Nature Search

Distinct cell state ecosystems for nodular lymphocyte-predominant Hodgkin lymphoma

Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare cancer. Here, the authors develop a NLPHL specific model to identify 34 distinct cell states across 14 cell types that co-occur within 3 lymphocyte predominant ecotypes (LPEs) for 171 cases.

Ajay Subramanian
Shengqin Su
Michael Sargent Binkley
ResearchOpen Access26 Sept 2025
Nature Communications

Volume: 16, P: 1-16
Molecular-resolution imaging of ice crystallized from liquid water by cryogenic liquid-cell TEM

Although ice plays a crucial role in shaping our ecosphere, its microstructures formed by freezing water remain unclear. Here, the authors employ cryogenic liquid-cell TEM to gain atomic-level insights into ice defects frozen from liquid water.

Jingshan S. Du
Suvo Banik
James J. De Yoreo
ResearchOpen Access25 Sept 2025
Nature Communications

Volume: 16, P: 1-12
ALS/FTD-linked TBK1 deficiency in microglia induces an aged-like microglial signature and drives social recognition deficits in mice

TBK1 mutations are linked to Amyotrophic Lateral Sclerosis (ALS) and Fronto-temporal dementia (FTD), but their cell-type specific disease contributions are unclear. Here, the authors show that Tbk1 deletion from mouse microglia shifts them to an aged-like phenotype and causes social recognition deficits.

Isadora Lenoel
Matthieu Ribon
Christian S. Lobsiger
ResearchOpen Access26 Aug 2025
Nature Communications

Volume: 16, P: 1-20
Relative Efficiencies of Indian Languages

B. S. RAMAKRISHNA
K. K. NAIR
R. SUBRAMANIAN
Research25 Feb 1961
Nature

Volume: 189, P: 614-617
‘Missing image’ in gravitational lens systems?

D. Narasimha
K. Subramanian
S. M. Chitre
Research01 May 1986
Nature

Volume: 321, P: 45-46
Designing lipid nanoparticles using a transformer-based neural network

Preventing endosomal damage sensing or using lipids that create reparable endosomal holes reduces inflammation caused by RNA–lipid nanoparticles while enabling high RNA expression.

Alvin Chan
Ameya R. Kirtane
Giovanni Traverso
ResearchOpen Access15 Aug 2025
Nature Nanotechnology

P: 1-11
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Sarcoma microenvironment cell states and ecosystems are associated with prognosis and predict response to immunotherapy

Subramanian et al. use the EcoTyper machine-learning framework to characterize the tumor, immune and stromal cell states and ecosystems that comprise sarcomas.

Ajay Subramanian
Neda Nemat-Gorgani
Everett J. Moding
Research01 Mar 2024
Nature Cancer

Volume: 5, P: 642-658
A Factor promoting Dissociation of Escherichia coli Ribosomes

S. H. MIALL
T. KATO
T. TAMAOKI
Research13 Jun 1970
Nature

Volume: 226, P: 1050-1052
Sustainable machining and optimization of machining parameters utilizing different dielectrics in EDM machining of Waspaloy

Putta Priyanka
V. Jayakumar
S. M. Muthu
ResearchOpen Access26 Sept 2025
Scientific Reports

Volume: 15, P: 1-22
Purification and Properties of Initiation Factor F₃

STEVEN SABOL
MARIA ANTONIA G. SILLERO
SEVERO OCHOA
Research26 Dec 1970
Nature

Volume: 228, P: 1269-1273
Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease

The immune-checkpoint molecule TIM-3 regulates microglial homeostasis, and its microglial-specific deletion reduced cognitive impairment in a mouse model of Alzheimer’s disease.

