Nature Search

Myoinositol in Human Neonates: Serum Concentrations and Renal Handling

L M Lewin
S Melmed
H Bank
Research01 Jan 1978
Pediatric Research

Volume: 12, P: 3-6
Measured Velocities of Interplanetary Dust Particles

C. S. NILSSON
W. M. ALEXANDER
L. SECRETAN
Research13 Nov 1965
Nature

Volume: 208, P: 673-674
Pathogenesis of pituitary tumors

Pituitary tumors arising from differentiated hormone-expressing cells are commonly encountered, are mostly sporadic and are invariably benign. Improved understanding of the mechanisms that underlie pituitary tumorigenesis will enable development of tumor aggression markers as well as novel targeted therapies. This Review describes these mechanisms, which result in cell cycle dysregulation, signaling defects or loss of tumor suppressor factors.

Shlomo Melmed
Reviews22 Mar 2011
Nature Reviews Endocrinology

Volume: 7, P: 257-266
A new partnership

Paul Stewart
P Reed Larsen
Editorial01 Jan 2006
Nature Clinical Practice Endocrinology & Metabolism

Volume: 2, P: 1
Isolation of tumour stem-like cells from benign tumours

Q Xu
X Yuan
J S Yu
ResearchOpen Access30 Jun 2009
British Journal of Cancer

Volume: 101, P: 303-311
Pauling's model not universally accepted

JOHN W. CAHN
DENIS GRATIAS
DAN SHECHTMAN
Research09 Jan 1986
Nature

Volume: 319, P: 102-103
Acromegaly with moderate hyperprolactinemia caused by an intrasellar macroadenoma

Vivien S Bonert
Shlomo Melmed
Reviews01 Jul 2006
Nature Clinical Practice Endocrinology & Metabolism

Volume: 2, P: 408-412
A Consensus Statement on acromegaly therapeutic outcomes

Acromegaly is usually caused by a pituitary adenoma that secretes growth hormone; treatment of acromegaly and its comorbidities is often complex. In this Consensus Statement, Shlomo Melmed and colleagues provide updated recommendations for the treatment of patients with acromegaly.

Shlomo Melmed
Marcello D. Bronstein
Andrea Giustina
ReviewsOpen Access26 Jul 2018
Nature Reviews Endocrinology

Volume: 14, P: 552-561
Consensus on acromegaly therapeutic outcomes: an update

In this Consensus Statement, an international group of experts provide updated recommendations on the treatment of acromegaly, including discussion of treatment outcomes.

Shlomo Melmed
Luigi di Filippo
Andrea Giustina
Reviews13 Aug 2025
Nature Reviews Endocrinology

Volume: 21, P: 718-737
Pituitary tumor transforming gene interacts with Sp1 to modulate G1/S cell phase transition

Y Tong
Y Tan
S Melmed
Research12 Mar 2007
Oncogene

Volume: 26, P: 5596-5605
Future biologic targets for IBD: potentials and pitfalls

IBD treatment has evolved towards biologic therapy, which seeks to target specific immune and biochemical abnormalities at the molecular and cellular level. Improved understanding of the pathogenesis of IBD has suggested future drug biologic targets, which are currently being investigated. This Review article discusses the potentials and pitfalls of biologic therapy for IBD as this field advances at a rapid pace.

Gil Y. Melmed
Stephan R. Targan
Reviews01 Feb 2010
Nature Reviews Gastroenterology & Hepatology

Volume: 7, P: 110-117
Ovarian hyperstimulation syndrome caused by an FSH-secreting pituitary adenoma

Contrary to the assumption that gonadotrope pituitary adenomas are non-functioning, these tumors can be functional and lead to the development of the ovarian hyperstimulation syndrome. This article describes a patient with a 15-year history of galactorrhea and multicystic ovaries caused by a gonadotrope-secreting pituitary adenoma.

