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High-density multimodal soft bioelectronic fibres provide a platform for minimally invasive implantable electronics, where diverse sensing and stimulation functionalities can be effectively integrated.

Using extended-gate capacitive coupling and diode connection, stretchable biosensors with a built-in differential circuit design can be created that can offer low signal distortion under bias stress instability, uniaxial strain, compression and temperature variations.

To date, experimental induction of hair cell regeneration in mammals leads to immature and poorly differentiated hair cells. Here the authors show that the transcription factor prdm1a plays a crucial role in specifying sensory hair cell types with loss of prdm1a in zebrafish leading to misspecification of hair cells in the sensory lateral line system into ear hair cells.

This work demonstrates that epitaxial match at the oxide-support interfaces plays a critical role in determining whether supported metal nanoparticles oxidize from the interface or the free surface in oxygen, thereby enabling controlled oxidation.

Proliferation of adult tissue stem cells is tightly regulated to balance maintenance of the tissue against stem cell exhaustion or cancerous expansion. Here they show that zebrafish lateral line progenitors are differentially regulated by two cyclinD genes, which control developmental and adult progenitor proliferation as well as hair cell polarization.

ZrCo, a promising hydrogen isotope storage material, has poor cyclic storage capacity. Here author reveal a defect-derived disproportionation mechanism and report a nano-single-crystal strategy to comprehensively improve performances.

Controlling Li nucleation and growth is crucial to avoid dendrite formation. Here, Li₂S(111)@Cu is used as Li metal electrode substrate, where a substrate-dependent Li nucleation process and a facet-dependent growth mode are identified, enabling dense Li deposition and improved battery performance.

A three-photon miniature microscope with optimized light-collection efficiency facilitates imaging of neuronal activity throughout the cortex, as well as in the hippocampus, in freely moving mice.

Wang et al. profile the translatome of haematopoietic stem cells (HSCs) and downstream progenitors and lineages. They identify the SNORD113–114 cluster as a modulator of translation and self-renewal in HSCs.

Functional divergence of CYP76AK subfamily, accompanied by oxidation variations at C-20, leads to diverse abietane-type diterpenoids in Salvia species. Enzyme activity loss contributes to this unique chemical diversity within the lineage.

In situ liquid-cell electrochemical transmission electron microscopy allows the direct visualization of the transformation of lithium polysulfides over electrode surfaces at the atomic scale, leading to a new energy-storage mechanism in lithium–sulfur batteries.

Statins have anti-cancer effects that are modulated by the gut commensal Lactobacillus reuteri and the tryptophan metabolite, indole-3-lactic acid, in mice and humans.

Slowly evolving cnidarians are useful models to study genome architecture. This study shows that sea anemones have a high degree of chromosomal macrosynteny, but poor microsynteny conservation. This is correlated with a small genome size and short distances of cis-regulatory elements to genes.

In situ synchrotron X-ray tools are used to perform microstrain screening during solid-state synthesis of battery materials, leading to fewer structural defects and improved performance.

Using electrostatic doping, the real and imaginary parts of the refractive index along the extraordinary axis of semiconducting, highly aligned, single-walled carbon nanotubes over 4″ wafers can be tuned by up to 5.9% and 14.3% in the infrared at 2,200 nm and 1,660 nm, respectively.

Layered oxide cathode materials for sodium-ion batteries often experience irreversible phase transitions and structural instability. Now researchers have developed a P2-type oxide containing earth-abundant elements, featuring an intergrowth phase structure that enables long-cycle, high-energy sodium-ion batteries.

Here, the authors use multi-omic data to reveal how genetic and epigenetic variation affects gene expression in two pig breeds. The findings highlight strong tissue-specific regulation and identify genes with allele-specific expression.

Mediator subunit MED26 was shown to help recruit Super Elongation Complex (SEC) or Little Elongation Complex (LEC) to control the expression of certain genes. Here, the authors provide evidence that MED26 recruits LEC to regulate transcription termination of non-polyadenylated genes, including snRNA and replication-dependent histone (RDH) genes at Cajal bodies.

Natural disasters can obstruct first responders when and where they are needed most. This analysis models the response of emergency service stations during flooding events in England to find major impacts on ambulance and fire services at a time of escalating flood risks to the country.

Targeting resistant stem cells in leukaemia, Perry et al. show that doxorubicin at low doses decreases Akt-mediated β-catenin activity, downregulates expression of multiple immune-checkpoint genes and dampens tumorigenesis of leukaemia stem cells.

Benham-Pyle et al. present a single-cell analysis of planarian regeneration and identify rare amputation-specific cell states in the muscle, epidermis and intestine that are required for patterning and stem cell proliferation.

Comparing Mexican cavefish from rivers with those from caves, the authors show increased sensitivity of the innate and adaptive immune system that is accompanied by a reduced investment in the innate immune system as an evolutionary response to lower parasite diversity.

A two-photon miniature microscope with enlarged field of view and axial scanning capabilities has been developed and applied in freely moving mice.

Blind and partially sighted individuals face considerable challenges when interacting with digital information. This Perspective highlights important bottlenecks in information accessibility, design considerations for future wearable assistive devices and the outlook for improved access to and delivery of information in text and images.

This method monochromatizes broadband diffraction patterns from unknown ultra-broadband illumination while simultaneously determining the diffracted radiation’s spectral features in an ultra-broadband imaging system.

Ultra-simplified compact spectrometer with a simple, arbitrarily shaped pinhole as the diffracted disperser, eliminating need for encoding and full spectrum calibration, and achieving better than 3 nm spectral peak resolution.