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Organic electrochemical neuron sensors enable rapid, energy-efficient neural signal detection and modulation, supporting closed-loop neuromodulation and offering a promising platform for implantable neurotherapeutic applications.

Cullin-RING ligases are regulated by the COP9 signalosome (CSN) through deneddylation. Here, authors report high-resolution cryo-EM structures that capture catalytic and dissociation intermediates, identify CSNAP within the complex, and reveal a stepwise pathway for CSN disengagement.

Here, Yang-Jensen et al. demonstrate that a scalable microbial protein lysate from Methylococcus capsulatus Bath reshapes gut microbiota and T cells and, via fermentation-driven GLP-2 receptor mimicry, protects against gastrointestinal inflammation while providing sustainable protein nutrition

The authors use time-resolved scanning near-field optical microscopy to probe the ultrafast excitonic processes and their impact on waveguide operation in transition metal dichalcogenide crystals. They observe significant modulation of the complex index by monitoring waveguide modes on the fs time scale, and identify both coherent and incoherent manipulations of WSe₂ excitonic resonances.

TDP-43 dysfunction in ALS/FTD causes faulty splicing of the KCNQ2 ion channel, leading to toxic protein buildup, neuron hyperactivity and a potential new biomarker and treatment target using RNA-based therapies.

Quantum-dot-based single photon sources represent a promising resource for future quantum networks. Here, the authors realize all-photonic quantum teleportation using photons from two remote near-infrared-emitting quantum dots, using polarization-preserving quantum frequency converters to enable two-photon interference at telecom wavelength.

SARS-CoV-2 vaccination has shown reduced efficacy in patients with haematological malignancies. Here, the authors show that a third vaccine is able to enhance SARS-CoV-2 antibody responses in most cases in a cohort of 381 patients with haematological malignancies.

The authors theoretically study the pressure dependence of the phase diagram of the nickelate PrNiO₂ with and without Sr doping. At high pressure, they find that the superconducting dome is significantly enhanced in both T_c and doping-range of superconductivity compared with ambient pressure, with a maximal T_c of 100 K around 100 GPa in absence of external doping.

Human children use referential gestures such as showing, offering and pointing, which are thought to form the foundation of language skills. Here, evidence is provided of ravens (Corvus corax) using showing and offering to direct other's attention, as an example of referential gesturing in a non-primate lineage.

The precision of determining the phase of an optical atomic clock is increased above the standard quantum limit in a new spectroscopic method.

Pathogenic variants in UNC13A underlie a novel neurodevelopmental syndrome, with three subtypes defined by distinct genotypes with varying clinical and functional impacts characterized in cellular and animal models.

In two-dimensional semiconductors excitons are strongly bound, suppressing the creation of free carriers. Here, the authors investigate the main exciton dissociation pathway in p-n junctions of monolayer WSe₂ by means of time and spectrally resolved photocurrent measurements.

Topological antiferromagnetic states are generated and spatially reconfigured in free-standing crystalline membranes of haematite through strain design.

PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.

Does trust in science drive intentions for health-related behaviour? Across four studies employing an experimental manipulation of trust in science, no evidence emerged to support a causal link between the two.

The use of organic photoactive materials in direct solar water-splitting devices has been limited by recombination losses and their instability in aqueous media. Daboczi et al. report that stable and efficient devices based on organic photoactive layers can be achieved through the application of catalyst-functionalized protective graphite sheets.

Chemical approaches to improve aqueous dispersions of conjugated polymers are limited by the feasibility of modifying the backbone or lead to poor performance. Here, Liu et al. show that ground-state electron transfer in donor:acceptor blends aids aqueous dispersion, for high conductivity and solubility.

Beth Simone Noveck enjoys a seasoned wonk’s analysis of the potential and pitfalls of large-scale collaboration.

The arcuate fascicle connection with the middle temporal gyrus has been considered unique to humans. Using high-resolution diffusion MRI, the authors systematically show this connection in chimpanzees, suggesting a gradual evolution of the language network.

Group-IV nanowires hold great promise for building ideal light sources for photonic integrated circuits. This study presents an observation of cavity resonances in a single GeSn nanowire, laying the foundation for realizing group-IV nanowire lasers.

Information leaked by a quantum system into its environment causes decoherence but if it is recorded then it can be used to infer the quantum state. Ficheux et al. monitor the relaxation and dephasing of a qubit and show that this allows all three components of the qubit to be probed simultaneously.

Here the authors spatially map human pediatric low-grade gliomas using imaging mass cytometry, focusing on immunosuppressive myeloid cell populations and their functionality in tumor–immune interactions and tumor progression.

Here, Marcado-Evans et al show that gestational diabetes enhances group B Streptococcus infection through altering host-microbe dynamics, disrupting maternal immunity, and perturbing the vaginal microbiota in a murine pregnancy model.

Aging dynamics of complex lipids are incompletely understood. Here Janssens and colleagues describe lipids that change with age across ten tissues in mice. Notably, bis(monoacylglycerol)phosphate accumulated with age. This lipid also accumulated in muscle of older humans, and reduced upon a short bout of exercise.

