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Showing 1–50 of 93 results

Advanced filters: Author: Shigeki Suzuki Clear advanced filters

Stabilization of Enzyme Activity by an Organic Solvent

SHIGEKI TAKEMORI
EISUKE FURUYA
MASAYUKI KATAGIRI
Research22 Jul 1967
Nature

Volume: 215, P: 417-419
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
Intratumour oxidative hotspots provide a niche for cancer cell dissemination

Ueda et al. develop a sensor targeted to tumour cells that tracks extracellular H₂O₂. Tumour cells in H₂O₂ hotspots undergo partial epithelial–mesenchymal transition and migrate away from H₂O₂ hotspots. This is not seen in NRF2-hyperactivated tumours.

Yoshifumi Ueda
Shigeki Kiyonaka
Nobuaki Takahashi
Research21 Feb 2025
Nature Cell Biology

Volume: 27, P: 530-543
Asymmetric Anionic Polymerization of 1-Phenyldibenzosuberyl Acrylate Affording Optically Active Polymer with Helical Conformation

Toshimitsu Tanaka
Shigeki Habaue
Yoshio Okamoto
Research01 Dec 1995
Polymer Journal

Volume: 27, P: 1202-1207
Direct observation of picosecond melting and disintegration of metallic nanoparticles

Laser-matter interaction has been intensively studied in equilibrium states, but irreversible processes in a highly nonequilibrium state at nanoscales remains elusive due to experimental challenges. Here, Ihm et al. image heterogeneous melting of gold nanoparticles with nanometer and picosecond resolution.

Yungok Ihm
Do Hyung Cho
Changyong Song
ResearchOpen Access03 Jun 2019
Nature Communications

Volume: 10, P: 1-6
Genetic legacy of ancient hunter-gatherer Jomon in Japanese populations

Using biobank data from over 250,000 participants, the authors present a detailed picture of regional and individual variation in the tripartite ancestral structure of modern Japanese populations and demonstrate its impact on elevated body mass index.

Kenichi Yamamoto
Shinichi Namba
Yukinori Okada
ResearchOpen Access12 Nov 2024
Nature Communications

Volume: 15, P: 1-15
Direct creation of three-dimensional photonic crystals by a top-down approach

Fabricating defect-free three-dimensional photonic crystals over a large area is a challenge that has impeded advances in this field. The development of an etching process for creating such crystals from silicon may therefore allow a broader use of these photonic structures.

Shigeki Takahashi
Katsuyoshi Suzuki
Susumu Noda
Research09 Aug 2009
Nature Materials

Volume: 8, P: 721-725
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Changes in Electrical Resistance of Ionic Copolymers Caused by Moisture Sorption and Desorption

Noriyuki Kinjo
Shuichi Ohara
Shigeki Tsuchitani
Research01 Aug 1983
Polymer Journal

Volume: 15, P: 621-623
Establishing Reference Values for Both Total Soluble Fms-Like Tyrosine Kinase 1 and Free Placental Growth Factor in Pregnant Women

Chikako Hirashima
Akihide Ohkuchi
Mitsuaki Suzuki
Research01 Sept 2005
Hypertension Research

Volume: 28, P: 727-732
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Real-time observation of a metal complex-driven reaction intermediate using a porous protein crystal and serial femtosecond crystallography

Here the authors demonstrate the use of time-resolved serial femtosecond crystallography to capture intermediates in a chemical reaction in synthetic CO-releasing Mn-carbonyl complex fixed in lysozyme protein crystals, providing useful insights for the design of artificial metalloenzyme reactions.

Basudev Maity
Mitsuo Shoji
Takafumi Ueno
ResearchOpen Access29 Jun 2024
Nature Communications

Volume: 15, P: 1-12
Coupling of bone resorption and formation by RANKL reverse signalling

Osteoclasts secrete small extracellular vesicles that stimulate osteoblasts, promoting bone formation via receptor activator of nuclear factor-kappa B ligand (RANKL), thereby linking bone formation and resorption.

Yuki Ikebuchi
Shigeki Aoki
Hiroshi Suzuki
Research05 Sept 2018
Nature

Volume: 561, P: 195-200
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Wee1⁺-like gene in human cells

Makoto Igarashi
Akihisa Nagata
Hiroto Okayama
Research05 Sept 1991
Nature

Volume: 353, P: 80-83
Multiancestry genomic and transcriptomic analysis of gastric cancer

A cross-ancestry genomic and transcriptomic cohort of gastric cancer highlights significantly mutated genes and mutational signatures, some of which are ancestry-specific.

