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Showing 1–50 of 582 results

Advanced filters: Author: Timothy Lane Clear advanced filters

Ediacaran Macro Body Fossils

Timothy Huang
Jei-Fu Shaw
ChuanWei Yang
ResearchOpen Access07 May 2010
Nature Precedings

P: 1
Genetic modifiers of APOE-ε4-associated cognitive decline

The APOE-ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease, but it is not deterministic. Here, the authors show that common genetic variation changes how APOE-ε4 influences cognition.

Alex G. Contreras
Skylar Walters
Timothy J. Hohman
ResearchOpen Access20 Feb 2026
Nature Communications

P: 1-17
SeqControl: process control for DNA sequencing

SeqControl uses 15 quality metrics of high-throughput sequencing experiments to predict how much sequencing is needed to reach a desired depth of coverage.

Lauren C Chong
Marco A Albuquerque
Paul C Boutros
Research31 Aug 2014
Nature Methods

Volume: 11, P: 1071-1075
Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors

Richard O. Snyder
Carol Miao
Mark A. Kay
Research01 Jan 1999
Nature Medicine

Volume: 5, P: 64-70
Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity

Patrick W. Gray
Bharat B. Aggarwal
Glenn E. Nedwin
Research20 Dec 1984
Nature

Volume: 312, P: 721-724
Reprogramming encapsulins into modular carbon-fixing nanocompartments

Installing algal pyrenoids or cyanobacterial carboxysomes into plants to enhance photosynthetic efficiency remains a formidable challenge. Here, the authors report the construction of CO₂-fixing nanocompartments by encapsulating Rubisco using encapsulin from Quasibacillus thermotolerans.

Taylor N. Szyszka
Davin S. Wijaya
Yu Heng Lau
ResearchOpen Access30 Oct 2025
Nature Communications

Volume: 16, P: 1-12
A role for ADP-ribosylation factor in nuclear vesicle dynamics

Annette L. Boman
Timothy C. Taylor
Katherine L. Wilson
Research06 Aug 1992
Nature

Volume: 358, P: 512-514
Phaseolin mRNA is translated to yield glycosylated polypeptides in Xenopus oocytes

Jayne A. Matthews
John W. S. Brown
Timothy C. Hall
Research12 Nov 1981
Nature

Volume: 294, P: 175-176
PDGF induction of tyrosine phosphorylation of GTPase activating protein

Christopher J. Molloy
Donald P. Bottaro
Stuart A. Aaronson
Research07 Dec 1989
Nature

Volume: 342, P: 711-714
Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex

Adrian Kelly
Stephen H. Powis
Alain Townsend
Research13 Feb 1992
Nature

Volume: 355, P: 641-644
B61 is a ligand for the ECK receptor protein-tyrosine kinase

Timothy D. Bartley
Robert W. Hunt
Gary M. Fox
Research07 Apr 1994
Nature

Volume: 368, P: 558-560
Multiple forms of dynamin are encoded by shibire, a Drosophila gene involved in endocytosis

Maio S. Chen
Robert A. Obar
Richard B. Vallee
Research13 Jun 1991
Nature

Volume: 351, P: 583-586
Breaking the menstruation taboo to make fieldwork more inclusive

We need to talk about periods when planning routine fieldwork trips, say ecologist Sarah E. Dalrymple and glaciologist Timothy P. Lane.

Sarah Dalrymple
Timothy Lane
Comments & Opinion09 Jan 2024
Nature
Divergent homeo box proteins recognize similar DNA sequences in Drosophila

Timothy Hoey
Michael Levine
Research28 Apr 1988
Nature

Volume: 332, P: 858-861
Mislocalization of ΔF508 CFTR in cystic fibrosis sweat gland

Norbert Kartner
Olga Augustinas
John R. Riordan
Research01 Aug 1992
Nature Genetics

Volume: 1, P: 321-327
Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6

Brian C. Varnum
Cynthia Young
Harvey K. Yamane
Research16 Feb 1995
Nature

Volume: 373, P: 623-626
Using virally expressed melanoma cDNA libraries to identify tumor-associated antigens that cure melanoma

Vaccination with a virus-expressed cDNA library derived from normal prostate cells can cure established prostate cancer in mouse models. Pulido et al. extend this approach and identify specific tumor-associated antigens from tumor-derived virus-expressed cDNA libraries that can be used in combination to cure established melanoma in mice.

