Gasdermin E (GSDME) is abundantly expressed, but its physiological function remains unclear. Here, the authors show a non-pyroptotic function of GSDME in limiting renal inflammation during cisplatin nephrotoxicity by regulating O-GlcNAcylation and STAT3-S100A7A-RAGE signaling.
- Qingzhou Chen
- Pengxiao Sun
- Jing Nie