The effect of the content of carboxy groups in oxidized cellulose nanofiber (CeNF) on hydroxyapatite (HAp) formation capability in biomimetic processing using a solution mimicking human body fluid (simulated body fluid; SBF) was systematically investigated. Oxidized CeNF with different carboxy group contents (0–27% per glucose units of cellulose) were soaked in 1.5SBF, in which concentration was 1.5 times higher than that of SBF. It was found that there was optimum amount of carboxy groups for the effective induction of HAp nucleation on CeNF.
- Seira Morimune-Moriya
- Sakina Kondo
- Chikara Ohtsuki
