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Expression of tumor antigens within an oncolytic virus enhances the anti-tumor T cell response

Oncolytic viruses create an inflamed tumour microenvironment allowing T cells to respond to immune checkpoint blockade therapy more efficiently. Authors here show that in a hepatocellular carcinoma model, a dominant anti-viral rather than anti-tumour T cell response is elicited by an oncolytic vesicular stomatitis virus, unless the virus is designed to express tumour antigens, which restores therapeutic benefit.

Mason J. Webb
Thanich Sangsuwannukul
Richard Vile
ResearchOpen Access27 Jun 2024
Nature Communications

Volume: 15, P: 1-18
Precision targeting of β-catenin induces tumor reprogramming and immunity in hepatocellular cancers

Gain-of-function mutations in CTNNB1 (encoding for b-catenin) leading to deregulated Wnt/β-catenin signaling are frequently observed in patients with hepatocellular carcinoma (HCC). Here the authors show that inhibiting b-catenin with lipid nanoparticles encapsulating siRNA targeting CTNNB1 impairs tumor growth and promotes anti-tumor immunity in preclinical HCC models.

Brandon M. Lehrich
Evan R. Delgado
Satdarshan P. Monga
ResearchOpen Access30 May 2025
Nature Communications

Volume: 16, P: 1-26
Matrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic liver

Structural changes mediated by advanced glycation end-products enhance extracellular matrix viscoelasticity, and that viscoelasticity can promote cancer progression in vivo, independent of stiffness.

Weiguo Fan
Kolade Adebowale
Natalie J. Török
ResearchOpen Access31 Jan 2024
Nature

Volume: 626, P: 635-642
WNT–β-catenin signalling in hepatocellular carcinoma: from bench to clinical trials

WNT–β-catenin activation is common in hepatocellular carcinoma (HCC). In this Review, the authors summarize our understanding of the role of WNT–β-catenin activation in HCC — based on results from in vitro and in vivo models — and implications for precision treatment of HCC via targeting β-catenin.

Brandon M. Lehrich
Satdarshan P. Monga
Reviews09 Oct 2025
Nature Reviews Gastroenterology & Hepatology

P: 1-18
Hepatic stellate cells control liver zonation, size and functions via R-spondin 3

Hepatic stellate cells regulate hepatocyte functions via R-spondin 3.

Atsushi Sugimoto
Yoshinobu Saito
Robert F. Schwabe
ResearchOpen Access12 Mar 2025
Nature

Volume: 640, P: 752-761
Hepatic stellate cell stearoyl co-A desaturase activates leukotriene B4 receptor 2 - β-catenin cascade to promote liver tumorigenesis

Activated hepatic stellate cells (aHSC) promote hepatocellular carcinoma (HCC). Here the authors show that selective ablation of stearoyl CoA desaturase-2 in aHSC suppresses leukotriene B4 receptor 2-dependent nuclear β-catenin signaling, preventing liver tumorigenesis.

Sonal Sinha
Satoka Aizawa
Hidekazu Tsukamoto
ResearchOpen Access08 May 2023
Nature Communications

Volume: 14, P: 1-14
Precision models in hepatocellular carcinoma

In this Review, Lujambio and colleagues provide an overview of the use of in vitro and in vivo precision models for hepatocellular carcinoma, their strengths and limitations, and how they can be used to identify and test precision therapies and biomarkers.

Marina Barcena-Varela
Satdarshan P. Monga
Amaia Lujambio
Reviews11 Dec 2024
Nature Reviews Gastroenterology & Hepatology

Volume: 22, P: 191-205
A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance

E3 ligase subunit protein Fbxo48 interacts with phosphorylated Ampkα and mediates its proteasomal degradation. Interruption of the pAmpkα/Fbxo48 interaction by a small-molecule BC1618 promoted Ampkα activation and improved insulin sensitivity.

Yuan Liu
Michael J. Jurczak
Rama K. Mallampalli
Research25 Jan 2021
Nature Chemical Biology

Volume: 17, P: 298-306
Author Correction: Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis

Josepmaria Argemi
Maria U. Latasa
Ramon Bataller
Amendments and CorrectionsOpen Access10 Feb 2023
Nature Communications

Volume: 14, P: 1
Functional compensation precedes recovery of tissue mass following acute liver injury

The liver possesses the ability to regenerate following sudden injury. Here, the authors use single-cell RNA-sequencing and in situ transcriptional analyses to identify a new phase of liver regeneration in mice aimed at maintaining essential functions throughout the regenerative process.

Chad M. Walesky
Kellie E. Kolb
Wolfram Goessling
ResearchOpen Access19 Nov 2020
Nature Communications

Volume: 11, P: 1-12
Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis

Alcoholic hepatitis, a common cause of liver failure, lacks effective treatment. Here, the authors show altered hepatic HNF4a isoform expression and hypermethylation of its target genes in patients. HNF4a dysregulation is improved in vitro by TGFb or PPARg modulation suggesting potential therapeutic avenues.

Josepmaria Argemi
Maria U. Latasa
Ramon Bataller
ResearchOpen Access16 Jul 2019
Nature Communications

Volume: 10, P: 1-19
Updates on hepatic homeostasis and the many tiers of hepatobiliary repair

Deciphering the complex circuitry of liver homeostasis and repair is required to improve regenerative therapies for hepatic diseases. Studies in 2018 have identified subsets of hepatic cells that have unique reparative abilities and clarified the role of biomechanical forces and hepatobiliary reprogramming as sustainable modes of tissue repair.

Satdarshan P. Monga
News & Views10 Dec 2018
Nature Reviews Gastroenterology & Hepatology

Volume: 16, P: 84-86
Pten-NOLC1 fusion promotes cancers involving MET and EGFR signalings

Jian-Hua Luo
Silvia Liu
Yan-Ping Yu
Research15 Dec 2020
Oncogene

Volume: 40, P: 1064-1076
Impaired mitochondrial medium-chain fatty acid oxidation drives periportal macrovesicular steatosis in sirtuin-5 knockout mice

Eric S. Goetzman
Sivakama S. Bharathi
Satdarshan P. Monga
ResearchOpen Access27 Oct 2020
Scientific Reports

Volume: 10, P: 1-14
Learning human liver biology in humanized mice

Brandon M. Lehrich
Satdarshan P. Monga
Research Highlights20 Sept 2023
Cell Research

Volume: 34, P: 9-10
Elf3 encodes a novel 200-kD β-spectrin: role in liver development

Lopa Mishra
Tao Cai
Bibhuti Mishra
Research20 Jan 1999
Oncogene

Volume: 18, P: 353-364

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