Nature Search

Autocrine interferon poisoning mediates ADAR1-dependent synthetic lethality in BRCA1/2-mutant cancers

The RNA editing enzyme ADAR1 blocks interferon responses triggered by cytosolic RNA sensors, and has been proposed as a potential target in immuno-oncology. Here, the authors report that BRCA1/2 and ADAR1 are synthetic lethal, showing that ADAR1 depletion in BRCA1-mutant cells causes autocrine interferon poisoning

Roman M. Chabanon
Liudmila Shcherbakova
Sophie Postel-Vinay
ResearchOpen Access29 Jul 2025
Nature Communications

Volume: 16, P: 1-19
Increased serum GHBP levels in obese pubertal children and adolescents: relationship to body composition, leptin and indicators of metabolic disturbances

J Kratzsch
B Dehmel
M Wabitsch
Research01 Dec 1997
International Journal of Obesity

Volume: 21, P: 1130-1136
MAT2A inhibitor AG-270/S095033 in patients with advanced malignancies: a phase I trial

AG-270 inhibited the activity of MAT2A and reduced plasma concentrations of SAM by up to 70% in patients with advanced solid tumors. Partial responses were observed in two patients and disease stabilization for ≥4 months was seen in five patients.

Mrinal Gounder
Melissa Johnson
Josep Tabernero
ResearchOpen Access06 Jan 2025
Nature Communications

Volume: 16, P: 1-11
The potential of exploiting DNA-repair defects for optimizing lung cancer treatment

DNA repair as a therapeutic target has received considerable attention in the treatment of non-small-cell lung cancer (NSCLC). In this Review, Postel-Vinay et al. discuss how optimizing treatment of NSCLC according to DNA-repair biomarkers, such as ERCC1, BRCA1 or RRM1, may aid clinical decision making and improve the outcome of patients with NSCLC.

Sophie Postel-Vinay
Elsa Vanhecke
Jean-Charles Soria
Reviews14 Feb 2012
Nature Reviews Clinical Oncology

Volume: 9, P: 144-155
145 GROWTH HORMONE RECEPTORS AND THE ONSET OF HYPERINSULINEMIA IN THE OBESE ZUCKER RAT

M-C Postel-Vinay
P Durand
M Lavau
Research01 Jun 1985
Pediatric Research

Volume: 19, P: 627
A phase 1 trial of imatinib, bevacizumab, and metronomic cyclophosphamide in advanced colorectal cancer

R K Kelley
J Hwang
E K Bergsland
ResearchOpen Access10 Sept 2013
British Journal of Cancer

Volume: 109, P: 1725-1734
MOLECULAR ANALYSIS OF TWO FAMILIES WITH LARON SYNDROME AND POSITIVE GROWTH HORMONE BINDING PROTEIN

P Duquesnov
M-L Sobrier
S Amselem
Research01 May 1993
Pediatric Research

Volume: 33, P: S60
142 SUPERFICIAL CHRONIC GASTRITIS IN IDDM CHILDREN

G L de Angelis
M Vanelli
G Giovannelli
Research01 Jun 1985
Pediatric Research

Volume: 19, P: 627
141 PRL, PLASMA RENIN ACTIVITY AND ALDOSTERONE RESPONSE TO DOMPERIDONE IN IDDM CHILDREN

N Vanelli
C Terzi
G Giovannelli
Research01 Jun 1985
Pediatric Research

Volume: 19, P: 627
143 B-EP RESPONSE TO TRH/LHRH IN DIABETIC CHILDREN (IDDM)

S Bernasconi
F Petraglia
A R Genazzani
Research01 Jun 1985
Pediatric Research

Volume: 19, P: 627
Screening for congenital hypothyroidism - results from a pilot study in Stockholm

A Larsson
G Bodegård
P Olin
Research01 Oct 1979
Pediatric Research

Volume: 13, P: 1189
STRUCTURE-FUNCTION RELATIONSHIPS IN THE HUMAN GROWTH HORMONE MOLECULE: IMPORTANCE OF MOLECULAR CONFORMATION IN RADIORECEPTOR ASSAY AND RADIOIMMUNOASSAY ACTIVITY

