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Showing 1–10 of 10 results
Advanced filters: Author: Sita M Bierma-Zeinstra Clear advanced filters

  • Identifying different phenotypes of osteoarthritis is currently a subject of much research; however, a new systematic review has sparked discussion about the discrepancies in how research into disease phenotypes is conducted. Can we define individual phenotypes if we cannot agree on what constitutes a phenotype in the first place?

    • Sita M. Bierma-Zeinstra
    • Marienke van Middelkoop
    News & Views
    Nature Reviews Rheumatology
    Volume: 13, P: 705-706

  • Skeletal abnormalities of the hip can place unnecessary stress on structures within the hip. One of these abnormalities, in which the head of the femur develops a cam-shaped outgrowth, has been associated with the subsequent development of osteoarthritis. In this Perspectives, the etiology of cam abnormalities and their contribution to osteoarthritis are discussed.

    • Rintje Agricola
    • Jan H. Waarsing
    • Sion Glyn-Jones
    Reviews
    Nature Reviews Rheumatology
    Volume: 9, P: 630-634

  • Cam morphology can cause intra-articular joint damage and lead to femoroacetabular impingement syndrome and eventually hip osteoarthritis. This Review explores the development and effect of cam morphology on femoroacetabular impingement syndrome and hip osteoarthritis, discussing relevant terminology, diagnostic approaches, pathophysiological insights and management strategies.

    • Joshua Heerey
    • Joanne Kemp
    • Rintje Agricola
    Reviews
    Nature Reviews Rheumatology
    Volume: 22, P: 199-212

  • The SARS-CoV-2 Omicron variant is associated with less severe disease but less is known about variant-specific risk of long-term complaints. Monitoring 1.3 million individuals from Norway for post-acute COVID-19 complaints up to 126 days shows that the burden is similar for Omicron and Delta for most complaints except for musculoskeletal pain.

    • Karin Magnusson
    • Doris Tove Kristoffersen
    • Jonas Minet Kinge
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-9

  • Alterations to the microbiome are now associated with various diseases. Here the authors analyze microbiomes from a large population based cohort and show positive correlations between abundance of Streptococcus spp. and osteoarthritis-related knee pain.

    • Cindy G. Boer
    • Djawad Radjabzadeh
    • Joyce B. J. van Meurs
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-9

  • Aida Bertoli-Avella and colleagues report the identification of SMAD3 mutations in individuals with a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis. The mutations cause increased aortic expression of components of the TGF-β signaling pathway.

    • Ingrid M B H van de Laar
    • Rogier A Oldenburg
    • Aida M Bertoli-Avella
    Research
    Nature Genetics
    Volume: 43, P: 121-126

  • Osteoarthritis is a complex, multifactorial disorder affecting the entire joint that can cause pain and is a leading cause of disability and premature work loss. In this Primer, Tang and colleagues summarize the epidemiology, pathophysiology, diagnosis and management of osteoarthritis and highlight the global burden of the disease.

    • Su’an Tang
    • Changqing Zhang
    • David J. Hunter
    Reviews
    Nature Reviews Disease Primers
    Volume: 11, P: 1-22

  • Establishing suitable outcome measures is an important goal for the classification and monitoring of patients with early knee osteoarthritis. This Perspectives article highlights various outcome measures that have potential use in clinical and/or research settings for early knee osteoarthritis.

    • Carolyn A. Emery
    • Jackie L. Whittaker
    • Nigel K. Arden
    Reviews
    Nature Reviews Rheumatology
    Volume: 15, P: 438-448