Nature Search

Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus

Here the authors perform a trans expression quantitative trait locus meta-analysis study of over 3,700 people and link a USP18 variant to expression of 50 inflammation genes and lupus risk, highlighting how genetic regulation of immune responses drives autoimmune disease and informs new therapies.

Krista Freimann
Anneke Brümmer
Kaur Alasoo
ResearchOpen Access02 Oct 2025
Nature Communications

Volume: 16, P: 1-15
Functional analysis of the regulatory requirements of B-Raf and the B-Raf^V600E oncoprotein

T Brummer
P Martin
M Reth
Research15 May 2006
Oncogene

Volume: 25, P: 6262-6276
Gab2 and Src co-operate in human mammary epithelial cells to promote growth factor independence and disruption of acinar morphogenesis

H L Bennett
T Brummer
R J Daly
Research12 Nov 2007
Oncogene

Volume: 27, P: 2693-2704
Uptake of Amino-Acids by the Fungus Botrytis Fabae

O. T. G. JONES
W. A. WATSON
Research09 Jun 1962
Nature

Volume: 194, P: 947-948
The gut hormone Allatostatin C/Somatostatin regulates food intake and metabolic homeostasis under nutrient stress

Intestinal nutrient-sensing is important in metabolic control. Here the authors show that the gut-derived hormone Allatostatin C, a somatostatin homolog in fruit flies, links enteric nutrient sensing to behavioral and metabolic adaptations that maintain energetic homeostasis in Drosophila melanogaster.

Olga Kubrak
Takashi Koyama
Kim Rewitz
ResearchOpen Access04 Feb 2022
Nature Communications

Volume: 13, P: 1-17
Particle acceleration at planetary bow shock waves

M. M. Hoppe
C. T. Russell
Research07 Jan 1982
Nature

Volume: 295, P: 41-42
Exploring the potential of the COI gene marker for DNA barcoding of planktonic foraminifera

Ana Carolina Bercini Gusmao
Robin L. van Dijk
Raphaël Morard
ResearchOpen Access01 Jun 2025
Scientific Reports

Volume: 15, P: 1-10
Functioning haemoglobin genes in non-nodulating plants

Didier Bogusz
Cyril A. Appleby
W. James Peacock
Research01 Jan 1988
Nature

Volume: 331, P: 178-180
CEACAM1: contact-dependent control of immunity

Members of the carcinoembryonic-antigen-related cell-adhesion molecule (CEACAM) family are involved in intercellular binding interactions affecting various normal and pathogenic processes. This article provides an overview of the role of CEACAMs in immunity, focusing on the function of CEACAM1.

Scott D. Gray-Owen
Richard S. Blumberg
Reviews01 Jun 2006
Nature Reviews Immunology

Volume: 6, P: 433-446
Premature Induction of Labor with Dilinoleyl Lecithin in Rabbits

Jonathan T Lanman
Llewellyn Herod
Rosemarie Thau
Research01 Jul 1972
Pediatric Research

Volume: 6, P: 701-704
Premature Induction of Labor with Dilinoleyl Lecithin in Rabbits

Jonathan T Lanman
Llewellyn Herod
Rosemarie Thau
Research01 Sept 1972
Pediatric Research

Volume: 6, P: 701-704
MAPK inhibitor sensitivity scores predict sensitivity driven by the immune infiltration in pediatric low-grade gliomas

The MAPK pathway is a key driver of pediatric low-grade gliomas (pLGG); however, response to MAPK inhibitors (MAPKi) in pLGG patients is not consistent. Here, the authors develop MAPKi sensitivity scores (MSS) to predict response to MAPKi and apply them to bulk and single-cell sequencing datasets from pLGG patients and preclinical models.

