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Showing 1–50 of 84 results

Advanced filters: Author: Shin'ichi Takeda Clear advanced filters

Publisher Correction: Direct reprogramming of fibroblasts into skeletal muscle progenitor cells by transcription factors enriched in undifferentiated subpopulation of satellite cells

Naoki Ito
Isao Kii
Shin’ichi Takeda
Amendments and CorrectionsOpen Access07 Jun 2018
Scientific Reports

Volume: 8, P: 1
A mutation in the ceruloplasmin gene is associated with systemic hemosiderosis in humans

Kunihiro Yoshida
Kenichi Furihata
Nobuo Yanagisawa
Research01 Mar 1995
Nature Genetics

Volume: 9, P: 267-272
Activation of calcium signaling through Trpv1 by nNOS and peroxynitrite as a key trigger of skeletal muscle hypertrophy

Shin'ichi Takeda and colleagues show that loading of muscle results in nitric oxide creation and its conversion to peroxynitrite. The latter molecule then activates TRPV1 in the muscle, leading to increased cytoplasmic concentrations of calcium and activation of mTOR and, thus, muscle hypertrophy. They could replicate these effects without overload by treating mice with a TRPV1 agonist, suggesting a possible therapy for muscle wasting.

Naoki Ito
Urs T Ruegg
Shin'ichi Takeda
Research02 Dec 2012
Nature Medicine

Volume: 19, P: 101-106
Amber in the Cretaceous deep sea deposits reveals large-scale tsunamis

Aya Kubota
Yusuke Takeda
Yasuhiro Iba
ResearchOpen Access15 May 2025
Scientific Reports

Volume: 15, P: 1-7
Allelic loss analysis of γ-ray-induced mouse thymic lymphomas: two candidate tumor suppressor gene loci on chromosomes 12 and 16

Yasuo Matsumoto
Shin-ichi Kosugi
Ryo Kominami
Research04 Jun 1998
Oncogene

Volume: 16, P: 2747-2754
Erratum: G-CSF supports long-term muscle regeneration in mouse models of muscular dystrophy

Nozomi Hayashiji
Shinsuke Yuasa
Keiichi Fukuda
Amendments and Corrections18 Jun 2015
Nature Communications

Volume: 6, P: 1-2
Synthesis of a metal oxide with a room-temperature photoreversible phase transition

Optically driven phase transitions are widely used in optical memory devices, and the materials showing this effect are normally chalcogenides or organic compounds. Now a room-temperature light-induced phase transition between metal and semiconducting phases has been observed in a titanium oxide material.

Shin-ichi Ohkoshi
Yoshihide Tsunobuchi
Hiroko Tokoro
Research23 May 2010
Nature Chemistry

Volume: 2, P: 539-545
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Propagative α-synuclein seeds as serum biomarkers for synucleinopathies

A modified seed aggregation assay detects minute amounts of serum α-synuclein seeds in individuals with synucleinopathy, demonstrating high performance as a diagnostic biomarker.

Ayami Okuzumi
Taku Hatano
Nobutaka Hattori
ResearchOpen Access29 May 2023
Nature Medicine

Volume: 29, P: 1448-1455
Prefrontal coding of learned and inferred knowledge during REM and NREM sleep

How sleep creates novel inferential information is not fully understood. Here authors show that neuronal co-activations during NREM sleep organize the learned knowledge in a hierarchy, while co-activations during REM sleep compute the inferential information.

Kareem Abdou
Masanori Nomoto
Kaoru Inokuchi
ResearchOpen Access24 Jun 2024
Nature Communications

Volume: 15, P: 1-15
Rapid and Integrated Bacterial Evolution Analysis unveils gene mutations and clinical risk of Klebsiella pneumoniae

Authors develop and present RIBEA (Rapid and Integrated Bacterial Evolution Analysis), an approach that combines lab-based evolution experiments, genome sequencing and in vivo testing, to monitor long-term evolution or bacterial pathogenicity and antimicrobial resistance, in the context of Klebsiella pneumoniae.

Kojiro Uemura
Toyotaka Sato
Shin-ichi Yokota
ResearchOpen Access25 Mar 2025
Nature Communications

Volume: 16, P: 1-17
Hippocampus as a sorter and reverberatory integrator of sensory inputs

How the hippocampus sorts and integrates multiple sensory inputs during learning remains unclear. Here, the authors found that the hippocampus uses reverberatory activity to link conditioned and unconditioned stimuli and to avoid crosstalk during sensory inputs.