Odelia Cooper
Jordan L Geller
Shlomo Melmed
Reviews12 Feb 2008
Nature Clinical Practice Endocrinology & Metabolism

Volume: 4, P: 234-238
Supplemental growth hormone in healthy adults: the endocrinologist's responsibility

Shlomo Melmed
Editorial01 Mar 2006
Nature Clinical Practice Endocrinology & Metabolism

Volume: 2, P: 119
Endocrinology research—reflecting on the past decade and looking to the next

Here, five of our Advisory Board Members look back at the past decade of endocrinology research, highlighting key advances and identifying roadblocks. They also discuss where effort and money should be invested now and speculate on where progress might be made in the coming decade.

Kevan C. Herold
Joseph A. Majzoub
Martin Schlumberger
Reviews13 Oct 2015
Nature Reviews Endocrinology

Volume: 11, P: 672-680
The Effects of Opiate Antagonism on Gonadotropin Secretion in Children and in Women with Hypothalamic Amenorrhea

S E Sauder
G D Case
J C Marshall
Research01 Apr 1984
Pediatric Research

Volume: 18, P: 322-328
Pituitary tumor transforming gene 1 regulates Aurora kinase A activity

Y Tong
A Ben-Shlomo
S Melmed
Research28 Jul 2008
Oncogene

Volume: 27, P: 6385-6395
Author Correction: Acromegaly

Annamaria Colao
Ludovica F. S. Grasso
Rosario Pivonello
Amendments and Corrections21 Oct 2019
Nature Reviews Disease Primers

Volume: 5, P: 1
Erratum: Genome-wide association identifies multiple ulcerative colitis susceptibility loci

Dermot P B McGovern
Agnès Gardet
Mark Seielstad
Amendments and Corrections29 Mar 2011
Nature Genetics

Volume: 43, P: 388
PTTG induces EMT through integrin α_Vβ₃-focal adhesion kinase signaling in lung cancer cells

P P Shah
M Y Fong
S S Kakar
Research14 Nov 2011
Oncogene

Volume: 31, P: 3124-3135
Pituitary incidentaloma: a Pituitary Society international consensus guideline statement

This international Consensus Statement provides guidelines on the management of pituitary incidentalomas.

Maria Fleseriu
Mark Gurnell
Theodore H. Schwartz
Reviews24 Jun 2025
Nature Reviews Endocrinology

Volume: 21, P: 638-655
Effect of Saliva from Cystic Fibrosis Patients and from Normal Subjects on Red Blood Cell Sodium Transport

P M Grinwald
M B Segal
Research01 Jan 1978
Pediatric Research

Volume: 12, P: 1-3
Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction

The authors find that the Avpr1a gene, encoding the vasopressin-1A receptor, is responsible for strain-dependent pain sensitivity of mice to formalin and capsaicin. In humans, a single nucleotide polymorphism in AVPR1A was found to affect capsaicin pain and desmopressin analgesia. In both species, the effects were male specific and dependent on stress levels at the time of testing.

Jeffrey S Mogil
Robert E Sorge
Roger B Fillingim
Research23 Oct 2011
Nature Neuroscience

Volume: 14, P: 1569-1573
Acromegaly

Acromegaly is a hormonal disorder that is usually caused by a growth hormone-secreting pituitary tumour. This Primer by Colao and colleagues reviews the pathogenesis, diagnosis and management of acromegaly and discusses the quality of life of patients and future outlooks.

Annamaria Colao
Ludovica F. S. Grasso
Rosario Pivonello
Reviews21 Mar 2019
Nature Reviews Disease Primers

Volume: 5, P: 1-17
Optimizing the safety of biologic therapy for IBD

Despite the widespread use of biologic therapy for IBD, safety concerns still exist. To realize the full potential of these therapies it is important to select appropriate patients for therapy and to optimize the delivery of these agents, thus maximizing their effectiveness. At the same time it is important to adopt strategies before and during treatment that minimize the occurrence of adverse effects. This Review outlines the adverse events associated with biologic therapies, and gives recommendations on how to reduce the risk of these events.

