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Showing 151–200 of 274 results

Advanced filters: Author: S Pfeifer Clear advanced filters

Precision prognostics for cardiovascular disease in Type 2 diabetes: a systematic review and meta-analysis

Ahmad, Lim, Morieri, Tam et al perform a systematic review and meta-analysis of biomarkers, genetic markers, and risk scores for prediction of cardiovascular outcomes in Type 2 diabetes. A few prognostic markers are identified that provide incremental predictive utility beyond established cardiovascular risk factors.

Abrar Ahmad
Lee-Ling Lim
Nestoras Mathioudakis
ResearchOpen Access22 Jan 2024
Communications Medicine

Volume: 4, P: 1-28
H19 and IGF-2 allele-specific expression in hepatoblastoma

J A Ross
G A Radloff
S M Davies
ResearchOpen Access20 Jan 2000
British Journal of Cancer

Volume: 82, P: 753-756
Characterization of the oligomerization defects of two p53 mutants found in families with Li–Fraumeni and Li–Fraumeni-like syndrome

Timothy S Davison
Peter Yin
Cheryl H Arrowsmith
Research10 Aug 1998
Oncogene

Volume: 17, P: 651-656
DLEC1 is a functional 3p22.3 tumour suppressor silenced by promoter CpG methylation in colon and gastric cancers

J Ying
F F Poon
Q Tao
ResearchOpen Access20 Jan 2009
British Journal of Cancer

Volume: 100, P: 663-669
Avian winged helix proteins CWH-1, CWH-2 and CWH-3 repress transcription from Qin binding sites

Bettina S Freyaldenhoven
Markus P Freyaldenhoven
Peter K Vogt
Research24 Jul 1997
Oncogene

Volume: 15, P: 483-488
RASSF2, a potential tumour suppressor, is silenced by CpG island hypermethylation in gastric cancer

M Endoh
G Tamura
T Motoyama
ResearchOpen Access01 Nov 2005
British Journal of Cancer

Volume: 93, P: 1395-1399
Differential expression of miR-184 in temporal lobe epilepsy patients with and without hippocampal sclerosis – Influence on microglial function

Bénédicte Danis
Marijke van Rikxoort
Patrik Foerch
ResearchOpen Access26 Sept 2016
Scientific Reports

Volume: 6, P: 1-12
Multiple mutations are common at mouse Aprt in genotoxin-exposed mismatch repair deficient cells

Chi Y Shin
Isabel Mellon
Mitchell S Turker
Research08 Mar 2002
Oncogene

Volume: 21, P: 1768-1776
Vitamin D₂ dose required to rapidly increase 25OHD levels in osteoporotic women

S R Mastaglia
C A Mautalen
B Oliveri
Research04 Jan 2006
European Journal of Clinical Nutrition

Volume: 60, P: 681-687
Standardisation and consensus guidelines for minimal residual disease assessment in Philadelphia-positive acute lymphoblastic leukemia (Ph + ALL) by real-time quantitative reverse transcriptase PCR of e1a2 BCR-ABL1

H. Pfeifer
G. Cazzaniga
O. G. Ottmann
Research11 Mar 2019
Leukemia

Volume: 33, P: 1910-1922
A randomized trial of amifostine as a cytoprotective agent in patients receiving chemotherapy for small cell lung cancer

P W M Johnson
M F Muers
J M Brown
ResearchOpen Access03 Jan 2001
British Journal of Cancer

Volume: 84, P: 19-24
Concomitant RASSF1A hypermethylation and KRAS/BRAF mutations occur preferentially in MSI sporadic colorectal cancer

Carla Oliveira
Sérgia Velho
Simo Schwartz Jr
Research11 Jul 2005
Oncogene

Volume: 24, P: 7630-7634
Analysis of measurable residual disease by IG/TR gene rearrangements: quality assurance and updated EuroMRD guidelines

Vincent H. J. van der Velden
Isabel Dombrink
Jacques J. M. van Dongen
ResearchOpen Access14 May 2024
Leukemia

Volume: 38, P: 1315-1322
DNA hypermethylation in lung cancer is targeted at differentiation-associated genes

E Helman
K Naxerova
I S Kohane
Research01 Aug 2011
Oncogene

Volume: 31, P: 1181-1188
Circular dichroism in multiphoton ionization of resonantly excited helium ions near channel closing