Masanori Nomoto
Emi Murayama
Kaoru Inokuchi
ResearchOpen Access20 Dec 2022
Nature Communications

Volume: 13, P: 1-15
The contribution of transcription factor IRF1 to the interferon-γ–interleukin 12 signaling axis and T_H1 versus T_H-17 differentiation of CD4⁺ T cells

Shin-ichi Kano
Kojiro Sato
Tadatsugu Taniguchi
Research02 Dec 2007
Nature Immunology

Volume: 9, P: 34-41
Development of a natural product optimization strategy for inhibitors against MraY, a promising antibacterial target

MraY (phospho-N-acetylmuramoyl-pentapeptide-transferase) inhibitory natural products are attractive candidates for the development of agents to combat antimicrobial-resistant bacteria, but their properties need to be improved by structural optimization which is challenging. Here, the authors develop a strategy for a comprehensive in situ evaluation of the build-up library, which enables streamlining of the preparation of the analogue library and direct assessment of its biological activities.

Kazuki Yamamoto
Toyotaka Sato
Satoshi Ichikawa
ResearchOpen Access14 Jun 2024
Nature Communications

Volume: 15, P: 1-15
A muscle-liver-fat signalling axis is essential for central control of adaptive adipose remodelling

Skeletal muscle proteolysis can affect organismal energy homeostasis. Here, the authors provide molecular insight into this process by showing that muscle-derived alanine acts as a signal that triggers FGF21 secretion from the liver, which then regulates lipolysis and browning of white fat tissue.

Noriaki Shimizu
Takako Maruyama
Hirotoshi Tanaka
ResearchOpen Access01 Apr 2015
Nature Communications

Volume: 6, P: 1-14
Adolescent stress impairs postpartum social behavior via anterior insula-prelimbic pathway in mice

The mechanisms of how adolescent stress causes abnormal postpartum social behavior are unclear. Here, authors show an underlying mechanism mediating by the anterior insula-prelimbic cortex pathway and glucocorticoid receptor signaling in mice.

Kyohei Kin
Jose Francis-Oliveira
Minae Niwa
ResearchOpen Access23 May 2023
Nature Communications

Volume: 14, P: 1-15
The transcription factor ATF3 switches cell death from apoptosis to necroptosis in hepatic steatosis in male mice

Aggravation of liver steatosis shifts the hepatocellular death mode from apoptosis to necroptosis in acute and chronic liver damage. Here the authors report that the transcription factor ATF3 regulates this shift through the induction of RIPK3, a regulator of necroptosis.

Yuka Inaba
Emi Hashiuchi
Hiroshi Inoue
ResearchOpen Access23 Jan 2023
Nature Communications

Volume: 14, P: 1-19
Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells

Stem cells have raised hopes of developing regenerative therapies of renal disease. Here, Osafune et al.provide a protocol for the differentiation of induced human pluripotent stem cells into renal lineages with the capacity to form tubular renal structures in mice.

Shin-Ichi Mae
Akemi Shono
Kenji Osafune
Research22 Jan 2013
Nature Communications

Volume: 4, P: 1-11
Full-length human dystrophin on human artificial chromosome compensates for mouse dystrophin deficiency in a Duchenne muscular dystrophy mouse model

Yosuke Hiramuki
Satoshi Abe
Yasuhiro Kazuki
ResearchOpen Access16 Mar 2023
Scientific Reports

Volume: 13, P: 1-8
G-CSF supports long-term muscle regeneration in mouse models of muscular dystrophy

In response to injury, satellite cells (SCs) asymmetrically divide to self-renew and repair muscle. Here the authors show that a cytokine G-CSF is crucial for long-term expansion of activated SCs and muscle regeneration in mice, suggesting that G-CSF treatment may have beneficial effect in Duchenne muscular dystrophy.

Nozomi Hayashiji
Shinsuke Yuasa
Keiichi Fukuda
Research13 Apr 2015
Nature Communications

Volume: 6, P: 1-16
Synthesis of macrocyclic nucleoside antibacterials and their interactions with MraY

MraY is a membrane enzyme required for bacterial cell wall synthesis. Here, the authors modify sphaerimicins as antibacterials targeting it via structure-based design and synthesis through two key reactions, showing a platform for further development of MraY inhibitors as antibacterials.

Takeshi Nakaya
Miyuki Yabe
Satoshi Ichikawa
ResearchOpen Access20 Dec 2022
Nature Communications

Volume: 13, P: 1-13
Spatiotemporal dynamics of SETD5-containing NCoR–HDAC3 complex determines enhancer activation for adipogenesis

How enhancers transition from a hypoacetylated primed state to a hyperacetylated-active state in response to differentiation stimuli is incompletely understood. Here the authors show that SETD5 forms a complex with NCoR-HDAC3 co-repressor to prevent histone acetylation of master adipogenic gene enhancers, while SETD5 degradation triggers enhancer hyperacetylation and transition to active state.