Shanika de Silva
Shane Devlin
Remo Panaccione
Reviews01 Feb 2010
Nature Reviews Gastroenterology & Hepatology

Volume: 7, P: 93-101
Evaluation of an artificial intelligence-based medical device for diagnosis of autism spectrum disorder

Jonathan T. Megerian
Sangeeta Dey
Sharief Taraman
ResearchOpen Access05 May 2022
npj Digital Medicine

Volume: 5, P: 1-11
Knocking out the stress response

S R Bornstein
A Böttner
G P Chrousos
News08 Oct 1999
Molecular Psychiatry

Volume: 4, P: 403-407
Author Correction: Diagnosis and management of prolactin-secreting pituitary adenomas: a Pituitary Society international Consensus Statement

Stephan Petersenn
Maria Fleseriu
Shlomo Melmed
Amendments and Corrections17 Oct 2023
Nature Reviews Endocrinology

Volume: 20, P: 62
Aggressive pituitary adenomas—diagnosis and emerging treatments

The WHO classification of pituitary tumours (typical adenomas, atypical adenomas and pituitary carcinomas) does not distinguish between aggressive and nonaggressive tumours. This Review highlights the need to recognize aggressive pituitary adenomas as a distinct clinical entity, taking into account not only clinical behaviour, but also histopathological, molecular and radiological features. It also discusses promising biomarkers that might facilitate the early detection of clinically aggressive pituitary tumours and subsequent management of selected patients.

Antonio Di Ieva
Fabio Rotondo
Kalman Kovacs
Reviews13 May 2014
Nature Reviews Endocrinology

Volume: 10, P: 423-435
1216 EFFICACY OF TOLAZOLINE HC1 AS A PULMONARY VASODILATOR IN NEWBORN HYPOXEMIC(Hyp) GOATS

R M Nestrud
J E Fewell
J B Norton
Research01 Apr 1978
Pediatric Research

Volume: 12, P: 566
Expert consensus document: A consensus on the medical treatment of acromegaly

Acromegaly usually occurs owing to a growth-hormone-secreting adenoma in the pituitary gland, which leads to metabolic and anatomical changes in the patient. This Expert Consensus Document outlines the current recommendations for the treatment of acromegaly as determined by the Acromegaly Consensus Group in March 2013.

Andrea Giustina
Philippe Chanson
Shlomo Melmed
Reviews25 Feb 2014
Nature Reviews Endocrinology

Volume: 10, P: 243-248
Direct promoter induction of p19Arf by Pit-1 explains the dependence receptor RET/Pit-1/p53-induced apoptosis in the pituitary somatotroph cells

E Diaz-Rodriguez
M García-Lavandeira
C V Alvarez
Research24 Oct 2011
Oncogene

Volume: 31, P: 2824-2835
Heteroplasmy in Chronic External Ophthalmoplegia: Clinical and Molecular Observations

Orest Hurko
Donald R Johns
C P Lee
Research01 Nov 1990
Pediatric Research

Volume: 28, P: 542-548
Genome-wide association identifies multiple ulcerative colitis susceptibility loci

Mark Seielstad and colleagues report results of a large genome-wide association and replication study of ulcerative colitis. The work identifies several new risk loci for this disease and provides further insight into the shared pathogenesis of ulcerative colitis and Crohn's disease.

Dermot P B McGovern
Agnès Gardet
Mark Seielstad
Research14 Mar 2010
Nature Genetics

Volume: 42, P: 332-337
High-dose busulphan/melphalan with autologous stem cell rescue in Ewing’s sarcoma

A Atra
JS Whelan
CR Pinkerton
Research01 Nov 1997
Bone Marrow Transplantation

Volume: 20, P: 843-846
Ovarian cancer has frequent loss of heterozygosity at chromosome 12p12.3-13.1 (region of TEL and Kip1 loci) and chromosome 12q23-ter: evidence for two new tumour-suppressor genes

Y Hatta
S Takeuchi
HP Koeffler
Research01 May 1997
British Journal of Cancer

Volume: 75, P: 1256-1262
Identification of somatic mutations of the MEN1 gene in sporadic endocrine tumours

L Bergman
C Boothroyd
N Hayward
ResearchOpen Access19 Sept 2000
British Journal of Cancer

Volume: 83, P: 1003-1008
Relationships between IGF-I and age, gender, body mass, fat distribution, metabolic and hormonal variables in obese patients

