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Room-temperature spin transport is achieved in the d-electron-based two-dimensional electron gas at the LaAlO₃/SrTiO₃ interface.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

Three-dimensional chiral magnetic tubes created via two-photon lithography and nickel film deposition exhibit chiral spin textures and non-reciprocal magnon transport.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

It is generally assumed that modulating magnetic properties via linear excitations of Raman-active phonons is forbidden in inversion symmetric magnets. Here, Luo, Ning, Ilyas, von Hoegen, and coauthors demonstrate a linear excitation of Raman-active lattice vibrations, via magnon-polaron excitation.

Domain walls mark boundaries between magnetic regions. Here, the authors show that external radiation can efficiently propel them, leading to a state where domain walls are not static but actively moving.

In a hybrid superconductor–ferromagnet device, the dynamic stray fields of current-driven vortices unidirectionally excite coherent short-wavelength magnons.

Magnetic vortices in thin ferromagnetic films possess a core with out-of-plane magnetization whose polarity can be manipulated by magnetic fields or currents for technological applications. Here, the authors demonstrate local control of the core polarity in NiFe films via an imprinted maze domain pattern.

Ferrimagnets possess multiple spin sub-lattices resulting in a complex magnon band structure and subtle spin transport across interfaces. Here, the authors show how the spin Seebeck effect, the thermal generation of pure spin current, may be an effective tool to study these magnetic excitations.

In three dimensions, it is possible to have more complicated spin textures, one such example is a hybrid chiral skyrmion tube, where each end of the tube has skyrmions of opposite chirality. Here, Dohi, Bhukta, Kammerbauer and coauthors find that these skyrmion tubes exhibit a non-reciprocal skyrmion Hall effect.

Skyrmions and anti-skyrmions are magnetic textures that have garnered much interest due to their stability. Here, Jena et al demonstrate the existence of fractional spin textures at the edges of Heusler alloy sample, which can have continuous variable topological charges.

In this phase 1 trial of a personalized, neoantigen-specific autologous T cell therapy, BNT221, when given as monotherapy in patients with metastatic melanoma refractory to PD-1 and CTLA-4 inhibitor regimens, the therapy was safe and showed preliminary clinical activity and neoantigen-specific T cell responses.

Sub-micrometre spin waves are excited in anisotropic spin textures and they can propagate as 2D plane waves over several micrometres and as 1D waves along curved domain walls.

In this phase 1 trial, treatment of patients with solid tumors using the focal adhesion kinase (FAK) inhibitor defactinib the RAF–MEK clamp avutometinib was safe and showed encouraging clinical responses, especially in patients with low-grade serous ovarian cancer.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

In a non-prespecified interim analysis of a phase 1 trial, autologous PRAME-directed TCR T cell therapy was safe and elicited durable responses in patients with recurrent and/or treatment-refractory PRAME⁺ advanced solid tumors, including melanoma and synovial sarcoma.

Certo, Pontarini et al. provide insight into the metabolic requirements of ectopic lymphoid structure (ELS) assembly in the context of autoimmunity, and show that blocking lactate uptake by SLC5A12 offers therapeutic benefits in a mouse model of Sjögren’s disease.

The continual evolution of pathogens makes infectious disease control very challenging. Here the authors examine how host population structure influences disease evolution, and show that heterogeneous contact networks lower the fixation probability of newly arising pathogen strains.

Researchers report the direct observation of ultrafast magnetic dynamics using the magnetic component of highly intense terahertz wave pulses with a time resolution of 8 fs. This concept provides a universal ultrafast method of visualizing magnetic excitations in the electronic ground state.

The transcription factor CREM is a pivotal regulator of NK cell function, making CREM a valuable target to increase the efficacy of anticancer immunotherapies based on this cell population and chimeric antigen receptors.

The authors use nitrogen-vacancy centre magnetometry to explore layer number and magnetic field evolution of ferromagnetic and antiferromagnetic domains in the A-type antiferromagnet CrPS₄.

Chiral damping plays a critical role in the motion of skyrmions and domain walls, but it difficult to distinguish its influence from Dzyaloshinskii Moriya Interaction (DMI). Here, Safeer et al show that competition between chiral damping and the DMI result in a sign change in the chiral asymmetry.

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Interim results from the low-dose cohort of the PROCLAIM trial show that AAV-based delivery of the progranulin gene in patients with frontotemporal dementia was safe and was associated with increased CSF progranulin.

The transport and relaxation mechanisms in organic semiconductors are still insufficiently understood, but measurements now show that in these materials polarons carry pure spin currents over extended distances with long relaxation times, and uncover the role of spin-orbit coupling in this process.

