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Preliminary evidence for enhanced auditory cortex activation and mental development after gene therapy in children with autosomal recessive deafness 9

This study shows how auditory cortex activation and cognitive function develop during a six-month follow-up after gene therapy in children with congenital deafness.

Jiajia Zhang
Zengzhi Guo
Yilai Shu
Research02 May 2025
Nature Human Behaviour

Volume: 9, P: 1457-1469
Succinate dehydrogenase deficiency-driven succinate accumulation induces drug resistance in acute myeloid leukemia via ubiquitin-cullin regulation

The underlying mechanisms for drug resistance in Acute Myeloid Leukemia (AML) are not completely understood. Here, the authors show that succinate accumulation, associated with succinate dehydrogenase deficiency, impairs the activity of the ubiquitin-conjugating enzyme UBC12 leading to tumor-promoting protein accumulation and drug resistance in AML.

Yifan Chen
Miao Xian
Meidan Ying
ResearchOpen Access13 Nov 2024
Nature Communications

Volume: 15, P: 1-16
STING is a cell-intrinsic metabolic checkpoint restricting aerobic glycolysis by targeting HK2

Zhang, Jiang and colleagues demonstrate that, independent of its role in innate immunity, STING can target and inhibit HK2 activity, thereby blocking tumour aerobic glycolysis and enhancing antitumour immune responses.

Liting Zhang
Congqing Jiang
Junjie Zhang
Research13 Jul 2023
Nature Cell Biology

Volume: 25, P: 1208-1222
Bilateral gene therapy in children with autosomal recessive deafness 9: single-arm trial results

An interim analysis of a single-arm trial in 5 children with hereditary deafness shows that binaural AAV gene therapy is safe and leads to hearing improvement up to 13–26 weeks of follow-up.

Hui Wang
Yuxin Chen
Yilai Shu
ResearchOpen Access05 Jun 2024
Nature Medicine

Volume: 30, P: 1898-1904
Structural and functional characteristics of the SARS-CoV-2 Omicron subvariant BA.2 spike protein

Zhang, Tang, Gao et al. report structural and functional properties of the Omicron BA.2 spike protein, and replication kinetics of the virus. Their results suggest that both immune evasion and replicative advantage may contribute to the heightened transmissibility.

Jun Zhang
Weichun Tang
Bing Chen
Research10 Jul 2023
Nature Structural & Molecular Biology

Volume: 30, P: 980-990
A novel gene fusion RUNX1/ZNF423 promotes leukemic relapse of NUP98-rearranged AML

Wenxin Du
Zhimei Xia
Meidan Ying
Research15 Sept 2023
Leukemia

Volume: 37, P: 2286-2291
Immune escape by SARS-CoV-2 Omicron variant and structural basis of its effective neutralization by a broad neutralizing human antibody VacW-209

Bin Ju
Qingbing Zheng
Zheng Zhang
Correspondence08 Mar 2022
Cell Research

Volume: 32, P: 491-494

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Preliminary evidence for enhanced auditory cortex activation and mental development after gene therapy in children with autosomal recessive deafness 9

Succinate dehydrogenase deficiency-driven succinate accumulation induces drug resistance in acute myeloid leukemia via ubiquitin-cullin regulation

STING is a cell-intrinsic metabolic checkpoint restricting aerobic glycolysis by targeting HK2

Bilateral gene therapy in children with autosomal recessive deafness 9: single-arm trial results

Structural and functional characteristics of the SARS-CoV-2 Omicron subvariant BA.2 spike protein

A novel gene fusion RUNX1/ZNF423 promotes leukemic relapse of NUP98-rearranged AML

Immune escape by SARS-CoV-2 Omicron variant and structural basis of its effective neutralization by a broad neutralizing human antibody VacW-209

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Preliminary evidence for enhanced auditory cortex activation and mental development after gene therapy in children with autosomal recessive deafness 9

Succinate dehydrogenase deficiency-driven succinate accumulation induces drug resistance in acute myeloid leukemia via ubiquitin-cullin regulation

STING is a cell-intrinsic metabolic checkpoint restricting aerobic glycolysis by targeting HK2

Bilateral gene therapy in children with autosomal recessive deafness 9: single-arm trial results

Structural and functional characteristics of the SARS-CoV-2 Omicron subvariant BA.2 spike protein

A novel gene fusion RUNX1/ZNF423 promotes leukemic relapse of NUP98-rearranged AML

Immune escape by SARS-CoV-2 Omicron variant and structural basis of its effective neutralization by a broad neutralizing human antibody VacW-209

Search

Quick links