Jose Pulido
Timothy Kottke
Richard Vile
Research18 Mar 2012
Nature Biotechnology

Volume: 30, P: 337-343
Expression of a transfected human c-myconcogene inhibits differentiation of a mouse erythroleukaemia cell line

Ethan Dmitrovsky
W. Michael Kuehl
Shoshana Segal
Research21 Aug 1986
Nature

Volume: 322, P: 748-750
Production and auto-induction of transforming growth factor-α in human keratinocytes

Robert J. Coffey Jr
Rik Derynck
Mark R. Pittelkow
Research27 Aug 1987
Nature

Volume: 328, P: 817-820
Small molecule splicing modulators that disrupt O-GlcNAc homeostasis

Authors report drug repurposing screens against O-GlcNAc cycling enzymes, finding kinase inhibitors that act as splicing modulators to disrupt O-GlcNAc homeostasis and downregulate OGT and OGA. These findings reveal splicing modulator chemotypes and approaches to disrupt O-GlcNAc homeostasis.

Steven S. Cheng
Alison C. Mody
Christina M. Woo
ResearchOpen Access12 Jan 2026
Nature Communications

Volume: 17, P: 1-17
Improved protein binder design using β-pairing targeted RFdiffusion

This study demonstrates the capability of deep learning protein design models in generating functionally validated β-strand pairing interfaces, expanding the structural diversity of de novo binding proteins and accessible target surfaces.

Isaac Sappington
Martin Toul
David Baker
ResearchOpen Access10 Jan 2026
Nature Communications

Volume: 17, P: 1-15
Autophagy-targeted NBR1–p62/SQSTM1 complexes promote breast cancer metastasis by sequestering ITCH

Mondal et al. report that autophagy inhibition promotes p63 activation and metastasis in breast cancer. This process depends on NBR1, which forms cytoplasmic p62/SQSTM1 condensates that sequester the ITCH ubiquitin ligase and prevents p63 degradation.

Gourish Mondal
Hugo Gonzalez
Jayanta Debnath
Research27 Jun 2025
Nature Cell Biology

Volume: 27, P: 1098-1113
Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery

Fumagalli et al. show that Sec62 delivers ER components to the autolysosome for clearance by acting as a receptor for autophagy protein LC3-II. This identifies Sec62 as a critical factor for selective ER turnover.

Fiorenza Fumagalli
Julia Noack
Maurizio Molinari
Research17 Oct 2016
Nature Cell Biology

Volume: 18, P: 1173-1184
Creating complex molecular topologies by configuring DNA four-way junctions

The synthesis of topologically non-trivial compounds requires the manipulation of molecular recognition with an extraordinarily high level of control. Now, DNA four-way junctions have been configured to construct synthetic DNA knots and links, which can then be used to investigate important DNA-processing enzymes.

Di Liu
Gang Chen
Yossi Weizmann
Research04 Jul 2016
Nature Chemistry

Volume: 8, P: 907-914
Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation

The transcription factor, serum response factor, SRF regulates critical smooth muscle (SM) contractile gene expression but what else controls SM differentiation is unclear. Here, Horita et al. demonstrate that nuclear PTEN acts with SRF at the transcriptional level to maintain the differentiated SM phenotype.

Henrick Horita
Christina L. Wysoczynski
Mary C. M. Weiser-Evans
ResearchOpen Access04 Mar 2016
Nature Communications

Volume: 7, P: 1-17
Structure and mechanism of the chromatin remodelling factor ISW1a

Kazuhiro Yamada
Timothy D. Frouws
Timothy J. Richmond
Research27 Apr 2011
Nature

Volume: 472, P: 448-453
Structural homology of a macrophage differentiation antigen and an antigen involved in T-cell-mediated killing

Konrad Kürzinger
May-Kin Ho
Timothy A. Springer
Research15 Apr 1982
Nature

Volume: 296, P: 668-670
Molecular cloning of foot and mouth disease virus genome and nucleotide sequences in the structural protein genes

John C. Boothroyd
Peter E. Highfield
Timothy J. R. Harris
Research30 Apr 1981
Nature

Volume: 290, P: 800-802
In vivo aminoacylation of brome mosaic and barley stripe mosaic virus RNAs

L. Sue Loesch-Fries
Timothy C. Hall
Research19 Aug 1982
Nature

Volume: 298, P: 771-773
Dissolve and capture: a strategy for analysing mRNA in blood

Messenger RNA (mRNA) sequences were amplified from whole blood prepared in guanidine thiocyanate (GuSCN) after capture of the mRNA with an affinity membrane.

