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Showing 1–50 of 190 results

Advanced filters: Author: Toshio Suzuki Clear advanced filters

‘Glycerol Effect’ and the Mechanism Linking Excitation of the Plasma Membrane with Contraction

MASAHIRO FUJINO
TOSHIO YAMAGUCHI
KEISHI SUZUKI
Research23 Dec 1961
Nature

Volume: 192, P: 1159-1161
Highly Fractionated Nuclear Debris Resulting from the Venting of a Soviet Underground Nuclear Test

SEITARO KOYAMA
TAKESHI SOTOBAYASHI
TOSHIO SUZUKI
Research15 Jan 1966
Nature

Volume: 209, P: 239-240
Prevention of graft coronary arteriosclerosis by antisense cdk2 kinase oligonucleotide

Jun-Ichi Suzuki
Mitsuaki Isobe
Morie Sekiguchi
Research01 Aug 1997
Nature Medicine

Volume: 3, P: 900-903
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Short-range Dating of Fresh Nuclear Debris

TAKESHI SOTOBAYASHI
TOSHIO SUZUKI
SEITARO KOYAMA
Research01 Aug 1967
Nature

Volume: 215, P: 728-729
Sliding distance of actin filament induced by a myosin crossbridge during one ATP hydrolysis cycle

Toshio Yanagida
Toshiaki Arata
Fumio Oosawa
Research25 Jul 1985
Nature

Volume: 316, P: 366-369
Application of High-Tension Annealing to Nylon 46 Fibers

Akihiro Suzuki
Akira Endo
Toshio Kunugi
Research01 Apr 1998
Polymer Journal

Volume: 30, P: 275-280
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
Synthesis of Polydimethylsiloxanes Containing Aminosilyl or Amidosilyl Groups at One Chain End

Toshio Suzuki
Shuji Yamada
Tadashi Okawa
Research01 Apr 1993
Polymer Journal

Volume: 25, P: 411-416
Inter-hemispheric Transfer of Fresh Debris from French Nuclear Tests in 1968

TAKESHI SOTOBAYASHI
TOSHIO SUZUKI
AKRIA FURUSAWA
Research13 Dec 1969
Nature

Volume: 224, P: 1096-1097
Staphylococcus aureus ST764-SCCmecII high-risk clone in bloodstream infections revealed through national genomic surveillance integrating clinical data

Authors present results from a national surveillance in Japan that found MRSA strains causing bloodstream infections are predominantly from three clonal lineages. They also identified the emergence of highest 30-day-mortality MRSA clone ST764-SCCmecII and traced its evolutionary path.

Junzo Hisatsune
Shoko Kutsuno
Motoyuki Sugai
ResearchOpen Access19 Mar 2025
Nature Communications

Volume: 16, P: 1-14
Analysis of the HLA-DRw9 antigen using two-dimensional gel electrophoresis and alloantisera

Toshio Yabe
Manabu Suzuki
Hideo Hamaguchi
Research01 Mar 1984
Japanese Journal of Human Genetics

Volume: 29, P: 17-25
Na⁺-V-ATPase inhibitor curbs VRE growth and unveils Na⁺ pathway structure

The authors identify V-161, a compound that inhibits enterococcal Na⁺-V-ATPase and reduces VRE colonization in mice. The high-resolution structure of V-161 reveals its action on the Na+ transport pathway, offering new therapeutic insights.

Kano Suzuki
Yoshiyuki Goto
Takeshi Murata
Research21 Nov 2024
Nature Structural & Molecular Biology

Volume: 32, P: 450-458
Does cyclic GMP mediate the slow excitatory synaptic potential in sympathetic ganglia?

