common symptom. Here authors present results from a phase 2 randomized double-blind placebo-controlled clinical trial that shows that systemic low dose interleukin-2 could be safely administered to these patients, and the therapy may improve their quality of life.

A global synthesis of >600 studies finds that across agro-ecosystems, grasslands and forests in temperate and tropical zones, increasing plant diversity has a consistently positive effect on plant performance and the suppression of antagonists.

This study shows that WDR5 remodels NANOG condensates to control transcriptional programs. Disrupting their interaction compromises stem cell identity and suppresses leukemia stem cell expansion.

In this randomized phase 3 trial, patients with treatment-naive stage III–IV nonsmall cell lung cancer who received sintilimab or pembrolizumab in combination with chemotherapy early in the day (before 15:00 h) experienced longer progression-free survival compared with those receiving late time-of-day infusions.

In the phase III NAPOLI-3 trial, first-line treatment with NALIRIFOX was associated with improved overall survival compared to gemcitabine plus nab-paclitaxel in patients with metastatic pancreatic adenocarcinoma. Here the authors report the results of a randomized phase II trial comparing the two regimens, NALIRIFOX versus Gemcitabine plus Nab-Paclitaxel, in Chinese patients.

Cardiometabolic disease and depression often co-occur, but their multi-organ basis was unclear. Here, the authors analyse UK Biobank imaging and genetics, identifying abdomen-heart-brain networks and 43 shared loci, improving multimorbidity prediction

Yakut communities, with Trans-Baikal admixture during the Mongol expansion, preserved genomic diversity and oral microbiomes despite the Russian conquest, which introduced cereals, pathogens and Christianity, whereas marital practices preserved low consanguinity except in one late case of traditional shamanism.

Here the authors spatially map tuberculosis granulomas from nonhuman primates to link structure and immune organization with bacterial control. They find that a conserved hypoxic myeloid core is associated with dysfunctional immunity, restricted lymphocyte access and increased bacterial burden.

A non-coplanar axially chiral molecular contact favours the crystalline growth of perovskite film and improves interfacial stability in perovskite solar cells. Small-area devices yield a certified power conversion efficiency of 26.44% and maintain 98% of it after 2,000 hours of operation.

O-GlcNAc chromatin modifications dynamically reshape the transcriptional program of oncogene-induced senescence, forming complexes that activate SASP genes and repress cell-cycle genes; JUN and GATAD2A are identified as key regulators.

A bioresorbable microneedle sensor array provides continuous, wireless and multimodal monitoring of organ metabolism, oxygenation and electrophysiology for up to 7 days in postoperative kidney ischaemia and gut disorders.

Researchers studied the blood-based metabolome of over 23,000 people from ten ethnically diverse cohorts. They identified 235 metabolites associated with future risk of type 2 diabetes (T2D). By integrating genetic and modifiable lifestyle factors, their findings provide insights into T2D mechanisms and could improve risk prediction and inform precision prevention.

Identifying modifiable factors for cardiovascular health is becoming increasingly important. Here, the authors demonstrate that eating within shorter, earlier time windows is associated with lower cardiovascular risk in Chinese children. Multi-omics analysis suggests that lipid metabolism pathways may mediate these effects.

Significant amounts of food waste are generated, and although composting is a useful route for such waste, the process is long. Here, the authors report the development of a microwave-assisted method for the rapid humification of waste potato, resulting in a fluvic acid-like fertiliser.

Protein kinases contribute to hepatocellular carcinoma progression and immune evasion. This study identifies SPAK as a key driver of oncogenesis and immune exhaustion, showing that SPAK inhibition synergizes with anti-PD-1 therapy to enhance antitumor efficacy.

An in situ multistep edge-contact process is developed for MoS₂ transistors, achieving quasi-non-volatile capacitorless two-transistor dynamic random-access memory with 5-bit accuracy and nanosecond write speeds.

Reusing materials from spent lithium-ion batteries is a key strategy for developing a sustainable supply chain, but we need to deepen our understanding of the associated environmental impacts. Now, a model-based analysis shows that pretreating end-of-life batteries is critical for enhancing the sustainability of recycling.

Here the authors report a phase 3 clinical trial showing that Ecnoglutide, designed as a cAMP-biased GLP-1R agonist, improved glycaemic control versus placebo in adults with type 2 diabetes inadequately controlled with diet and exercise alone or with a single oral hypoglycaemic agent.

Lampreys are jawless vertebrates that can offer unique insights into vertebrate evolution. Here they generate a comprehensive cell atlas of the lamprey, uncovering 70 distinct cell types across 14 tissues, and identify pancreas-like cells in the lamprey small intestine.

Terahertz microspectroscopic imaging at subgap millielectronvolt energies of a two-dimensional superfluid plasmon in few-layer Bi₂Sr₂CaCu₂O_8+x is demonstrated, allowing the spatial resolution of its deeply subdiffractive terahertz electrodynamics.

Medullary thyroid carcinoma (MTC) is a rare and aggressive neuroendocrine tumor with limited risk stratification. Here, the authors perform multi-omic analysis of MTC samples from 452 patients across 10 Chinese clinical centers, identify molecular subtypes and develop a prediction model.

Luppi et al. identify transcriptomic and connectomic controllers of information integration and its breakdown induced by anaesthesia in humans, macaques, marmosets and mice.

The study of the interplay between topological states and correlated states such as charge density waves (CDW) requires a thorough understanding of their electronic structure. In this work, the authors resolve the fully CDW reconstructed electronic structure of TaTe4, a candidate topological material, using a combined theoretical and experimental approach based on magnetotransport measurements, which also reveal the existence of large magnetic breakdown orbits and linear magnetoresistance.