David H. Gillespie
Kevin K. Cuddy
David I. Marks
Comments & Opinion27 Jan 1994
Nature

Volume: 367, P: 390-391
Sequence-specific DNA-binding activities of the gap proteins encoded by hunchback and Krüppel in Drosophila

Dusan Štanojević
Timothy Hoey
Michael Levine
Research28 Sept 1989
Nature

Volume: 341, P: 331-335
Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1

Donald E. Staunton
Michael L. Dustin
Timothy A. Springer
Research04 May 1989
Nature

Volume: 339, P: 61-64
A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS–family transcription factor, ERG

Poul H.B. Sorensen
Stephen L. Lessnick
Christopher T. Denny
Research01 Feb 1994
Nature Genetics

Volume: 6, P: 146-151
Biodiversity Quality: a paradigm for biodiversity

Alan Feest
Timothy Aldred
Katrin Jedamzik
ResearchOpen Access29 Apr 2009
Nature Precedings

P: 1
Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse

Timothy S Gomez
Michael J Hamann
Daniel D Billadeau
Research06 Feb 2005
Nature Immunology

Volume: 6, P: 261-270
Tumor-targeted, systemic delivery of therapeutic viral vectors using hitchhiking on antigen-specific T cells

Caroline Cole
Jian Qiao
Richard G Vile
Research18 Sept 2005
Nature Medicine

Volume: 11, P: 1073-1081
RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

Shi Du Yan
Xi Chen
Ann Marie Schmidt
Research22 Aug 1996
Nature

Volume: 382, P: 685-691
Molecular and biological characterization of a murine ligand for CD40

Richard J. Armitage
William C. Fanslow
Melanie K. Spriggs
Research07 May 1992
Nature

Volume: 357, P: 80-82
A new factor related to TATA-binding protein has highly restricted expression patterns in Drosophila

Thomas E. Crowley
Timothy Hoey
Robert Tjian
Research11 Feb 1993
Nature

Volume: 361, P: 557-561
PDGF- and insulin-dependent pp70^S6k activation mediated by phosphatidylinositol-3-OH kinase

Jongkyeong Chung
Timothy C. Grammar
John Blenis
Research07 Jul 1994
Nature

Volume: 370, P: 71-75
Anchoring mechanisms for LFA-3 cell adhesion glycoprotein at membrane surface

Michael L. Dustin
Periasamy Selvaraj
Timothy A. Springer
Research29 Oct 1987
Nature

Volume: 329, P: 846-848
Broad antigenic coverage induced by vaccination with virus-based cDNA libraries cures established tumors

Cancer vaccines are frequently designed to increase the immune response toward one or more of the few known tumor-associated antigens (TAAs). Kottke et al. describe an alternate approach to enhancing anti-tumor immune responses without the need for identification of specific TAAs. They show that systemic delivery of a vesicular stomatis virus–based cDNA library derived from normal tissue induces immune responses that impede growth of tumors of the same tissue type in mice.

Timothy Kottke
Fiona Errington
Richard Vile
Research19 Jun 2011
Nature Medicine

Volume: 17, P: 854-859
Carbon nanotube-assisted optical activation of TGF-β signalling by near-infrared light

TGF-β signalling, which is important in regulating various cellular processes during development, can be optically manipulated using near-infrared light with the aid of single-walled carbon nanotubes.

Liang Lin
Ling Liu
Xing Chen
Research16 Mar 2015
Nature Nanotechnology

Volume: 10, P: 465-471
G₀ is a major growth cone protein subject to regulation by GAP-43

Stephen M. Strittmatter
Dario Valenzuela
Mark C. Fishman
Research26 Apr 1990
Nature

Volume: 344, P: 836-841
Distinct organizations and patterns of expression of early and late histone gene sets in the sea urchin

Robert Maxson
Timothy Mohun
Larry Kedes
Research13 Jan 1983
Nature

Volume: 301, P: 120-125
Wnt-10b directs hypermorphic development and transformation in mammary glands of male and female mice

Timothy F Lane
Philip Leder
Research30 Oct 1997
Oncogene

Volume: 15, P: 2133-2144
Sequence homology of the LFA-1 and Mac-1 leukocyte adhesion glycoproteins and unexpected relation to leukocyte interferon

Timothy A. Springer
David B. Teplow
William J. Dreyer
Research11 Apr 1985
Nature

Volume: 314, P: 540-542
Biological properties of a CD4 immunoadhesin

Randal A. Byrn
Joyce Mordenti
Daniel J. Capon
Research12 Apr 1990
Nature

Volume: 344, P: 667-670
The major Fc receptor in blood has a phosphatidylinositol anchor and is deficient in paroxysmal nocturnal haemoglobinuria

Periasamy Selvaraj
Wendall F. Rosse
Timothy A. Springer
Research09 Jun 1988
Nature

Volume: 333, P: 565-567
Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs

Dysregulation of ribonucleoprotein complex granules, previously implicated in neuromuscular disease, can drive pathogenesis in a genetic form of dilated cardiomyopathy, as shown in gene-edited pigs and patient-derived cardiomyocytes.

Jay W. Schneider
Saji Oommen
Janell K. Fox
Research13 Nov 2020
Nature Medicine

Volume: 26, P: 1788-1800

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