M L Aubert
T A Bewley
S L Kaplan
Research01 Aug 1975
Pediatric Research

Volume: 9, P: 680
Binding properties of androgen receptors in genital skin fibroblasts of a patient with 5α-reductase deficiency

M Maes
C Sultan
C J Migeon
Research01 Oct 1979
Pediatric Research

Volume: 13, P: 1189
Kinetics of somatomedin C/insulin-like growth factor-I(SMC) response to hGH in GH deficient children

S L Blethen
V V Weldon
Research01 Dec 1981
Pediatric Research

Volume: 15, P: 1541
Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma

Olivier Delattre and colleagues report a genome-wide association study of Ewing sarcoma. They identify common variants near TARDBP and EGR2 influencing susceptibility to this rare pediatric tumor.

Sophie Postel-Vinay
Amélie S Véron
Olivier Delattre
Research12 Feb 2012
Nature Genetics

Volume: 44, P: 323-327
Human Fetal Adrenal Cell Responses to ACTH and Pituitary Extracts

O C Green
R Silkiss
R B Jaffe
Research01 Dec 1981
Pediatric Research

Volume: 15, P: 1543
XO/XY MOSAICISM: SHORT STATURE AND RESPONSE TO GROWTH HORMONE (GH) TREATMENT

B L Silverman
Research01 May 1993
Pediatric Research

Volume: 33, P: S60
SPECTRUM OF GROWTH HORMONE RECEPTOR MUTATIONS AND ASSOCIATED HAPLOTYPES IN LARON SYNDROME

S Amselem
F Dastol
M Goossens
Research01 May 1993
Pediatric Research

Volume: 33, P: S60
THE EFFECT OF AGE ON BONE MATURATION IN GROWTH HORMONE (GH) TREATED BOYS

A Zadik
A Zuhg
A Kowarski
Research01 May 1993
Pediatric Research

Volume: 33, P: S60
PRETREATMENT WITH SMS 201–995 POTENTIATES GRF RESPONSE IN SHORT CHILDREN

Z Dickerman
H J Guyda
G S Tannenbaum
Research01 May 1993
Pediatric Research

Volume: 33, P: S60
Acute and chronic somatomedin-C response to growth hormone: evaluation of correlation with age and growth rate

R Rosenfeld
S Kemp
R Hintz
Research01 Dec 1981
Pediatric Research

Volume: 15, P: 1553
Growth of Snell dwarfmice with hGH, insulin and peptide fractions containing SM-activity

S C Van Buul
J L Van Den Brande
P Van De Klundert
Research01 Nov 1978
Pediatric Research

Volume: 12, P: 1087
Autoimmune polyendocrinopathy-candidosis syndrome (APECS): Clinical variation, inheritance and HLA association in 40 Finnish patients

J Perheentupa
A Tiilikainen
M L Lokki
Research01 Nov 1978
Pediatric Research

Volume: 12, P: 1087
Mechanisms of Sertoli Cell Damage in Experimental Cryptorchidism in the Rat

M Ritzén
Research01 Nov 1978
Pediatric Research

Volume: 12, P: 1087
Somatomedin (SM-A) and the carrier proteins: regulation by growth hormone

L Fryklund
K Hall
S Castensson
Research01 Nov 1978
Pediatric Research

Volume: 12, P: 1087
Down-regulation of gonadotropin release by the ovine fetal pituitary gland by the superagonist D-Trp⁶pro⁹NET-LRF

S J Clark
D M Styne
M M Grumbach
Research01 Dec 1981
Pediatric Research

Volume: 15, P: 1543
Cell mediated immunity to pituitary extracts in hypopituitarism

D O Sobel
J P Gutai
P Fireman
Research01 Dec 1981
Pediatric Research

Volume: 15, P: 1541
LOW PROCONVERTIN (FACTOR VII) AND IMPAIRED BLOOD CLOTTING DUE TO GROWTH HORMONE DEFICIENCY IN THE RAT