Yasushi Totoki
Mihoko Saito-Adachi
Tatsuhiro Shibata
Research13 Mar 2023
Nature Genetics

Volume: 55, P: 581-594
Oxidative Coupling Polymerization of Silicon-Tethered p-Alkoxyphenol Derivatives with CuCl(OH)-N,N,N′,N′-Tetramethylethylenediamine Catalyst

Shigeki Habaue
Masahiro Ohnuma
Tomohisa Temma
Research09 Aug 2005
Polymer Journal

Volume: 37, P: 625-628
Asymmetric Anionic Polymerization of N-3-Hydroxyphenyl-N-phenylacrylamide Derivatives

Takahiro Uno
Kei Shiohara
Yoshio Okamoto
Research01 Apr 1998
Polymer Journal

Volume: 30, P: 352-355
A¹⁹F NMR Signal Assignment and a Detailed Structural Study of Alternating Tetrafluoroethylene-Propylene Copolymer by High Resolution ¹⁹F NMR Spectroscopy and Computational Chemistry

Shigeki Kuroki
Reviews25 Mar 2009
Polymer Journal

Volume: 41, P: 449-454
Structure of a monomeric photosystem I core associated with iron-stress-induced-A proteins from Anabaena sp. PCC 7120

IsiAs are unique light-harvesting complexes in cyanobacteria. Here, authors solved the structure of a PSI monomer associated with six IsiAs from Anabaena by cryo-EM, which provide insights into molecular diversity and functions of different IsiAs.

Ryo Nagao
Koji Kato
Jian-Ren Shen
ResearchOpen Access17 Feb 2023
Nature Communications

Volume: 14, P: 1-13
Oxygen-evolving photosystem II structures during S₁–S₂–S₃ transitions

Serial femtosecond crystallography reveals the structural dynamics of photosystem II during the S-state transitions that produce dioxygen, providing insight into electron transfer, water insertion, proton release and O–O bond formation on sub-microsecond timescales.

Hongjie Li
Yoshiki Nakajima
Jian-Ren Shen
ResearchOpen Access31 Jan 2024
Nature

Volume: 626, P: 670-677
Chiral paddle-wheel diruthenium complexes for asymmetric catalysis

The development of chiral catalysts is of fundamental importance in asymmetric catalysis. Now, chiral paddle-wheel diruthenium complexes are reported that are stable under oxidizing conditions and effective in asymmetric C–C and C–N bond-forming reactions with turnover numbers of up to 1,880,000.

Taku Miyazawa
Takuro Suzuki
Shigeki Matsunaga
Research05 Oct 2020
Nature Catalysis

Volume: 3, P: 851-858
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population

Yuta Kochi and colleagues report a meta-analysis of genome-wide association studies for rheumatoid arthritis in a Japanese population. They identify nine loci newly associated with rheumatoid arthritis in this population and consider overlap of associations with previous studies in European populations.

Yukinori Okada
Chikashi Terao
Kazuhiko Yamamoto
Research25 Mar 2012
Nature Genetics

Volume: 44, P: 511-516
Massive image-based single-cell profiling reveals high levels of circulating platelet aggregates in patients with COVID-19

The authors report the landscape of circulating platelet aggregates in COVID-19 obtained by massive single-cell image-based profiling and temporal monitoring to elucidate the underlying process of COVID-19-assocaited microvascular thrombosis.

Masako Nishikawa
Hiroshi Kanno
Keisuke Goda
ResearchOpen Access09 Dec 2021
Nature Communications

Volume: 12, P: 1-12
Anionic Polymerization of Novel Styrene Derivatives Bearing Various Amino Groups at ortho-Position

Hiroharu Ajiro
Shigeki Habaue
Yoshio Okamoto
Research16 Apr 2004
Polymer Journal

Volume: 36, P: 323-328
Catalytic Oxidative Cross-Coupling Polymerization of Unsymmetric Binaphthol Derivatives Using Cu(I)-Bisoxazoline Complexes

Tomohisa Temma
Yusuke Takahashi
Shigeki Habaue
Research17 Apr 2007
Polymer Journal

Volume: 39, P: 524-530
Loss of heterozygosity (LOH) at 17q and 14q in human lung cancers

Pataer Abujiang
Tomoharu J Mori
Hiroshi Hiai
Research09 Dec 1998
Oncogene

Volume: 17, P: 3029-3033
Application of Quantitative Microstructural MR Imaging with Atlas-based Analysis for the Spinal Cord in Cervical Spondylotic Myelopathy

Masaaki Hori
Akifumi Hagiwara
Shigeki Aoki
ResearchOpen Access26 Mar 2018
Scientific Reports

Volume: 8, P: 1-8
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Effectiveness of ultrasound-guided fascia hydrorelease on the coracohumeral ligament in patients with global limitation of the shoulder range of motion: a pilot study

Hiroaki Kimura
Masei Suda
Hideaki Obata
ResearchOpen Access17 Nov 2022
Scientific Reports

Volume: 12, P: 1-8
Diagnostic error rates and associated factors for lower gastrointestinal perforation

Taku Harada
Takashi Watari
Taro Shimizu
ResearchOpen Access19 Jan 2022
Scientific Reports

Volume: 12, P: 1-7
A comparative study of curated contents by knowledge-based curation system in cancer clinical sequencing

Kazuko Sakai
Masayuki Takeda
Kazuto Nishio
ResearchOpen Access05 Aug 2019
Scientific Reports

