Clamp proteins that encircle DNA and then recruit enzymes are one of nature's ways of making catalysis on DNA processive. Here, a clamp protein is equipped with a synthetic catalyst that sequence-specifically oxidizes DNA. The resulting biohybrid catalyst shows processive behaviour, which is visualized by atomic force microscopy.
- Stijn F. M. van Dongen
- Joost Clerx
- Roeland J. M. Nolte
