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Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

Plant roots host diverse fungal communities that affect plant health. Here, Mesny et al. use comparative genomics and transcriptomics of fungal isolates from the Arabidopsis thaliana root mycobiota, together with root colonization assays, to identify genetic determinants of endophytism.

TomoTwin is a deep metric learning-based particle picking method for cryo-electron tomograms. TomoTwin obviates the need for annotating training data and retraining a picking model for each protein.

Huber and colleagues utilize a multi-omic analytical pipeline to define an axis of proliferative drive involving mTOR, MYC and OXPHOS metabolic activity that is associated with disease heterogeneity and outcome in clinical cohorts of CLL.

Feeding industrial hemp silage affected feed intake, milk yield, respiratory and heart rates, and behaviour of dairy cows. Transfer of cannabinoids from feed to milk was investigated with liquid chromatography–tandem mass spectrometry and toxicokinetic computer modelling, and potential exposure to consumers explored.

Black carbon is a recalcitrant and unique form of organic carbon formed from incomplete combustion. Here the authors use global sampling to reduce uncertainty in the flux of terrestrial black carbon to the oceans, predicting that 34% of black carbon produced by fires has an oceanic fate.

Panos Deloukas, Nilesh Samani and colleagues report a large-scale association analysis using the Metabochip array in 63,746 coronary artery disease cases and 130,681 controls. They identify 15 susceptibility loci, refine previous associations and use network analysis to highlight biological pathways.

A specialized subpopulation of Yersinia entomophaga cells uses a RoeA-regulated, temperature- and pH-dependent type 10 secretion system to mediate lytic Tc toxin release.

A cryo-electron tomography study reports the structure of thick myosin filaments of mouse cardiac muscle in the relaxed state in situ and the MyBP-C links that connect them with the surrounding thin actin filaments.

A synthetic root microbial community rescues weak growth under low light and enhances immunity in Arabidopsis. Transcription factor MYC2 regulates both this coordination between rhizosphere and shoots and the growth/defence trade-off under low light conditions.

Thorsten Wagner et al. present SPHIRE-crYOLO, a particle picking software for selecting particles from digital micrographs in cryoEM data. After training, the method automatically recognizes particles with high recall and precision, simplifying data pre-processing.

Cryo-EM structures of F-actin captured in different nucleotide states, by using nucleotide analogs or small molecules, reveal different conformational states linked to ATP hydrolysis.

The interaction of two magnetic moments on a metallic surface is usually understood as a competition between an indirect surface-mediated exchange interaction and the Kondo effect. Now, a different mechanism, involving chemical interactions driving a quantum phase transition, is reported.

High-throughput single particle cryo-EM, for instance in drug research, requires the automation of the single particle analysis workflow. Here, the authors present TranSPHIRE, a software package that allows the fully-automated, feedback-driven processing of cryo-EM datasets during data acquisition.

The circadian clock and the cell cycle systems coordinate global physiology. Here the authors show that MYC represses the clock genes, together with MIZ1, and induces proliferation, suggesting that MYC inversely modulates cell cycle and circadian clock genes.

Reduced glomerular filtration rate (eGFR) is a hallmark of chronic kidney disease. Here, Pattaro et al. conduct a meta-analysis to discover several new loci associated with variation in eGFR and find that genes associated with eGFR loci often encode proteins potentially related to kidney development.

Primary lymphomas of the central nervous system (PCNSL) are defined as diffuse large B-cell lymphomas (DLBCL) confined to the CNS. Here, the authors complete whole genome sequencing and RNA-seq to characterize 51 PCNSLs, and find common mutations in immune pathways and upregulated TERT expression and find distinct pathway differences between DLBCL and other primary CNS lymphomas.

Automated single-particle picking in electron cryo-microscopy data has seen important advances in the past couple of years and now enables computer-assisted particle selection even for challenging datasets. These advances have implications for streamlined and automated image processing, with potential benefits for improving the resolution of resulting structures.

Analyses of genomes from 914 children, adolescents, and young adults provide a comprehensive resource of genomic alterations across a spectrum of common childhood cancers.

Burkitt lymphoma (BL) is the most common pediatric B-cell lymphoma. Here, within the International Cancer Genome Consortium, the authors performed whole genome and transcriptome sequencing of 39 sporadic BL, describing the landscape of mutations, structural variants, and mutational processes that underpin this disease how alterations on different cellular levels cooperate in deregulating key pathways and complexes.

Fragments of plastic smaller than 1 μm have raised concerns about the potential risks they pose to the environment. Research will have to answer a number of questions to establish what the realistic risks are.

Black carbon is produced by wildfire and fossil fuel burning, and persists in the environment over centuries to millennia. This Review describes black carbon sources and budgets, discusses its transport along the land-to-ocean continuum and highlights its enigmatic cycling in the ocean.

Wagner and Raunser recently presented a deep learning based particle picking program for Cryo-EM, crYOLO. Here they discuss recent improvements to the program, a graphical user interface and share their thoughts on desired future developments.

Temperature change over the past 2,000 years has shown pronounced regional variability. An assessment of all available continental temperature reconstructions shows a clear twentieth century warming trend, but no evidence of a coherent Little Ice Age or Medieval Warm Period.