Corticosteroids have been used to treat childhood nephrotic syndrome for more than 50 years but a minority of patients, especially those with focal segmental glomerulosclerosis, are resistant to this treatment, This Review summarizes the currently available treatments for both steroid-sensitive and steroid-resistant childhood nephrotic syndrome, and discusses selected novel pathways in podocytes that could be targeted for the development of next-generation treatments for children with this syndrome.
- Larry A. Greenbaum
- Rainer Benndorf
- William E. Smoyer