Kimitoshi Kimura
Ayshwarya Subramanian
Vijay K. Kuchroo
Research09 Apr 2025
Nature

Volume: 641, P: 718-731
Dendroclimatological implications of isotope coherence in trees from Kashmir Valley, India

R. Ramesh
S. K. Bhattacharya
K. Gopalan
Research01 Oct 1985
Nature

Volume: 317, P: 802-804
Tumor cell-adipocyte gap junctions activate lipolysis and contribute to breast tumorigenesis

Breast cancer cells interact with neighbouring adipocytes, but the mechanisms are not fully understood. Here, the authors show that triple-negative breast cancer (TNBC) cells transfer cAMP through gap junctions, activating lipolysis in tumour-associated adipocytes to promote TNBC growth.

Jeremy Williams
Roman Camarda
Andrei Goga
ResearchOpen Access20 Aug 2025
Nature Communications

Volume: 16, P: 1-17
Control of copper valence in Bi₂Sr_2–xCaCu₂ O₈

A. K. CHEETHAM
A. M. CHIPPINDALE
S. J. HIBBLE
Research05 May 1988
Nature

Volume: 333, P: 21
British Normal Threshold of Hearing

L. S. WHITTLE
D. W. ROBINSON
Research25 Feb 1961
Nature

Volume: 189, P: 617-618
Genetic Marker of the γA2 Subgroup of γA Immunoglobulins

H. G. KUNKEL
W. K. SMITH
S. D. LITWIN
Research20 Sept 1969
Nature

Volume: 223, P: 1247-1248
Inhibition of haemoglobin S gelation and water structural effects

S. SUBRAMANIAN
Research01 Jul 1981
Nature

Volume: 292, P: 274
Meta-analysis of effects of exclusive breastfeeding on infant gut microbiota across populations

Studies on the effects of breastfeeding on the infant gut microbiota have provided inconsistent results. Here, Ho et al. perform a meta-analysis of seven studies across different populations, supporting that exclusive breastfeeding is associated with short-term and long-term alterations in the infant gut microbiota.

Nhan T. Ho
Fan Li
Louise Kuhn
ResearchOpen Access09 Oct 2018
Nature Communications

Volume: 9, P: 1-13
Oral dosing of the nucleoside analog obeldesivir is efficacious against RSV infection in African green monkeys

In this work, authors show that the nucleoside prodrug obeldesivir has potent antiviral activity across respiratory syncytial virus (RSV) clinical isolates with a high resistance barrier. Once-daily obeldesivir treatment was efficacious against RSV in a non-human primate model.

Jared Pitts
J. Lizbeth Reyes Zamora
John P. Bilello
ResearchOpen Access11 Jul 2025
Nature Communications

Volume: 16, P: 1-12
Seasonal variability and geochemical significance of organic matter in the River Ganges, Bangladesh

V. Ittekkot
S. Safiullah
R. Seifert
Research01 Oct 1985
Nature

Volume: 317, P: 800-802
ST2/IL-33 axis blockade inhibits regulatory T cell cytotoxicity towards CD8 T cells in the leukemic niche

Therapeutic checkpoint for acute myeloid leukemia requires further investigations. The authors here identify ST2⁺ Treg cells facilitate AML growth by inducing CD8⁺ T cell depletion and exhaustion, while targeting ST2 by antibodies depletes ST2⁺ Treg cells and improves AML prognosis.

Hua Jiang
Denggang Fu
Sophie Paczesny
ResearchOpen Access21 Jul 2025
Nature Communications

Volume: 16, P: 1-26
Preimplantation single cell analyses of dystrophin gene deletions using whole genome amplification

Kristleifur Kristjansson
Samuel S. Chong
Mark R. Hughes
Research01 Jan 1994
Nature Genetics

Volume: 6, P: 19-23
Superconductivity and microwave absorption

T.-S. LIN
L. G. SOBOTKA
W. FRONCISZ
Research05 May 1988
Nature

Volume: 333, P: 21-22
Rapid polymer transport in concentrated solutions through the formation of ordered structures

B. N. Preston
T. C. Laurent
G. J. Checkley
Research09 Oct 1980
Nature

Volume: 287, P: 499-503
Nucleotide sequence of the origin of replication in bacteriophage ΦX174 RF DNA

S. A. Langeveld
A. D. M. van Mansfeld
P. J. Weisbeek
Research02 Feb 1978
Nature

Volume: 271, P: 417-420
Single-cell and spatial transcriptomics of stricturing Crohn’s disease highlights a fibrosis-associated network

Single-cell and spatial transcriptomics analysis of stricturing Crohn’s disease highlights cellular heterogeneity in fibrotic tissue and identifies neighborhoods of fibroblasts and immune cells contributing to this severe disease complication.