TOSHIO HASHIGUCHI
NAKAKO S. USHIYAMA
BENJAMIN LIBET
Research01 Jan 1978
Nature

Volume: 271, P: 267-268
Survival days of patients with metastatic spinal tumors of lung cancer requiring surgery: a prospective multicenter study

Takuya Takahashi
Takashi Hirai
Takeo Furuya
ResearchOpen Access06 Jul 2025
Scientific Reports

Volume: 15, P: 1-7
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
The Combination Therapy of Hypertension to Prevent Cardiovascular Events (COPE) Trial: Rationale and Design

Toshio Ogihara
Masunori Matsuzaki
Takao Saruta
Research01 Apr 2005
Hypertension Research

Volume: 28, P: 331-338
DNA typing of HLA in the patients with moyamoya disease

Takuya K. Inoue
Kiyonobu Ikezaki
Masashi Fukui
Research01 Dec 1997
Japanese Journal of Human Genetics

Volume: 42, P: 507-515
Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning

Tatsuya Yoshizawa
Yuki Handa
Shigeaki Kato
Research01 Aug 1997
Nature Genetics

Volume: 16, P: 391-396
Author Correction: An ensemble method for improving robustness against the electrode contact problems in automated sleep stage scoring

Kazumasa Horie
Ryusuke Miyamoto
Hiroyuki Kitagawa
Amendments and CorrectionsOpen Access21 Jan 2025
Scientific Reports

Volume: 15, P: 1
Primary Aldosteronism Caused by a Unilateral Adrenal Adenoma Accompanied by Autonomous Cortisol Secretion

Jiro Suzuki
Fumio Otsuka
Hirofumi Makino
Research01 Apr 2007
Hypertension Research

Volume: 30, P: 367-373
Palladium(0)-catalyzed Synthesis of Unsaturated Polyethers from Bifunctional Vinyloxiranes and Bisphenol Analogues

Toshio Koizumi
Tadayoshi Akita
Takeshi Endo
Research10 Aug 2004
Polymer Journal

Volume: 36, P: 647-651
A 3′ splice site consensus sequence mutation in the intron 3 of the α-galactosidase a gene in a patient with Fabry disease

Tohru Yokoi
Kazuko Shinoda
Noboru Taniguchi
Research24 Jun 2005
Japanese journal of human genetics

Volume: 36, P: 245-250
Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Mammalian genomes are scattered with repetitive sequences, but their biology remains largely elusive. Here, the authors show that transcription can initiate from short tandem repetitive sequences, and that genetic variants linked to human diseases are preferentially found at repeats with high transcription initiation level.

Mathys Grapotte
Manu Saraswat
Charles-Henri Lecellier
ResearchOpen Access02 Jun 2021
Nature Communications

Volume: 12, P: 1-18
Pleofungins, Novel Inositol Phosphorylceramide Synthase Inhibitors, from Phoma sp. SANK 13899

Azusa Aoyagi
Tatsuya Yano
Toshio Takatsu
Research01 Feb 2007
The Journal of Antibiotics

Volume: 60, P: 143-152
Design of complicated all-α protein structures

Here authors developed a computational method to design complicated all-α structures using typical helix–loop–helix motifs and canonical α-helices, and demonstrated the ability to create complicated all-α proteins.

Koya Sakuma
Naohiro Kobayashi
Nobuyasu Koga
ResearchOpen Access04 Jan 2024
Nature Structural & Molecular Biology

Volume: 31, P: 275-282
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Genetic determinants of risk in autoimmune pulmonary alveolar proteinosis

Autoimmune pulmonary alveolar proteinosis (aPAP) is a complex lung disease caused by abnormal surfactant homeostasis. Here, the authors carry out a genome-wide association study of aPAP in a Japanese cohort, finding variants in the MHC and suggesting predisposition to abnormal antibody production.

Saori Sakaue
Etsuro Yamaguchi
Yukinori Okada
ResearchOpen Access15 Feb 2021
Nature Communications

Volume: 12, P: 1-6
Colletoic Acid, a Novel 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor from Colletotrichum gloeosporioides SANK 21404

Azusa Aoyagi
Mariko Ito-Kobayashi
Toshio Takatsu
Research01 Mar 2008
The Journal of Antibiotics

Volume: 61, P: 136-141
The significance of adding posterior decompression to spine stabilization in metastatic spinal surgery: a multicenter prospective study

Hiroyuki Tominaga
Ichiro Kawamura
Takeo Furuya
ResearchOpen Access29 Jul 2025
Scientific Reports

Volume: 15, P: 1-15
Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors

Leukemic stem cells (LSCs) in chronic myeloid leukemia are resistant to imatinib and therefore are a cause of relapse. The authors show that IRAK1/4-NF-κB-PD-L1 signaling is critical to mediate imatinib resistance in LSCs and that combining imatinib with blocking this signalling pathway can eliminate LSCs.