M Maccario
J Ramunni
E Ghigo
Research26 Jun 1999
International Journal of Obesity

Volume: 23, P: 612-618
Recombinant Human Thyroid Stimulating Hormone: Development of a Biotechnology Product for Detection of Metastatic Lesions of Thyroid Carcinoma

Edward S. Cole
Karen Lee
Bruce M. Pratt
Reviews01 Sept 1993
Bio/Technology

Volume: 11, P: 1014-1024
Influence of chronic Naltrexone treatment on growth hormone and insulin secretion in obese subjects

L De Marinis
A Mancini
A Lanzone
Research01 Nov 1997
International Journal of Obesity

Volume: 21, P: 1076-1081
The GH/IGF-I axis in obesity: influence of neuroendocrine and metabolic factors

M Maccario
S Grottoli
E Ghigo
Research24 Jul 2000
International Journal of Obesity

Volume: 24, P: S96-S99
Diagnosis and management of prolactin-secreting pituitary adenomas: a Pituitary Society international Consensus Statement

This Consensus Statement, which is endorsed by the Pituitary Society, offers evidence-based graded consensus recommendations and key summary points for clinical practice on the diagnosis and management of prolactinomas.

Stephan Petersenn
Maria Fleseriu
Shlomo Melmed
Reviews05 Sept 2023
Nature Reviews Endocrinology

Volume: 19, P: 722-740
Pituitary adenoma or neuroendocrine tumour: the need for an integrated prognostic classification

This Perspective presents the outcomes of an interdisciplinary international workshop that addressed the implications of the WHO classification change of pituitary adenoma to neuroendocrine tumours. The authors propose that a comprehensive classification system be developed integrating clinical, genetic, biochemical, radiological, pathological and molecular information for all anterior pituitary neoplasms.

Ken K. Y. Ho
Ursula B. Kaiser
Shlomo Melmed
Reviews17 Aug 2023
Nature Reviews Endocrinology

Volume: 19, P: 671-678
Maximal secretory capacity of somatotrope cells in obesity: comparison with GH deficiency

M Maccario
MR Valetto
E Ghigo
Research01 Jan 1997
International Journal of Obesity

Volume: 21, P: 27-32
Small intestinal enteropathy with epithelial IgG and complement deposition in children with regressive autism

F Torrente
P Ashwood
S H Murch
Research24 Apr 2002
Molecular Psychiatry

Volume: 7, P: 375-382
Serotonin transporter gene promoter variants do not explain the hyperserotoninemia in autistic children

A M Persico
T Pascucci
F Keller
Research23 Aug 2002
Molecular Psychiatry

Volume: 7, P: 795-800
Mutation and expression analysis of the p27/kip1 gene in corticotrophin-secreting tumours

Patricia LM Dahia
Ricardo CT Aguiar
Ashley B Grossman
Research21 Jan 1998
Oncogene

Volume: 16, P: 69-76
Deconvolution Analysis of Spontaneous Nocturnal Growth Hormone Secretion in Prepubertal Children with Preterminal Chronic Renal Failure and with End-Stage Renal Disease

Burkhard Tönshoff
Johannes D Veldhuis
Otto Mehls
Research01 Jan 1995
Pediatric Research

Volume: 37, P: 86-93
CDKN2A gene inactivation in epithelial sporadic ovarian cancer

D Niederacher
H-Y Yan
M W Beckmann
ResearchOpen Access30 Jul 1999
British Journal of Cancer

Volume: 80, P: 1920-1926
Serum selenium, plasma glutathione (GSH) and erythrocyte glutathione peroxidase (GSH-Px)-levels in asymptomatic versus symptomatic human immunodeficiency virus-1 (HIV-1)-infection

MP Look
JK Rockstroh
T Sauerbruch
Research01 Apr 1997
European Journal of Clinical Nutrition

Volume: 51, P: 266-272
Multiple endocrine defects in adult-onset Sprouty1/2/4 triple knockout mice

Gisela Altés
Anna Olomí
Mario Encinas
ResearchOpen Access22 Aug 2024
Scientific Reports

Volume: 14, P: 1-10

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