Branched ubiquitin chains promote substrates degradation. Here, the authors describe an interplay between two ubiquitin ligases, K29-linkage-specific TRIP12 and K48-linkage specific UBR5, which assembles K29/K48 branched ubiquitin chains and facilitates degradation of deubiquitylation-protected substrates.
- Mai Morita
- Miyu Takao
- Fumiaki Ohtake