Volume: 9, P: 1-8
Both higher fitness level and higher current physical activity level may be required for intramyocellular lipid accumulation in non-athlete men

Nozomu Yamasaki
Yoshifumi Tamura
Hirotaka Watada
ResearchOpen Access05 Mar 2020
Scientific Reports

Volume: 10, P: 1-7
Clinical and brain functional correlates of instrumental rigidity measurement in Parkinson’s disease

Yoshikazu Nakano
Shigeki Hirano
Satoshi Kuwabara
ResearchOpen Access07 Mar 2025
Scientific Reports

Volume: 15, P: 1-9
Expression and localization of aging markers in lacrimal gland of chronic graft-versus-host disease

Masataka Kawai
Yoko Ogawa
Kazuo Tsubota
ResearchOpen Access29 Aug 2013
Scientific Reports

Volume: 3, P: 1-6
Proliferation-Associated Expression of the MEN1 Gene as Revealed by In Situ Hybridization: Possible Role of the Menin as a Negative Regulator of Cell Proliferation Under DNA Damage

Yasuto Ikeo
Akihiro Sakurai
Kiyoshi Hashizume
Research01 Jun 2000
Laboratory Investigation

Volume: 80, P: 797-804
Public RNA-seq data-based identification and functional analyses reveal that MXRA5 retains proliferative and migratory abilities of dental pulp stem cells

Kazuma Yoshida
Shigeki Suzuki
Hideki Shiba
ResearchOpen Access20 Sept 2023
Scientific Reports

Volume: 13, P: 1-16
Silane- and peroxide-free hydrogen atom transfer hydrogenation using ascorbic acid and cobalt-photoredox dual catalysis

Hydrogen atom transfer (HAT) hydrogenation of alkenes usually requires stoichiometric silanes and peroxides. Here, the authors report a silane- and peroxide-free HAT hydrogenation method using a combined cobalt/photoredox catalysis and vitamin C as a sole stoichiometric reactant.

Yuji Kamei
Yusuke Seino
Shigeki Matsunaga
ResearchOpen Access11 Feb 2021
Nature Communications

Volume: 12, P: 1-9
Normal and High-Normal Blood Pressures, but Not Body Mass Index, Are Risk Factors for the Subsequent Occurrence of Both Preeclampsia and Gestational Hypertension: A Retrospective Cohort Study

Akihide Ohkuchi
Ryuhiko Iwasaki
Mitsuaki Suzuki
Research01 Mar 2006
Hypertension Research

Volume: 29, P: 161-167
Alteration of Serum Soluble Endoglin Levels after the Onset of Preeclampsia Is More Pronounced in Women with Early-Onset

Chikako Hirashima
Akihide Ohkuchi
Mitsuaki Suzuki
Research01 Aug 2008
Hypertension Research

Volume: 31, P: 1541-1548
Genetically encoded fluorescent thermosensors visualize subcellular thermoregulation in living cells

Genetically encoded sensors based on GFP enable the visualization of subcellular thermal changes noninvasively in intact cells.

Shigeki Kiyonaka
Taketoshi Kajimoto
Yasuo Mori
Research13 Oct 2013
Nature Methods

Volume: 10, P: 1232-1238
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Inhibition of the CXCL9-CXCR3 axis suppresses the progression of experimental apical periodontitis by blocking macrophage migration and activation

Tatsuya Hasegawa
V. Venkata Suresh
Masahiro Saito
ResearchOpen Access28 Jan 2021
Scientific Reports

Volume: 11, P: 1-15
Alterations in Placental Growth Factor Levels before and after the Onset of Preeclampsia Are More Pronounced in Women with Early Onset Severe Preeclampsia

Akihide Ohkuchi
Chikako Hirashima
Mitsuaki Suzuki
Research01 Feb 2007
Hypertension Research

Volume: 30, P: 151-159
Identification of Mycobacterium abscessus using the peaks of ribosomal protein L29, L30 and hemophore-related protein by MALDI-MS proteotyping

Satomi Takei
Kanae Teramoto
Yoko Tabe
ResearchOpen Access16 May 2024
Scientific Reports

Volume: 14, P: 1-11
Impact of aspirin on biochemical recurrence of prostate cancer after robot assisted radical prostatectomy in a multicenter retrospective cohort study

Shuhei Suzuki
Hiromitsu Negoro
Takashi Kobayashi
ResearchOpen Access15 Jan 2025
Scientific Reports

Volume: 15, P: 1-10
Genetics of rheumatoid arthritis contributes to biology and drug discovery

A genome-wide association study meta-analysis of more than 100,000 subjects of European and Asian ancestries reveals 42 new risk loci for rheumatoid arthritis, with follow-up studies identifying 98 biological candidate genes that are either already being targeted by drugs or could be in the future.

Yukinori Okada
Di Wu
Robert M. Plenge
Research25 Dec 2013
Nature

Volume: 506, P: 376-381

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