L S Sävendahl
K G Engström
K Grankvist
Research01 May 1993
Pediatric Research

Volume: 33, P: S63
Ontogeny of Growth Factor Receptors in the Human Placenta

Cheri L Deal
Harvey J Guyda
Barry I Posner
Research01 Oct 1982
Pediatric Research

Volume: 16, P: 820-826
Relationships between IGF-I and age, gender, body mass, fat distribution, metabolic and hormonal variables in obese patients

M Maccario
J Ramunni
E Ghigo
Research26 Jun 1999
International Journal of Obesity

Volume: 23, P: 612-618
A high-throughput screen identifies PARP1/2 inhibitors as a potential therapy for ERCC1-deficient non-small cell lung cancer

S Postel-Vinay
I Bajrami
A Ashworth
Research12 Aug 2013
Oncogene

Volume: 32, P: 5377-5387
The Intracellular Domain of the Rabbit Prolactin Receptor is Able to Promote the Secretion of a Passenger Protein via an Unusual Secretory Pathway in Lepidopteran Cells

Laurence Garnier
Claire Cahoreau
Martine Cérutti
Research01 Oct 1995
Bio/Technology

Volume: 13, P: 1101-1104
Physiopathology of prolactin secretion in obesity

PG Kopelman
Research24 Jul 2000
International Journal of Obesity

Volume: 24, P: S104-S108
Clinical benefit in Phase-I trials of novel molecularly targeted agents: does dose matter?

S Postel-Vinay
H-T Arkenau
S Kaye
ResearchOpen Access28 Apr 2009
British Journal of Cancer

Volume: 100, P: 1373-1378
Imatinib-induced ophthalmological side-effects in GIST patients are associated with the variations of EGFR, SLC22A1, SLC22A5 and ABCB1

H-B Qiu
W Zhuang
X-D Wang
ResearchOpen Access01 Aug 2017
The Pharmacogenomics Journal

Volume: 18, P: 460-466
Cell-to-cell heterogeneity of EWSR1-FLI1 activity determines proliferation/migration choices in Ewing sarcoma cells

G-A Franzetti
K Laud-Duval
O Delattre
ResearchOpen Access30 Jan 2017
Oncogene

Volume: 36, P: 3505-3514
EWS-FLI1 perturbs MRTFB/YAP-1/TEAD target gene regulation inhibiting cytoskeletal autoregulatory feedback in Ewing sarcoma

A M Katschnig
M O Kauer
H Kovar
ResearchOpen Access03 Jul 2017
Oncogene

Volume: 36, P: 5995-6005
A first-in-human phase I study to determine the maximum tolerated dose of the oral Src/ABL inhibitor AZD0424

Victoria K Woodcock
Sally Clive
Mark R Middleton
ResearchOpen Access13 Feb 2018
British Journal of Cancer

Volume: 118, P: 770-776
Phase I study of saracatinib (AZD0530) in combination with paclitaxel and/or carboplatin in patients with solid tumours

S Kaye
S Aamdal
E Boven
ResearchOpen Access24 Apr 2012
British Journal of Cancer

Volume: 106, P: 1728-1734
First-in-human Phase 1 open label study of the BET inhibitor ODM-207 in patients with selected solid tumours

Malaka Ameratunga
Irene Braña
Johann S de Bono
ResearchOpen Access29 Sept 2020
British Journal of Cancer

Volume: 123, P: 1730-1736
Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness

Harriett Holme
Aditi Gulati
Christopher J. Lord
ResearchOpen Access13 Jul 2018
Scientific Reports

Volume: 8, P: 1-9
Author Correction: Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness

Harriett Holme
Aditi Gulati
Christopher J. Lord
Amendments and CorrectionsOpen Access21 Aug 2018
Scientific Reports

Volume: 8, P: 1
The insulin-like growth factor-I receptor inhibitor figitumumab (CP-751,871) in combination with docetaxel in patients with advanced solid tumours: results of a phase Ib dose-escalation, open-label study

L R Molife
P C Fong
J S de Bono
ResearchOpen Access13 Jul 2010
British Journal of Cancer

Volume: 103, P: 332-339

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