Hansen et al. used in vivo functional imaging of the human brainstem and cortex to demonstrate how the brainstem shapes cortical functional architecture, including oscillatory dynamics, cognitive specialization and hierarchical organization.

HistoPlexer, a deep learning model, generates multiplexed protein expression maps from H&E images, capturing tumour–immune cell interactions. It outperforms baselines, enhances immune subtyping and survival prediction and offers a cost-effective tool for precision oncology.

TMEM16F is a transmembrane protein that facilitates passive phospholipid transbilayer movement and ion conduction across membranes. Here, authors reveal a structural heterogeneity which is possibly linked to TMEM16F unique dual function.

A quantum-to-quantum Bernoulli factory is demonstrated by using a reconfigurable Clements’s squared unitary circuit in an integrated quantum photonic platform. Three interferometer designs are proposed for the basic operations of a field on qubit states.

The therapeutic options for castration-resistant prostate cancer (CRPC) remain limited. Here, the authors highlight the role of methionine adenosyltransferase 2a (MAT2A) in epigenetic reprogramming and suggest its therapeutic targeting in CRPC.

The immunological parameters that define severe influenza disease are not clear within human real time infections. Here the authors compare a severe influenza infection cohort with an influenza vaccinated cohort to understand correlates of severe influenza disease.

Rare tumour specific mutations in patient samples act as markers to monitor the course of disease. Here the authors report superRCA assays for rapid, highly specific detection of DNA sequence variants present at very low frequencies in DNA samples with flow cytometry readout; they use this on AML patients.

Islet transplantation for type 1 diabetes management is hindered by the life-long need for immunosuppressive medications. Here, the authors report an islet encapsulation device with local anti-rejection drug release that achieves long-term diabetes reversal in male rats and reduces drug-related toxicity.

Exploiting optical multimodal confinement, the deep-subwavelength confinement of hyperbolic phonon polaritons is demonstrated in isotopically pure hexagonal boron nitride, enabling nanoscale polariton manipulation.

Current methods to generate spheroids are associated with low production throughputs, limiting clinical and industrial translation. Here the authors present a clean ultra-high-throughput in-air microfluidic platform for mass production of lumenogenic embryoid bodies and functional cardiospheres.

In the Tumor Profiler proof-of-concept observational study, a multiomics approach for profiling tumors from patients with melanoma was feasible, returning data within 4 weeks and informing treatment recommendations in 75% of cases.

A report from the Australian Acute Care Genomics programme shows that the integration of rapid whole-genome sequencing and multi-omic analyses informs diagnoses and treatment decisions in a prospective cohort of 290 critically ill infants and children.

Cryo-EM structures and analysis provide insight into the mechanisms by which basic helix–loop–helix transcription factors access E-box DNA sequences that are embedded within nucleosomes, and cooperate with other transcription factors.

An in-depth understanding of the molecular pathogenesis of fibrolamellar carcinoma (FLC) is hampered due to limited human preclinical models. Here the authors engineer human organoids to reflect different FLC genetic backgrounds and show that hepatocytes can be a cell-of-origin of FLC that transdifferentiate into ductal/progenitor like cells due to combined BAP1 and PRKAR2A loss.

CD62L⁺ precursors of exhausted T cells retain long-term proliferative potential, multipotency and repopulation capacity, and the transcription factor MYB is essential for the development and function of this population of cells.

Adding to the recent debate on the role of epithelial–mesenchymal transition (EMT) in cancer cell invasion and metastasis, Brabletz and colleagues show that the EMT-inducing transcription factor Zeb1 drives pancreatic tumorigenesis and metastasis.

Gene fusions involving the ERG transcription factor and point mutations in the ubiquitin ligase adaptor SPOP are two truncal mutations that are mutually exclusively present in prostate cancer. Here, the authors show that mutations in SPOP render prostate tumor cells sensitive to antiandrogen therapy and that the presence of ERG promotes sensitivity to high dose of androgen and SPOP inhibition.

We combine data from global forest resource assessments with a forest model to quantify the role of major drivers of net carbon fluxes from global forest biomass at national resolution between 1990 and 2020. We find that growth-condition changes, more than reforestation, counteracted forest biomass carbon emissions mostly driven by deforestation.

Electrons and holes in doped quantum wells cannot form bound states from usual Coulomb interaction. However, when the system is embedded in a cavity, the exchange of photons provides an effective attraction, leading to the creation of bound excitons.

Murine norovirus protects intestinal epithelial cells (IECs) from chemical injury by inducing a type I interferon (IFN-I) response in the colon via the viral non-structural protein NS1/2. IFN-I signalling in IECs, in turn, stimulates the production and signalling of the cytoprotective cytokine interleukin-22.

Pre conditioning injury or environmental enrichment have been shown to promote axon regeneration. Here the authors show that environmental enrichment, combined with preconditioning injury promotes regeneration via a redox signalling dependent mechanism.

Climate extremes, exposure and vulnerability all contribute to global difference in heatwave risk. Here the authors investigated the inequality in global heatwave risk under both 1.5 and 2 °C scenarios and found that heatwave risk for the poor under 1.5 °C scenario exceeds that risk for the rich under 2 °C scenario.