Lingjia Kong
Sathish Subramanian
Ramnik J. Xavier
Research25 Jun 2025
Nature Genetics

Volume: 57, P: 1742-1753
Exploitable mechanisms of antibody and CAR mediated macrophage cytotoxicity

The mechanism of macrophage cytotoxicity against cancer cells requires further illustration. By employing CRISPR screening in CAR-macrophage and cancer cell co-culture system, the authors identify depletion of ATG9A on cancer cells sensitizes them to macrophage-mediated killing, which can be synergic with CSF1R inhibition in cancer treatment.

Tianyi Liu
Meng Zhang
Carl J. DeSelm
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-22
Early life microbial succession in the gut follows common patterns in humans across the globe

Here, the authors perform a global analysis of over 3000 infant gut samples revealing a universal pattern of microbial changes over the first 1.5 years, with declines in Bifidobacterium and increases in Faecalibacterium, providing a standard for early gut development.

Guilherme Fahur Bottino
Kevin S. Bonham
Vanja Klepac-Ceraj
ResearchOpen Access14 Jan 2025
Nature Communications

Volume: 16, P: 1-12
Ventral hippocampus neurons encode meal-related memory

The ability to encode and recall information about food is critical for survival. We reveal that ventral hippocampus projections to the lateral hypothalamus encode meal-related memories, and that disruption of this circuit promotes excessive eating.

Léa Décarie-Spain
Cindy Gu
Scott E. Kanoski
ResearchOpen Access11 Jun 2025
Nature Communications

Volume: 16, P: 1-16
Double burden of malnutrition among urban Bengalee adolescent boys in Midnapore, West Bengal, India

S Bisai
R Khongsdier
D Mahalanabis
ResearchOpen Access03 Apr 2012
Nature Precedings

P: 1
Double burden of malnutrition among urban Bengalee adolescent boys in Midnapore, West Bengal, India

S Bisai
R Khongsdier
D Mahalanabis
ResearchOpen Access03 Apr 2012
Nature Precedings

P: 1
Assessment Of Response To Heart Failure Therapy: Ventricular Volume Changes Versus Shape Changes

Srilakshmi Adhyapak
V.Rao Parachuri
ResearchOpen Access20 Dec 2011
Nature Precedings

P: 1
Multiple specific contacts between a mammalian transcription factor and its cognate promoters

David Gidoni
William S. Dynan
Robert Tjian
Research29 Nov 1984
Nature

Volume: 312, P: 409-413
Redefining IoT networks for improving energy and memory efficiency through compressive sensing paradigm

S. Balamurali
M. Kathirvelu
Ines Hilali Jaghdam
ResearchOpen Access26 Jul 2025
Scientific Reports

Volume: 15, P: 1-18
Books in brief

Barbara Kiser reviews five of the week's best science picks.

Barbara Kiser
Books & Arts12 Aug 2015
Nature

Volume: 524, P: 159
Fecal dysbiosis in infants with cystic fibrosis is associated with early linear growth failure

Most infants with cystic fibrosis have poor early linear growth in their first year despite nutritional supplementation and treatment. Intestinal dysbiosis in these infants is associated with low length, suggesting a path for intervention.

