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The study shows a micron-scale polariton structure where an artificial gauge field creates topological, non-reciprocal edge transport without strong magnetic fields, overcoming key limits for topological polariton lasers and devices.

Spin–orbit torques could enable a new generation of low-power electrically controlled memory devices. Here, the authors experimentally disentangle the spin-Hall effect and inverse spin-galvanic effect contributions to the relativistic spin torques in a room temperature Fe/(Ga,Mn)As bilayer.

The APOE-ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease, but it is not deterministic. Here, the authors show that common genetic variation changes how APOE-ε4 influences cognition.

Improved generation and manipulation of pure polariton spin transport over distances of tens of micrometres is a step towards spintronic applications.

Conductance quantization is the hallmark of non-interacting confined systems. The authors show that the quantization in graphene nanoconstrictions with low edge disorder is suppressed in the quantum Hall regime. This is explained by the addition of new conductance channels due to electrostatic screening.

The PCRCR complex of Plasmodium spp. binds basigin on the erythrocyte surface. While Rh5 of the complex is restricted to P. falciparum, PTRAMP, CSS and Ripr orthologs are present across the genus, for which the authors report common features.

GRX-810, an oxide dispersion strengthened alloy, shows excellent structural performance above 1100°C and stability up to 1300 °C. Grain-size effects, additive manufacturing–induced anisotropy, and fine trigonal Y₂O₃ particles enhance creep resistance.

A single-cell epigenomic atlas of human immune cells highlights cell-type-specific features associated with genetic or environmental exposures.

Achieving propagating topological exciton polaritons at room temperature is challenging. Here, the authors demonstrate room-temperature valley-polarized topological polaritons with valley-dependent propagation in a perovskite lattice formed by two mutually inverted honeycomb lattices with a bearded interface.

When interfaced with a current-carrying heavy metal, spin orbit effects can generate a torque on the magnetization of a ferromagnet, understood as a bulk effect. Here, the authors show evidence of an interfacial contribution to such spin orbit torque in O-doped W/CoFeB thin film systems.

Van der Waals heterostructures offer the potential of integrating multiple material layers into a single device to achieve new functionalities. Here, Ou et al combine ZrTe₂, a topological semimetal, with CrTe₂, a 2D ferromagnet, in a single heterostructure and demonstrate spin-orbit torque switching of the 2D ferromagnet by current in the topological semimetal.

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

Topological crystalline insulators are characterized by metallic states originating from crystal symmetries. A transistor device that takes advantage of the quantum properties of the topological crystalline insulating materials SnTe and Pb_1−xSn_xSe(Te) is now proposed.

Shifts in the seasonal timing of land surface warming set the severity of storm systems in the southern Great Plains since the last glacial, according to a hydroclimate proxy record from Texas and palaeoclimate modelling.

Strongly coupled light–matter systems could offer enhanced manipulation of topological phenomena. Now, tunable non-Hermitian effects are demonstrated with exciton–polaritons induced by a twist degree of freedom.

Here the authors show that tissue-resident memory and exhausted T cells in tumors are distinct populations that are shaped by relative presence or absence of TCR signals, suggesting that a tailored therapeutic strategy is needed to target each subset.

The Tomonaga–Luttinger liquid framework can be used to describe 1D quantum systems, spanning fermions, bosons and anyons. In this Review, we discuss the various platforms that can host TLL states, including Josephson junctions, cold atoms and topological materials, and discuss the advances TLL theory can provide in quantum criticality, nonequilibrium dynamics and condensed-matter physics exploration.

A room-temperature double-layer WS₂ microcavity is used to explore spin anisotropy and tune it with interlayer spacing.

Topologically protected states of matter are receiving widespread attention owing to their unusual electronic properties. Using numerical simulations, this study predicts that tin telluride is a physical realization of a new class of materials termed topological crystalline insulators.

Using well-calibrated statistical methods the authors jointly analyze Undiagnosed Diseases Network genomes, identifying known and novel disease genes. Software is publicly available to support future cross-cohort rare disease discovery efforts.

As presented at the ESMO Congress 2025: Results of the phase 2/3 AGITG DYNAMIC-III trial show that de-escalated chemotherapy based on ctDNA-negative status in patients with stage III colon cancer did not meet non-inferiority for 3-year recurrence-free survival when compared to standard of care, although it enables better informed treatment decisions.

The reliable assembly of two-dimensional materials into van der Waals heterostructures is a critical step towards nanoscale electronic integration. Here the authors present a technique for batch fabrication of graphene/boron nitride stacks with clean interfaces and high-yield.

How TNF regulates NK cell function and homeostasis is not fully understood. Here the authors investigate conditional knock out mice with TNFR1 and/or TNFR2 deficiency in NK cells upon bacterial infection, and identify that TNFR1 promotes cell death and impairs immunity while TNFR2 increases NK accumulation and enhances immunity.

Timothy Frayling, Joel Hirschhorn, Peter Visscher and colleagues report a meta-analysis of genome-wide association studies for adult height in 253,288 individuals. They identify 697 variants in 423 loci significantly associated with adult height and find that these variants cluster in pathways involved in growth and together explain one-fifth of the heritability for this trait.

Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

A novel antiviral targeting the SARS-CoV-2 PLpro protease shows strong efficacy in a mouse model, preventing lung pathology and reducing brain dysfunction. The study provides proof-of-principle that PLpro inhibition may be a viable strategy for preventing and treating long COVID.

In Bangladesh, 22 million people are exposed to hydrogeomorphic hazards, of which 86% have low levels of wealth. This study shows a statistically significant bias of populations with lower wealth levels living in hydrogeomorphically unstable areas.

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

External driving of Rabi oscillations is a first step in the coherent manipulation of spin systems. Here the authors use ultrafast optical pulses to produce classical Rabi oscillations in ferromagnetic CoFeB, enabling the exploration of coherent phenomena in dense ferromagnetic ensembles.

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

Here the authors provide an explanation for 95% of examined predicted loss of function variants found in disease-associated haploinsufficient genes in the Genome Aggregation Database (gnomAD), underscoring the power of the presented analysis to minimize false assignments of disease risk.

Researchers use a chimeric approach to reveal the first near-atomic resolution structures the yellow fever virion, showing key differences between vaccine and virulent strains that affect how antibodies recognise and neutralise the virus.

Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.

Cancers evolve as they progress under differing selective pressures. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, the authors present the method TrackSig the estimates evolutionary trajectories of somatic mutational processes from single bulk tumour data.

Dense nanostructuring of hBN-encapsulated graphene enables band structure engineering with distinct magnetotransport signatures and a tunable bandgap.

A pan-cancer genomic analysis reports the effects of structural variations on chromatin domains (TADs). Most TAD disruptions do not result in appreciable changes in expression of nearby genes.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

This overview of the ENCODE project outlines the data accumulated so far, revealing that 80% of the human genome now has at least one biochemical function assigned to it; the newly identified functional elements should aid the interpretation of results of genome-wide association studies, as many correspond to sites of association with human disease.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.