TheC. elegans nervous system influences organismal lifespan but mechanistic details are poorly understood. Here, Chun et al. show that the neurotransmitter GABA regulates worm lifespan by acting on GABABreceptors in motor neurons, which activate the transcription factor DAF-16 in the intestine.
- Lei Chun
- Jianke Gong
- Jianfeng Liu