Romain Sigaud
Thomas K. Albert
Till Milde
ResearchOpen Access27 Jul 2023
Nature Communications

Volume: 14, P: 1-21
Identification of clinical disease trajectories in neurodegenerative disorders with natural language processing

Analyzing clinical records from a cohort of 3,042 donors in the Netherlands Brain Bank, natural language processing models unveil the symptomatology and potential misdiagnoses of a broad range of neurodegenerative disorders.

Nienke J. Mekkes
Minke Groot
Inge R. Holtman
ResearchOpen Access12 Mar 2024
Nature Medicine

Volume: 30, P: 1143-1153
Multi-omics dissection of MAPK-driven senescence unveils therapeutic vulnerabilities in KIAA1549::BRAF-fusion pediatric low-grade glioma models

Romain Sigaud
Anja Stefanski
Till Milde
ResearchOpen Access23 Jun 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-15
The GAB2 signaling scaffold promotes anchorage independence and drives a transcriptional response associated with metastatic progression of breast cancer

A Mira
C Isella
E Medico
Research19 Oct 2009
Oncogene

Volume: 28, P: 4444-4455
Pre-breeding in alfalfa germplasm develops highly differentiated populations, as revealed by genome-wide microhaplotype markers

Cesar A. Medina
Dongyan Zhao
Zhanyou Xu
ResearchOpen Access08 Jan 2025
Scientific Reports

Volume: 15, P: 1-15
The FORCIS database: A global census of planktonic Foraminifera from ocean waters

Sonia Chaabane
Thibault de Garidel-Thoron
Patrizia Ziveri
ResearchOpen Access03 Jun 2023
Scientific Data

Volume: 10, P: 1-16
Author Correction: Pre-breeding in alfalfa germplasm develops highly differentiated populations, as revealed by genome-wide microhaplotype markers

Cesar A. Medina
Dongyan Zhao
Zhanyou Xu
Amendments and CorrectionsOpen Access08 Apr 2025
Scientific Reports

Volume: 15, P: 1
Role of CEACAM1 isoforms in an in vivo model of mammary morphogenesis: mutational analysis of the cytoplasmic domain of CEACAM1-4S reveals key residues involved in lumen formation

S Yokoyama
C-J Chen
J E Shively
Research04 Jun 2007
Oncogene

Volume: 26, P: 7637-7646
Role of Gab2 in mammary tumorigenesis and metastasis

Y Ke
D Wu
G-S Feng
Research19 Feb 2007
Oncogene

Volume: 26, P: 4951-4960
Recurrent MET fusion genes represent a drug target in pediatric glioblastoma

Whole-genome sequencing identified recurrent fusions involving the MET oncogene, and MET inhibitors suppressed tumor growth in mouse models and in a human patient.

Sebastian Bender
Jan Gronych
David T W Jones
Research17 Oct 2016
Nature Medicine

Volume: 22, P: 1314-1320
Stability of Interindividual Differences in Serotonin Function and Its Relationship to Severe Aggression and Competent Social Behavior in Rhesus Macaque Females

J. D. Higley
S. T. King, Jr.
M. Linnoila
Research01 Jan 1996
Neuropsychopharmacology

Volume: 14, P: 67-76
MINA-1 and WAGO-4 are part of regulatory network coordinating germ cell death and RNAi in C. elegans

Ataman Sendoel
Deni Subasic
Michael O. Hengartner
Research06 Feb 2019
Cell Death & Differentiation

Volume: 26, P: 2157-2178
Lineage-specific STAT5 target gene activation in hematopoietic progenitor cells predicts the FLT3⁺-mediated leukemic phenotype

T A Müller
R Grundler
J Duyster
Research05 Apr 2016
Leukemia

Volume: 30, P: 1725-1733
Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses

Dual-specificity phosphatases (DUSPs) are a subclass of protein tyrosine phosphatases (PTPs) that interact with and regulate mitogen-activated protein kinases (MAPKs). DUSPs can positively or negatively control immune responses in cancers, infectious diseases and inflammatory diseases, making them promising drug targets for immune-based disorders.