Yoshihiro Matsumura
Ryo Ito
Juro Sakai
ResearchOpen Access02 Dec 2021
Nature Communications

Volume: 12, P: 1-19
Viable offspring obtained from Prm1-deficient sperm in mice

Naoki Takeda
Kazuya Yoshinaga
Ken-ichi Yamamura
ResearchOpen Access02 Jun 2016
Scientific Reports

Volume: 6, P: 1-12
The enzymatic activity of inositol hexakisphosphate kinase controls circulating phosphate in mammals

Inositol hexakisphosphate kinase (IP6K) is involved in diverse cellular signalling pathways, but the physiological roles of IP6K in vivo remain unknown in mammals. Here, the authors show that the enzymatic activity of IP6K is essential for phosphate regulation in vivo.

Yusuke Moritoh
Shin-ichi Abe
Masanori Watanabe
ResearchOpen Access11 Aug 2021
Nature Communications

Volume: 12, P: 1-15
Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle

Ectopic adipocytes in skeletal muscle are observed in several disorders, but their origin is unclear. PDGFRα+ mesenchymal progenitors are identified as responsible for ectopic adipogenesis, which is inhibited by the presence of satellite cell-derived myofibres.

Akiyoshi Uezumi
So-ichiro Fukada
Kunihiro Tsuchida
Research17 Jan 2010
Nature Cell Biology

Volume: 12, P: 143-152
Cardiac-Restricted Ankyrin-Repeated Protein Is Differentially Induced in Duchenne and Congenital Muscular Dystrophy

Chisato Nakada
Yoshiyuki Tsukamoto
Masatsugu Moriyama
Research01 May 2003
Laboratory Investigation

Volume: 83, P: 711-719
Assessing Cell-to-Cell DNA Methylation Variability on Individual Long Reads

Wei Qu
Tatsuya Tsukahara
Shinichi Morishita
ResearchOpen Access18 Feb 2016
Scientific Reports

Volume: 6, P: 1-7
Manumycin A corrects aberrant splicing of Clcn1 in myotonic dystrophy type 1 (DM1) mice

Kosuke Oana
Yoko Oma
Shoichi Ishiura
ResearchOpen Access05 Jul 2013
Scientific Reports

Volume: 3, P: 1-7
Do Eicosapentaenoic Acid Supplements Attenuate Age-Related Increases in Arterial Stiffness in Patients with Dyslipidemia?: A Preliminary Study

Hirofumi Tomiyama
Kenji Takazawa
Akira Yamashina
Research01 Aug 2005
Hypertension Research

Volume: 28, P: 651-655
Promotion of early osteoclastogenesis and B lymphopoiesis in the bone marrow of transgenic rats with the env-pX gene of human T-cell lymphotropic virus type I

Hidetoshi Yamazaki
Takahiro Kunisada
Takashi Yoshiki
Research09 Dec 1998
Oncogene

Volume: 17, P: 2955-2960
Digital detection of Alzheimer’s disease using smiles and conversations with a chatbot

Haruka Takeshige-Amano
Genko Oyama
Nobutaka Hattori
ResearchOpen Access01 Nov 2024
Scientific Reports

Volume: 14, P: 1-10
Metal nanoparticles in the presence of lipopolysaccharides trigger the onset of metal allergy in mice

Mice pre-treated with lipopolysaccharides and metal nanoparticles, 10 nm or smaller, can cause a CD4⁺ T-cell-dependent allergic response similar to metal allergy seen in humans, suggesting that metal nanoparticles could potentially be a new trigger for metal allergy.

Toshiro Hirai
Yasuo Yoshioka
Yasuo Tsutsumi
Research30 May 2016
Nature Nanotechnology

Volume: 11, P: 808-816
Development of peripheral lymphoid organs and natural killer cells depends on the helix–loop–helix inhibitor Id2

Yoshifumi Yokota
Ahmed Mansouri
Peter Gruss
Research25 Feb 1999
Nature

Volume: 397, P: 702-706
Mutations in the WFS1 gene are a frequent cause of autosomal dominant nonsyndromic low-frequency hearing loss in Japanese

Hisakuni Fukuoka
Yukihiko Kanda
Shin-ichi Usami
Research11 May 2007
Journal of Human Genetics

Volume: 52, P: 510-515
Silica and titanium dioxide nanoparticles cause pregnancy complications in mice

Pregnant mice treated with silica and titanium dioxide nanoparticles show abnormalities in the placenta and have smaller uterine and fetuses than untreated control mice and those receiving larger particles.

