Dextran sulfate sodium is a colitis inducer that stimulates a ROS–Src–IP6K2 signaling axis to generate 5-IP7, which sterically inhibits PI(4,5)P2 phosphatases to promote PI(4,5)P2-mediated E-cadherin endocytosis and epithelial junction breakdown.
- Hongyun Zhang
- Bobo Zhang
- Feng Rao