Lipid nanoparticles (LNPs) delivering mRNA after intratumoral administration could be a promising cancer treatment strategy. Here this group reports the intratumoral delivery of mRNA with LNPs inducing the expression of purine nucleoside phosphorylase and inhibiting the progression of head and neck squamous cell carcinoma in vivo.

Protein sequences from fossil tooth enamel of a rhinocerotid from Canada’s High Arctic are used to develop phylogenetic frameworks from a specimen too old to preserve ancient DNA.

CMOS-based circuits can be integrated with silicon-based spin qubits and can be controlled at milli-kelvin temperatures, which can potentially help scale up these systems.

Preclinical studies indicate that myeloproliferative neoplasms (MPN) may be sensitive to the estrogen receptor modulator, tamoxifen. Here, the authors present a phase II clinical trial reporting the efficacy of tamoxifen in MPN and analysis of peripheral haematopoietic stem cells to identify potential predictive signatures of responders.

Topological solitons are localized structures whose stability emerges from the topology of their spatial structure, hence they are usually independent of the temporal dimension. The authors construct topological magnetic solitons in space-time from periodically driven magnetic structures that can be externally controlled.

The recent discovery of magnetism in van der Waals materials down to the monolayer seemed to challenge a long-established theoretical result, the Mermin-Wagner theorem, which states that long-range magnetic order does not exist in two dimensions with short-range interactions. Here, using state of the art computational methods, the authors show that for sample sizes usually used in experiments, the exchange interactions at the finite size is enough to stabilize magnetic order without any magnetic anisotropy.

The polarization direction of a ferroelectric-like state can be used to control the conversion of spin currents into charge currents at the surface of strontium titanate, a non-magnetic oxide.

Instrumental to the migration of antigen-scavenging immune cells, the lymphatic vessel entry receptor LYVE-1 interacts with the hyaluronan glycocalyx, anchored by the leucocyte hyaluronan receptor CD44. Here, dynamic force spectroscopy, crystal structures and MD simulations provide mechanistic insights.

The magnetic field-driven dynamics of nanosized magnetic vortex cores can be used to generate propagating short-wavelength spin waves in heterostructures with antiferromagnetically coupled layers.

Artificial spin ices are composed of tiny magnets arranged in a lattice. Despite their simplicity, they exhibit rich dynamic magnetic behaviour. Here, Lendinez et al demonstrate that, like continuous magnetic thin films, artificial spin ices can exhibit non-linear magnon-magnon scattering which, in conjunction with their reconfigurability, offers great potential for tuneable magnon transport.

In a large single-arm phase 2 trial, the anti-PD-1 inhibitor tislelizumab combined with the next-generation BTK inhibitor zanubrutinib had an overall response rate of 58.3% and was well tolerated in patients with Richter’s transformation.

Lysine degradation and the role of the metabolites glutarate and L-2-hydroxyglutarate have remained elusive in many organisms including Escherichia coli. Here authors present a pathway for catabolism of lysine to succinate in E. coli involving glutarate and L-2-hydroxyglutarate as intermediates.

The hypothalamic-pituitary-thyroid (HPT) axis regulates a wide range of physiological processes. Here the authors show that hypothalamic tanycytes play a role in the homeostatic regulation of the HPT axis; activation of TRH signaling in tanycytes elevates their intracellular Ca²⁺ via Gα_q/11 pathway, ultimately resulting in reduced TRH release into the pituitary vessels.

Using a globally distributed standardized aerial sampling of fungal spores, we show that the hyperdiverse kingdom of fungi follows globally highly predictable spatial and temporal dynamics, with seasonality in both species richness and community composition increasing with latitude.

The spin Peltier effect describes the temperature modulation of a system in response to a spin current and has potential application for thermal nanosensors. Here, the authors theoretically demonstrate that for an antiferromagnetic system, via the spin Peltier effect, a current driven domain wall can carry a localised heat wave with a temperature of 1 K.

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s  = 13 TeV and an integrated luminosity of 140 fb⁻¹.

Here the authors report genome-wide profiling of tRNA modifications using Induro-tRNAseq and uncover coordinated changes across cell types and tissues that underlie the basis of protein homeostasis.

Phylogenomic analysis of 7,923 angiosperm species using a standardized set of 353 nuclear genes produced an angiosperm tree of life dated with 200 fossil calibrations, providing key insights into evolutionary relationships and diversification.

This study employs a citizen science approach to identify and classify over 230,000 light sources in German city centers, suburbs and villages. The results underscore the pivotal role of citizen science in expanding knowledge of artificial light emissions and bolstering policymaking efforts to mitigate urban light pollution.