Kohei Yamashita
Yasuo Yoshioka
Yasuo Tsutsumi
Research03 Apr 2011
Nature Nanotechnology

Volume: 6, P: 321-328
Quantitative PCR methodology with a volume-based unit for the sophisticated cellular kinetic evaluation of chimeric antigen receptor T cells

Syunsuke Yamamoto
Shin-ichi Matsumoto
Hideki Hirabayashi
ResearchOpen Access21 Oct 2020
Scientific Reports

Volume: 10, P: 1-10
Pathogenic exon-trapping by SVA retrotransposon and rescue in Fukuyama muscular dystrophy

Mariko Taniguchi-Ikeda
Kazuhiro Kobayashi
Tatsushi Toda
Research05 Oct 2011
Nature

Volume: 478, P: 127-131
Efficacy of elotuzumab for multiple myeloma in reference to lymphocyte counts and kappa/lambda ratio or B2 microglobulin

Yutaka Shimazu
Junya Kanda
Junya Kuroda
ResearchOpen Access29 Mar 2023
Scientific Reports

Volume: 13, P: 1-12
Characterization of the kinase activity essential for tyrosine phosphorylation of p130^Cas in fibroblasts

Ryuichi Sakai
Tetsuya Nakamoto
Hisamaru Hirai
Research27 Mar 1997
Oncogene

Volume: 14, P: 1419-1426
Autologous or allogeneic hematopoietic cell transplantation for relapsed or refractory PTCL-NOS or AITL

Kazuaki Kameda
Shinichi Kako
Eisei Kondo
Research28 Mar 2022
Leukemia

Volume: 36, P: 1361-1370
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
Functional visualization and disruption of targeted genes using CRISPR/Cas9-mediated eGFP reporter integration in zebrafish

Satoshi Ota
Kiyohito Taimatsu
Atsuo Kawahara
ResearchOpen Access11 Oct 2016
Scientific Reports

Volume: 6, P: 1-10
The prevalence and clinical features of MYO7A-related hearing loss including DFNA11, DFNB2 and USH1B

Kizuki Watanabe
Shin-ya Nishio
Shunsuke Kondo
ResearchOpen Access09 Apr 2024
Scientific Reports

Volume: 14, P: 1-19
Duchenne muscular dystrophy

Duchenne muscular dystrophy is an X-linked progressive, muscle-wasting disease that manifests in childhood as difficulties with movement. This Primer by Aartsma-Rus and colleagues discusses the clinical presentation, epidemiology, pathophysiology, genetic diagnosis and treatment of this disorder.

Dongsheng Duan
Nathalie Goemans
Annemieke Aartsma-Rus
Reviews18 Feb 2021
Nature Reviews Disease Primers

Volume: 7, P: 1-19
The medaka draft genome and insights into vertebrate genome evolution

The medaka fish (Oryzias latipes) has long been a popular pet in Japan and more recently a laboratory model organism; it now has its genome sequenced and analysed by a Japanese consortium.

Masahiro Kasahara
Kiyoshi Naruse
Yuji Kohara
ResearchOpen Access07 Jun 2007
Nature

Volume: 447, P: 714-719
Initial Pulmonary Respiration Causes Massive Diaphragm Damage and Hyper-CKemia in Duchenne Muscular Dystrophy Dog

Akinori Nakamura
Masanori Kobayashi
Shin'ichi Takeda
ResearchOpen Access15 Jul 2013
Scientific Reports

Volume: 3, P: 1-9
Author Correction: Direct reprogramming of fibroblasts into skeletal muscle progenitor cells by transcription factors enriched in undifferentiated subpopulation of satellite cells

Naoki Ito
Isao Kii
Shin’ichi Takeda
Amendments and CorrectionsOpen Access25 Apr 2018
Scientific Reports

Volume: 8, P: 1
DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine–producing metabolic pathway

Proper bone structure is dependent on metabolism-mediated epigenetic regulation of osteoclast development.

Keizo Nishikawa
Yoriko Iwamoto
Masaru Ishii
Research23 Feb 2015
Nature Medicine

Volume: 21, P: 281-287
Targeted expression of step-function opsins in transgenic rats for optogenetic studies

Hiroyuki Igarashi
Keiko Ikeda
Hiromu Yawo
ResearchOpen Access03 Apr 2018
Scientific Reports

Volume: 8, P: 1-12
Cortisol overproduction results from DNA methylation of CYP11B1 in hypercortisolemia

Mitsuhiro Kometani
Takashi Yoneda
Yoshiyu Takeda
ResearchOpen Access11 Sept 2017
Scientific Reports

Volume: 7, P: 1-9

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