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JWST/NIRSpec observations of the 49 Ceti debris disk reveal spatially resolved, fluorescently excited CO emission, indicating a secondary origin of the gas in debris disks (that is, from the collision of volatile-rich bodies).

Native state proteomics of PV interneurons revealed unique molecular features of high translational and metabolic activity, and enrichment of Alzheimer’s risk genes. Early amyloid pathology exerted unique effects on mitochondria, mTOR signaling and neurotransmission in PV neurons.

Zhu et al. show that cAMP-dependent PKA phosphorylates Bora, enabling Aurora A binding and Plk1 activation. This modification ensures timely mitotic entry, unveiling a previously unrecognized interface between PKA signaling and cell cycle regulation.

Efficient voltage-controlled regulation of water and ion transport was achieved in stable Zr₄-Ti₃C₂T_x membranes. Under negative voltage, water diffusion was enhanced while ion transport was suppressed. This provides a promising strategy to overcome the intrinsic permeability– selectivity trade-off.

A reverse osmosis membrane synthesized via a vapour–solid interfacial reaction demonstrates high permselectivity and exhibits good anti-fouling performance, providing a simple and effective methylation approach to enhancing membrane-fouling resistance.

Creating precise morphogen gradients for tissue engineering is challenging. Here the authors present mechanically tunable DNA hydrogel-based microbeads for light-controlled morphogen release in retinal organoids for better tissue mimicry.

The RNA binding protein MUSASHI-2 (MSI2) is a potential therapeutic target for acute myeloid leukemia. Here the authors identify a small molecule inhibitor of MSI2 and characterize its effects in a murine leukemia model.

This Bayesian statistical method uses timeseries microbiome data to infer interaction modules and is tested using a faecal transplant experiment in mice.

Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) is a life-threatening condition different from self-limiting nature of Epstein-Barr virus-induced infectious mononucleosis (IM). Here the authors identify IDO1⁺ monocytes and L-kynurenine as biomarkers for HLH by comparing single cell sequencing data of HLH patients with IM and healthy volunteers as the controls.

Electronic health records are a rich source of clinical data but identifying associations with outcomes is complex. Here, the authors propose a modelling framework ‘InfEHR’ that identifies patient trajectories in electronic health records and generates a likelihood for clinical phenotypes.

Lymphangioleiomyomatosis (LAM) is a rare disease in women where TSC2 deficient mTOR signalling aberrant LAM cells and fibroblasts form nodules causing lung cysts and respiratory failure. Here the authors examine how mTOR dependent IL-6 causes senescence in alveolar type 2 cells which may result in impaired lung repair.

A comprehensive benchmarking of 19 histopathology foundation models finds that a vision-language foundation model outperforms vision-only models.

Cell division requires strict control of DNA replication and centrosome duplication. Here, the authors reveal that DNA replication machinery transmits dual signals to control proper timing of centrosome duplication for genome stability

Although ice plays a crucial role in shaping our ecosphere, its microstructures formed by freezing water remain unclear. Here, the authors employ cryogenic liquid-cell TEM to gain atomic-level insights into ice defects frozen from liquid water.

Inhibition of the protein arginine methyltransferase PRMT5 has been suggested as a promising therapy for lymphoma. Here, the authors show that TP53 loss of function and MUSASHI-2 (MSI2) expression are biomarkers of resistance to PRMT5-targeted therapy in B-cell lymphoma. Moreover, combining PRMT5 inhibition with MSI2 or BCL-2 inhibitors blocks the translation of key drivers of lymphoma, c-MYC and BCL-2, inhibiting cell growth.

An organic photoredox catalyst system efficiently reduces C–F bonds, generating carbon-centred radicals for hydrodefluorination and cross-coupling reactions, enabling the general use of organofluorines as synthons and breaking down environmentally damaging forever chemicals.

Solar power desalination is a promising technology for clean water production in off-grid locations. Now a time-variant version of this technology overcomes the solar power intermittency that such desalination plants suffer from, hence reducing the need for costly batteries

Nociceptin is an opioid peptide regulating important brain functions, including motivation and 2stress responses. Here, the authors develop and validate a genetically encoded sensor as a tool for high-resolution detection of endogenous nociceptin in living animals.

The genetic architecture underlying Sjögren’s syndrome is not fully understood. Here, the authors perform a genome-wide association study to identify 10 new genetic risk regions, implicating genes involved in immune and salivary gland function.

Attosecond core-level spectroscopy is used to probe the ultrafast molecular dynamics of furan at the carbon K-edge, demonstrating its ability to simultaneously probe electronic and vibrational dynamics.

Aside from their pollination function, pollinators consume and are consumed by other members of ecological communities; these relationships could explain the controversial effects of pollinators on ecological networks. Here the authors show that when mutualists such as pollinators are introduced into food webs, they increase ecosystem biodiversity, stability, and function.

Dual cyclin A/B RxL inhibitors selectively kill small cell lung cancer cells and other cancer cells with high E2F activity.

The limited proliferative capacity of erythroid precursors complicates the production of red blood cells for clinical purposes in vitro. Here, the authors show that erythroid proliferative capacity can be vastly increased by BMI1 overexpression, which regulates erythroid self-renewal through both gene repression and activation.

TAAR1 has a rigid consensus binding motif that binds to endogenous trace amine stimuli as well as two extended binding pockets that accommodate diverse chemotypes.

Orthogonal acute inducible degradation cell lines are used to delineate the mechanisms of how extrusive cohesin, cohesive cohesin and condensin interact to remodel chromosome architecture from interphase to mitosis.

Potable reuse provides a reliable and sustainable option to drinking-water supply. However, its implementation is hindered by perceptions of potential health risks. Here, comparing potable reuse water with tap water, the authors show a lower level of cytotoxicity in reuse water.

CO₂ reduction (CO₂R) to C₂₊ alcohols has low selectivity and current density due to competing C₂+ pathways that produce ethylene. Defect-rich Pr–Cu oxide heterointerfaces are developed to induce asymmetric carbon–carbon coupling and selective hydrodeoxygenation of CO₂R intermediates, accelerating the production of C₂₊ alcohols.

Preventing endosomal damage sensing or using lipids that create reparable endosomal holes reduces inflammation caused by RNA–lipid nanoparticles while enabling high RNA expression.

Microporous polymer membranes are promising for gas separation but are prone to aging, reducing performance. Here the authors use a defluorination-induced crosslinking method on aryl-ether-free aromatic polymers, forming a membrane for CO₂ separation.

CCR5 is a co-receptor for many transmitted HIV strains. Here, the authors show that biweekly injection of the CCR5-specific antibody Leronlimab protects rhesus macaques against infection following repeated intrarectal challenges of a CCR5-tropic SHIV.

Gravity waves are observed in Venus atmosphere, but their characteristics are not well-known. Here, the authors show spontaneous generation of gravity waves from the thermal tides in the Venus atmosphere as small-scale gravity waves are resolved in high-resolution general circulation model.

This study reveals trade-offs in freshwater savings, cost and capacity shortfalls from deploying treated brackish water for wet thermoelectric cooling, as well as its cost-effectiveness, relative to dry cooling retrofit, in saving freshwater.

This report identifies Cdk1's phosphorylation of BRCA1 as an important regulator of BRCA1's DNA repair function. Cdk1 inhibition renders cancer cells sensitive to PARP inhibition, and the combination treatment can inhibit tumor growth in vivo, expanding the potential application of PARP inhibitors beyond BRCA1-deficient tumors.