Kate L. Jeffrey
Montserrat Camps
Charles R. Mackay
Reviews01 May 2007
Nature Reviews Drug Discovery

Volume: 6, P: 391-403
Compact all-optical precision-tunable narrowband hard Compton X-ray source

T. Brümmer
S. Bohlen
K. Põder
ResearchOpen Access26 Sept 2022
Scientific Reports

Volume: 12, P: 1-7
Cardiac-specific adipose triglyceride lipase overexpression protects from cardiac steatosis and dilated cardiomyopathy following diet-induced obesity

T Pulinilkunnil
P C Kienesberger
J R B Dyck
Research05 Jun 2013
International Journal of Obesity

Volume: 38, P: 205-215
BCR/ABL and IL-3 activate Rap1 to stimulate the B-Raf/MEK/Erk and Akt signaling pathways and to regulate proliferation, apoptosis, and adhesion

A Jin
T Kurosu
O Miura
Research06 Mar 2006
Oncogene

Volume: 25, P: 4332-4340
Expression and prognostic relevance of activated extracellular-regulated kinases (ERK1/2) in breast cancer

K Milde-Langosch
A-M Bamberger
T Löning
ResearchOpen Access31 May 2005
British Journal of Cancer

Volume: 92, P: 2206-2215
Gab2 signaling in chronic myeloid leukemia cells confers resistance to multiple Bcr-Abl inhibitors

F U Wöhrle
S Halbach
T Brummer
Research03 Aug 2012
Leukemia

Volume: 27, P: 118-129
Predictors of complications in gynaecological oncological surgery: a prospective multicentre study (UKGOSOC—UK gynaecological oncology surgical outcomes and complications)

R Iyer
A Gentry-Maharaj
U Menon
ResearchOpen Access23 Dec 2014
British Journal of Cancer

Volume: 112, P: 475-484
Gab2 is essential for Bcr-Abl-mediated leukemic transformation and hydronephrosis in a chronic myeloid leukemia mouse model

S Halbach
M Köhler
T Brummer
Correspondence29 Apr 2016
Leukemia

Volume: 30, P: 1942-1945
Cooperation of BRAF^F595L and mutant HRAS in histiocytic sarcoma provides new insights into oncogenic BRAF signaling

M Kordes
M Röring
S Fröhling
Research19 Nov 2015
Leukemia

Volume: 30, P: 937-946
Depletion of STAT5 blocks TEL–SYK-induced APMF-type leukemia with myelofibrosis and myelodysplasia in mice

C Sprissler
D Belenki
C Dierks
ResearchOpen Access22 Aug 2014
Blood Cancer Journal

Volume: 4, P: e240
MicroRNA-146a reduces MHC-II expression via targeting JAK/STAT signaling in dendritic cells after stem cell transplantation

N Stickel
K Hanke
R Zeiser
Research09 May 2017
Leukemia

Volume: 31, P: 2732-2741
The RhoGAP protein Deleted in Liver Cancer 3 (DLC3) is essential for adherens junctions integrity

G Holeiter
A Bischoff
M A Olayioye
ResearchOpen Access04 Jun 2012
Oncogenesis

Volume: 1, P: e13
Functional characterization of cancer-associated Gab1 mutations

C Ortiz-Padilla
D Gallego-Ortega
R J Daly
Research02 Jul 2012
Oncogene

Volume: 32, P: 2696-2702
Plant traits and vegetation data from climate warming experiments along an 1100 m elevation gradient in Gongga Mountains, China

Vigdis Vandvik
Aud H. Halbritter
Brian J. Enquist
ResearchOpen Access19 Jun 2020
Scientific Data

Volume: 7, P: 1-15
MAP3K11 is a tumor suppressor targeted by the oncomiR miR-125b in early B cells

U Knackmuss
S E Lindner
S Herzog
Research03 Jul 2015
Cell Death & Differentiation

Volume: 23, P: 242-252

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