Dysregulation of angiogenesis and tubulointerstitial hypoxia is a common finding in renal disease. In this Review, the authors describe the process of vascular remodelling and its regulation by angiogenic factors and inhibitors. They explain the mechanisms by which angiogenesis and hypoxia in the kidney might lead to progression of renal disease and discuss the potential advantages and disadvantages of angiogenic and anti-angiogenic therapies as well as novel strategies to stabilize and generate healthy vasculature.
- Tetsuhiro Tanaka
- Masaomi Nangaku