René Wagner
Markus Ilchen
Michael Meyer
ResearchOpen Access08 Nov 2024
Scientific Reports

Volume: 14, P: 1-11
Chromosome 3p and breast cancer

Q. Yang
G. Yoshimura
K. Kakudo
Reviews01 Sept 2002
Journal of Human Genetics

Volume: 47, P: 453-459
UV mutation signature in tumor suppressor genes involved in skin carcinogenesis in xeroderma pigmentosum patients

Mariarosaria D'Errico
Angelo Calcagnile
Eugenia Dogliotti
Research21 Jan 2000
Oncogene

Volume: 19, P: 463-467
The role of KCNQ1 in mouse and human gastrointestinal cancers

B L N Than
J A C M Goos
R T Cormier
Research26 Aug 2013
Oncogene

Volume: 33, P: 3861-3868
Regulation of mitosis and taxane response by Daxx and Rassf1

S Giovinazzi
C R Lindsay
A M Ishov
Research06 Jun 2011
Oncogene

Volume: 31, P: 13-26
Perinatal COVID-19 maternal and neonatal outcomes at two academic birth hospitals

Dustin D. Flannery
Alvaro Zevallos Barboza
Karen M. Puopolo
Research01 Jul 2022
Journal of Perinatology

Volume: 42, P: 1338-1345
Cancer-associated hypersialylated MUC1 drives the differentiation of human monocytes into macrophages with a pathogenic phenotype

Beatson et al. show that a sialylated tumour-associated glycoform of the mucin MUC1 induces the differentiation of monocytes into tumour-associated macrophages. These macrophages are found in breast cancer stroma and their presence is associated with poor prognosis.

Richard Beatson
Rosalind Graham
Joy M. Burchell
ResearchOpen Access04 Nov 2020
Communications Biology

Volume: 3, P: 1-15
Precision treatment of beta-cell monogenic diabetes: a systematic review

Naylor et al. systematically review the efficacy of treatments for beta-cell monogenic diabetes. Limited evidence from the mostly non-randomized, small studies supports no treatment in glucokinase-related hyperglycemia and sulfonylureas for HNF1A-diabetes; further evidence is needed on the optimum treatments in these and other monogenic subtypes.

Rochelle N. Naylor
Kashyap A. Patel
Tiinamaija Tuomi
ResearchOpen Access18 Jul 2024
Communications Medicine

Volume: 4, P: 1-17
Effective interventions in preventing gestational diabetes mellitus: A systematic review and meta-analysis

Takele et al. conduct a systematic review and meta-analysis of the effects of intervention characteristics on preventing gestational diabetes. Group or healthcare facility-based physical activity interventions are found to be more effective in preventing gestational diabetes than community-based interventions.

Wubet Worku Takele
Kimberly K. Vesco
Siew Lim
ResearchOpen Access20 Apr 2024
Communications Medicine

Volume: 4, P: 1-15
A sensitive scoring system for the longitudinal clinical evaluation and prediction of lethal disease outcomes in newborn mice

Beate Fehlhaber
Anna S. Heinemann
Dorothee Viemann
ResearchOpen Access11 Apr 2019
Scientific Reports

Volume: 9, P: 1-11
Islet autoantibodies as precision diagnostic tools to characterize heterogeneity in type 1 diabetes: a systematic review

Felton et al. conduct a systematic review to determine the utility of islet autoantibodies as biomarkers of type 1 diabetes heterogeneity. They find that islet autoantibodies are most likely to be useful for patient stratification prior to clinical diagnosis.

Jamie L. Felton
Maria J. Redondo
Paul W. Franks
ResearchOpen Access06 Apr 2024
Communications Medicine

Volume: 4, P: 1-18
Tenomodulin knockout mice exhibit worse late healing outcomes with augmented trauma-induced heterotopic ossification of Achilles tendon

Manuel Delgado Caceres
Katharina Angerpointner
Denitsa Docheva
ResearchOpen Access05 Nov 2021
Cell Death & Disease

Volume: 12, P: 1-13
A new quinoline-based chemical probe inhibits the autophagy-related cysteine protease ATG4B

