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Showing 1–4 of 4 results
Advanced filters: Author: Tobias Derfuss Clear advanced filters
  • Dysregulated cytokine networks are important in the pathogenesis of neuroinflammation. This Review discusses targeting cytokines and their receptors in non-infectious central nervous system inflammatory diseases such as multiple sclerosis and neurosarcoidosis, as well as in the neurotoxic adverse events that can be triggered by cancer immunotherapy.

    • Burkhard Becher
    • Tobias Derfuss
    • Roland Liblau
    Reviews
    Nature Reviews Drug Discovery
    Volume: 23, P: 862-879
  • Increasing evidence supports a role for B cells and antibodies in the pathogenesis of multiple sclerosis (MS). Here, Meinl and colleagues discuss the proinflammatory contribution of B-cell signalling in MS, and consider potential targets of autoantibodies. The B-cell response to various MS therapies is also summarized.

    • Markus Krumbholz
    • Tobias Derfuss
    • Edgar Meinl
    Reviews
    Nature Reviews Neurology
    Volume: 8, P: 613-623
  • Autologous haematopoietic stem cell transplantation (AHSCT) is a treatment option for some forms of multiple sclerosis (MS), but uncertainties remain about its implementation in clinical practice and treatment protocols need to be optimized. This Consensus Statement provides guidance and recommendations for the use of AHSCT in MS and neuromyelitis optica spectrum disorders.

    • Paolo A. Muraro
    • Alice Mariottini
    • Helene Zephir
    Reviews
    Nature Reviews Neurology
    Volume: 21, P: 140-158
  • A machine learning approach using high-dimensional phenotypic and functional profiling data identifies a multiple sclerosis-specific T cell population that is reduced following treatment.

    • Edoardo Galli
    • Felix J. Hartmann
    • Burkhard Becher
    Research
    Nature Medicine
    Volume: 25, P: 1290-1300