A triple-helical peptide, H-(Pro-Pro-Gly)10-OH (PPG10) forms complex with NaHeparin in aqueous NaCl at ionic strengths of 20 and 50 mM and at 15 °C. The triple helix of PPG10 in the resulting complex is appreciably stabilized and the melting temperature of the triple helix is considerably higher than without NaHeparin. Analyses of the scattering function of the complex indicate that the molecular shape is substantially different from that of the previously investigated complex, suggesting specific attractive interactions between PPG10 and NaHeparin.
- Saki Ishida
- Tasuku Yoshida
- Ken Terao