D. Bosc
L. Vezenkov
R. N. Young
ResearchOpen Access03 Aug 2018
Scientific Reports

Volume: 8, P: 1-17
Cardiomyocyte death: mechanisms and translational implications

M Chiong
Z V Wang
S Lavandero
ReviewsOpen Access22 Dec 2011
Cell Death & Disease

Volume: 2, P: e244
Toughening of Dental Composites with Thiourethane-Modified Filler Interfaces

Ana P. Fugolin
Daniel Sundfeld
Carmem S. Pfeifer
ResearchOpen Access19 Feb 2019
Scientific Reports

Volume: 9, P: 1-9
Magnetized plasma implosion in a snail target driven by a moderate-intensity laser pulse

T. Pisarczyk
S. Yu Gus’kov
Ph. Korneev
ResearchOpen Access17 Dec 2018
Scientific Reports

Volume: 8, P: 1-11
Nutritional depletion and its relationship to respiratory impairment in patients with chronic respiratory failure due to COPD or restrictive thoracic diseases

S Budweiser
K Meyer
M Pfeifer
Research07 Mar 2007
European Journal of Clinical Nutrition

Volume: 62, P: 436-443
Overexpression of Cx43 in cells of the myocardial scar: Correction of post-infarct arrhythmias through heterotypic cell-cell coupling

Wilhelm Roell
Alexandra M. Klein
Bernd K. Fleischmann
ResearchOpen Access08 May 2018
Scientific Reports

Volume: 8, P: 1-14
BRCAI and BRCA2 Mutation Analysis in At-risk African-American Families: Results and Implications

L Baumhach
L Gavol
J Fernando Arena
Research Highlights01 Jan 2000
Genetics in Medicine

Volume: 2, P: 75
Dietary acrylamide intake and risk of breast cancer in the UK women's cohort

V J Burley
D C Greenwood
J E Cade
ResearchOpen Access19 Oct 2010
British Journal of Cancer

Volume: 103, P: 1749-1754
Utility and precision evidence of technology in the treatment of type 1 diabetes: a systematic review

Jacobsen, Sherr et al. evaluate the utility of novel technologies in the treatment of type 1 diabetes. Their systematic review finds technologies such as continuous glucose monitoring, insulin pumps, and decision support tools improve important measures (e.g., HbA1c, time in range, quality of life) allowing precision-directed uptake of technology.

Laura M. Jacobsen
Jennifer L. Sherr
Paul W. Franks
ResearchOpen Access05 Oct 2023
Communications Medicine

Volume: 3, P: 1-24
Precision stratification of prognostic risk factors associated with outcomes in gestational diabetes mellitus: a systematic review

Semnani-Azad et al. review the evidence on prognostic factors that predict cardiovascular disease and type 2 diabetes for women, and cardiometabolic profile in offspring subsequent to gestational diabetes. The evidence was of low quality, but some maternal characteristics were predictive of unfavourable outcomes in women and their offspring.

Zhila Semnani-Azad
Romy Gaillard
Wei Perng
ResearchOpen Access12 Jan 2024
Communications Medicine

Volume: 4, P: 1-14
Prenatal ultrasound and the risk of childhood brain tumour and its subtypes

K Stålberg
B Haglund
H Kieler
ResearchOpen Access18 Mar 2008
British Journal of Cancer

Volume: 98, P: 1285-1287
The cytoplasmic part of L1-CAM controls growth and gene expression in human tumors that is reversed by therapeutic antibodies

D Gast
S Riedle
P Altevogt
Research22 Oct 2007
Oncogene

Volume: 27, P: 1281-1289
Precision subclassification of type 2 diabetes: a systematic review

Misra, Wagner et al. systematically review if strategies to subclassify type 2 diabetes (T2D) are associated with high quality evidence and patient outcomes. Cluster-based stratification yields T2D subtypes that associate with outcomes, suggesting subclassification could have future clinical use.

