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Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) suffer from limited maturation. Here the authors identify ERRγ agonist as a factor that enhances cardiac morphological, metabolic, contractile and electrical maturation of hiPSC-derived CMs with T-tubule formation.

Human pluripotent stem cells are differentiated into CD32b⁺ putative liver sinusoidal progenitors and liver bud organoids using an inverted multilayered air–liquid interface culture.

Recently, two oxidative enzymes have been reported to degrade extremely recalcitrant plastics, PVC and PE. Here, the authors show that these encouraging previous results could not be reproduced, and provide possible reasons for why the data may have been misinterpreted.

Light-driven sodium-pumping rhodopsins are unique ion transporters. Here, authors present a characterization of such rhodopsins with a modified active center allowing for efficient sodium transport under various environmental conditions.

Fujisawa and colleagues report that during a working memory task, firing patterns in ensembles of rat medial prefrontal cortex neurons reflect behavioral outcomes on coarser time scales and short-term synaptic plasticity on finer time scales. These results suggest that short-term plasticity plays a role in the neural computations guiding behavior.

The spatial separation of charge and spin densities in one-dimensional electron systems is the hallmark of Tomonaga–Luttinger physics. Waveform measurements now provide direct evidence for spin–charge separation.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Evolutionarily conserved gene modules mediate neurodegenerative dementia in a variety of mouse models and in postmortem brain tissue from patients.

Tumor-derived soluble PD-L1 drives immune checkpoint inhibitor (ICI) resistance and has recently been reported to be removed by therapeutic plasma exchange (TPE). Here, the authors report a phase I clinical trial investigating the combination of radiotherapy, TPE, and ICI rechallenge in patients with ICI-refractory metastatic melanoma with high PD-L1.

Charge fractionalization can be observed in artificial Tomonaga–Luttinger liquids by using a time-resolved electron transport experiment.

T-cell immunotherapies, such as CAR-T immunotherapy, are being developed against a wide variety of diseases. Here the authors report the feeder-free, scalable differentiation of human induced pluripotent cells (iPSCs) to T-cells with T-cell receptor dependent anti-tumour function in vitro and in vivo.

FLuID enables privacy-preserving knowledge sharing in drug discovery using knowledge distillation. The results show that the approach expands applicability domains and fosters collaboration across organizations without compromising data privacy or security.

This study identifies an altered chromatin conformation associated to a cardiac disorder observed in 7 independent families. A deletion of 2 diverging CTCF binding sites on 4q25 induces TAD fusion and leads to PITX2 expression dysregulation.

Cytotoxic CAR T cells derived from human induced pluripotent stem cells can be genetically engineered for enhanced proliferation and persistency in solid tumours.

A microcavity structure to which a periodic potential is applied has been designed, which effectively creates an array of weakly-coupled condensates. This allows the observation of fundamental dynamic behaviour, namely the build-up of certain superfluid-like states, which has been predicted for arrays of atomic Bose–Einstein condensates, but not yet observed.

This study uses gene expression predictors for the dorsolateral prefrontal cortex and other brain regions to perform a transcriptomic imputation analysis of schizophrenia, identifying 413 genic associations across 13 brain regions and 36 significantly enriched pathways.

In the worm, netrin and the TGFβ-related molecule UNC-129 form opposing dorsoventral gradients. Motor axons are repelled by netrin and attracted to UNC-129, but no TGFβ receptors appear to be involved in the attraction. This study shows that UNC-129 enhances repulsive signaling from the netrin receptor complex UNC-5/UNC-40, via a direct interaction with UNC-5.

The observation of so-called Bogoliubov excitations provides the first sign of possible superfluid behaviour in an exciton-polariton condensate.

The deposition of noble metals onto two-dimensional transition metal dichalcogenides is crucial for practical applications, including in catalysis and sensing, yet this process has remained difficult to control. Now, gold and silver have been shown to grow on colloidal transition metal dichalcogenide nanosheets into either atomically thin layers or nanoparticles whose sizes and morphologies depend on the relative strengths of the interfacial noble metal–chalcogen bonds.

Expression of Cas9 and gRNA from viral vectors in vivo may cause off-target activity. Here the authors present NanoMEDIC, which uses nanovesicles to transiently deliver editing machinery to hard-to-transfect cells.

The CommonMind Consortium sequenced RNA from dorsolateral prefrontal cortex of subjects with schizophrenia (N = 258) and control subjects (N = 279), creating a resource of gene expression and its genetic regulation. Using this resource, they found that ∼20% of schizophrenia loci have variants that may contribute to altered gene expression and liability.

A clinical decision support system for diagnosis of myocardial infarction, based on machine learning models that use a single measurement of high-sensitivity troponin, outperforms clinical guidelines that use fixed cardiac troponin thresholds for diagnosis.

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

A correlation between species and genetic diversity has been suggested. Here Baselga et al.provide evidence of a concordant decrease in beetle community similarity at species and genetic levels with geographic distance, suggesting a macroecological pattern which may follow neutral evolutionary processes.

Auxin-inducible degron systems can be leaky and require high doses of auxin. Here the authors establish AID2 which uses an OsTIR1 mutant and the ligand 5-Ph-IAA to overcome these problems and establish AID-mediated target depletion in mice.

The IFITM3 innate immunity protein directly binds presenilin near the active site and upregulates γ-secretase activity and the production of amyloid-β, and IFITM3 is upregulated in patients with late-onset Alzheimer’s disease.

Polygenic risk scores can predict susceptibility to drug-induced liver injury in patients and can stratify cellular viability of iPSC-derived liver organoids and primary hepatocytes from multiple donors.

Gamma-ray emission up to and above 100 TeV is detected from the supernova remnant G106.3+2.7. The emission above 10 TeV is associated with a molecular cloud rather than the pulsar PSR J2229+6114, favouring a hadronic origin via the π⁰ decay caused by accelerated relativistic protons.