Hillary S. Hayden
Alexander Eng
Lucas R. Hoffman
Research20 Jan 2020
Nature Medicine

Volume: 26, P: 215-221
Salicylate and Increased Vascular Permeability

W. G. SPECTOR
D. A. WILLOUGHBY
Research15 Dec 1962
Nature

Volume: 196, P: 1104
Perovskite nickelates as bio-electronic interfaces

Functional materials that act as bio-sensing media when interfaced with complex bio-matter are attractive for health sciences and bio-engineering. Here, the authors report room temperature enzyme-mediated spontaneous hydrogen transfer between a perovskite quantum material and glucose reactions.

Hai-Tian Zhang
Fan Zuo
Shriram Ramanathan
ResearchOpen Access10 Apr 2019
Nature Communications

Volume: 10, P: 1-7
Divergent effects of central melanocortin signalling on fat and sucrose preference in humans

Hypothalamic melanocortin-4-receptors (MC4R) regulate food preference in rodents, but their role in humans is unclear. Here, the authors perform food preference and liking tests in humans with MC4R mutations and find that they prefer fatty food more, but sweet food less, than people without MC4R mutations.

Agatha A. van der Klaauw
Julia M. Keogh
I. Sadaf Farooqi
ResearchOpen Access04 Oct 2016
Nature Communications

Volume: 7, P: 1-5
Wind shear in a monsoon depression

C. R. V. RAMAN
Y. P. RAO
Z. E. SHEIKH
Research02 Nov 1978
Nature

Volume: 276, P: 51-53
Public awareness of cancer in Britain: a population-based survey of adults

K Robb
S Stubbings
J Wardle
ResearchOpen Access01 Oct 2009
Nature Precedings

P: 1
Effect of girls’ education on cancer awareness and screening in a natural experiment in Lesotho

Breast and cervical cancers are important causes of disability and premature death in Africa. The authors use an education policy in Lesotho as a natural experiment to show that girls’ schooling increases awareness of breast cancer, awareness of Pap smear, and screening with Pap smear.

Janny Liao
Ramaele Moshoeshoe
Jan-Walter De Neve
ResearchOpen Access20 Apr 2025
Nature Communications

Volume: 16, P: 1-9
Accurate determination of solvation free energies of neutral organic compounds from first principles

Theoretical estimations of solvation free energy by continuum solvation models are generally not accurate. Here the authors report a polarizable force field fitted entirely to first-principles calculations for the estimation of free energy of solvation of arbitrary molecules.

Leonid Pereyaslavets
Ganesh Kamath
Boris Fain
ResearchOpen Access20 Jan 2022
Nature Communications

Volume: 13, P: 1-7
Growth of superconducting single crystals in the Bi–Sr–Ca–Cu–O system from alkali chloride fluxes

L. F. Schneemeyer
R. B. van Dover
L. W. Rupp
Research31 Mar 1988
Nature

Volume: 332, P: 422-424
The accidental Nobel laureate, what we owe to our voices and the philosophy of touch: Books in Brief

Andrew Robinson reviews five of the week’s best science picks.

Andrew Robinson
Books & Arts17 Mar 2021
Nature

Volume: 591, P: 364
3-Å resolution structure of a protein with histone-like properties in prokaryotes

Isao Tanaka
Krzysztof Appelt
Keith S. Wilson
Research02 Aug 1984
Nature

Volume: 310, P: 376-381
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Author Correction: Mapping genetic diversity with the GenomeIndia project

Chandrika Bhattacharyya
Krithika Subramanian
Bratati Kahali
Amendments and Corrections08 May 2025
Nature Genetics

Volume: 57, P: 1563
Anemia prevalence in women of reproductive age in low- and middle-income countries between 2000 and 2018

Geospatial estimates of the prevalence of anemia in women of reproductive age across 82 low-income and middle-income countries reveals considerable heterogeneity and inequality at national and subnational levels, with few countries on track to meet the WHO Global Nutrition Targets by 2030.

Damaris Kinyoki
Aaron E. Osgood-Zimmerman
Simon I. Hay
ResearchOpen Access12 Oct 2021
Nature Medicine

Volume: 27, P: 1761-1782

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