Shivani Misra
Robert Wagner
Miriam S. Udler
ResearchOpen Access05 Oct 2023
Communications Medicine

Volume: 3, P: 1-19
Luminal cytokeratin expression profiles of breast papillomas and papillary carcinomas and the utility of a cytokeratin 5/p63/cytokeratin 8/18 antibody cocktail in their distinction

Emily S Reisenbichler
Nicole N Balmer
Omar Hameed
Research12 Nov 2010
Modern Pathology

Volume: 24, P: 185-193
Molecular diagnosis of Ewing sarcoma/primitive neuroectodermal tumor in routinely processed tissue: a comparison of two FISH strategies and RT-PCR in malignant round cell tumors

Robert S Bridge
Veena Rajaram
Arie Perry
Research02 Sept 2005
Modern Pathology

Volume: 19, P: 1-8
Refining the diagnosis of gestational diabetes mellitus: a systematic review and meta-analysis

Francis et al. perform a systematic review and meta-analysis to evaluate studies comparing perinatal outcomes among individuals with gestational diabetes mellitus (GDM). Their review and post hoc analysis find that maternal preconception weight and non-glucose-dependent biochemical markers could be a precision diagnostic approach to reducing variability in clinical outcomes following treatment.

Ellen C. Francis
Camille E. Powe
Paul W. Franks
ResearchOpen Access18 Dec 2023
Communications Medicine

Volume: 3, P: 1-17
Impact of individual and environmental factors on dietary or lifestyle interventions to prevent type 2 diabetes development: a systematic review

Bodhini et al. systematically review the evidence on sociodemographic, clinical, behavioral, and molecular factors that modify the effect of interventions for type 2 diabetes prevention. The certainty of evidence that such factors modify the effectiveness of lifestyle and behavioral interventions is low to very low.

Dhanasekaran Bodhini
Robert W. Morton
Ruth J. F. Loos
ResearchOpen Access05 Oct 2023
Communications Medicine

Volume: 3, P: 1-17
Transposable elements shape the evolution of mammalian development

In this Review, Senft and Macfarlan discuss the diverse ways by which transposable elements (TEs) contribute to mammalian development and evolution, including direct contributions through TE-derived regulatory elements, RNAs and proteins, as well as indirect effects through the evolution of a TE repression system, the Krüppel-associated box zinc finger proteins (KRAB-ZFPs).

Anna D. Senft
Todd S. Macfarlan
Reviews05 Aug 2021
Nature Reviews Genetics

Volume: 22, P: 691-711
Annexin A1 Deficiency does not Affect Myofiber Repair but Delays Regeneration of Injured Muscles

Evgenia Leikina
Aurelia Defour
Jyoti K. Jaiswal
ResearchOpen Access15 Dec 2015
Scientific Reports

Volume: 5, P: 1-12
Disease-modifying therapies and features linked to treatment response in type 1 diabetes prevention: a systematic review

Felton et al. conducted a systematic review to evaluate studies testing disease-modifying therapies and features linked to treatment response for type 1 diabetes prevention. While the quality of prevention and intervention trials is found to be high, precision analyses on factors associated with treatment response are of poorer quality.

Jamie L. Felton
Kurt J. Griffin
Paul W. Franks
ResearchOpen Access05 Oct 2023
Communications Medicine

Volume: 3, P: 1-16
The use of precision diagnostics for monogenic diabetes: a systematic review and expert opinion

Murphy, Kevin, Pollin et al. perform a systematic review of the evidence on the criteria used to select individuals with diabetes for genetic testing and of the evidence for the optimal methods for variant detection in genes involved in monogenic diabetes. Based on the findings the authors make recommendations and highlight challenges for the field.

Rinki Murphy
Kevin Colclough
Anna L. Gloyn
ResearchOpen Access05 Oct 2023
Communications Medicine

Volume: 3, P: 1-24
Specific, targetable interactions with the microenvironment influence imatinib-resistant chronic myeloid leukemia

Rahul Kumar
Raquel S. Pereira
Daniela S. Krause
ResearchOpen Access21 May 2020
Leukemia

Volume: 34, P: 2087-2101
Characterization of a reference material for BCR-ABL (M-BCR) mRNA quantitation by real-time amplification assays: towards new standards for gene expression measurements

J Saldanha
M Silvy
J Gabert
Research03 May 2007
Leukemia

Volume: 21, P: 1481-1487
Cardiac Depression in Pigs after Multiple Trauma – Characterization of Posttraumatic Structural and Functional Alterations

M. Kalbitz
S. Schwarz
K. Almahmoud
ResearchOpen Access19 Dec 2017
Scientific Reports

Volume: 7, P: 1-13

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