Yosuke Tanaka
Reina Takeda
Toshio Kitamura
ResearchOpen Access12 Jan 2022
Nature Communications

Volume: 13, P: 1-13
Antihypertensive Efficacy and Safety of Fixed-Dose Combination Therapy with Losartan plus Hydrochlorothiazide in Japanese Patients with Essential Hypertension

Takao Saruta
Toshio Ogihara
Kihito Takahashi
Research01 Aug 2007
Hypertension Research

Volume: 30, P: 729-739
Synthesis and Properties of Helical Poly(macromonomer) Consisting of Polyacetylene Main Chain and Poly(methyl methacrylate) Side Chains

Masashi Shiotsuki
Wei Zhang
Toshio Masuda
Research16 May 2007
Polymer Journal

Volume: 39, P: 690-695
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Fabrication of Depth-controllable Nanochannel with Polymer Nanoassembled Films Using Atomic Force Microscopy Lithography

Takeshi Mikayama
Toshio Suzuki
Tokuji Miyashita
Research07 Nov 2005
Polymer Journal

Volume: 37, P: 854-857
Macrophage Inflammatory Protein-1α Relates to the Recruitment of Inflammatory Cells in Myosin-Induced Autoimmune Myocarditis in Rats

Tetsuya Toyozaki
Toshihiro Saito
Michiaki Hiroe
Research01 Jul 2001
Laboratory Investigation

Volume: 81, P: 929-936
A fluorescent variant of a protein from the stony coral Montipora facilitates dual-color single-laser fluorescence cross-correlation spectroscopy

Takako Kogure
Satoshi Karasawa
Atsushi Miyawaki
Research30 Apr 2006
Nature Biotechnology

Volume: 24, P: 577-581
Clinical Efficacy of a New Angiotensin II Type 1 Receptor Blocker, Pratosartan, in Hypertensive Patients

Toshio Ogihara
Takao Saruta
Hiromi Rakugi
Research01 Feb 2008
Hypertension Research

Volume: 31, P: 281-287
Aliskiren, a Novel Oral Renin Inhibitor, Provides Dose-Dependent Efficacy and Placebo-Like Tolerability in Japanese Patients with Hypertension

Toshio Kushiro
Hiroshige Itakura
Deborah L Keefe
Research01 Dec 2006
Hypertension Research

Volume: 29, P: 997-1005
The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line

The FANTOM4 study identified transcriptional start sites active during proliferation arrest and differentiation of the human monocytic cell line THP-1. Systematic knockdown of 52 transcription factors provide support for their model in which a complex transcriptional network regulates the differentiation process.

Harukazu Suzuki
Alistair R R Forrest
Yoshihide Hayashizaki
Research19 Apr 2009
Nature Genetics

Volume: 41, P: 553-562
Pleofungins, Novel Inositol Phosphorylceramide Synthase Inhibitors, from Phoma sp. SANK 13899

Tatsuya Yano
Azusa Aoyagi
Masatoshi Inukai
Research01 Feb 2007
The Journal of Antibiotics

Volume: 60, P: 136-142
Erratum: Additions and Corrections

Toshio Ogihara
Masunori Matsuzaki
Keishi Abe
Amendments and Corrections01 Aug 2006
Hypertension Research

Volume: 29, P: 639
Design and Baseline Characteristics of an Observational Study in Japanese Patients with Hypertension: Japan Hypertension Evaluation with Angiotensin II Antagonist Losartan Therapy (J-HEALTH)

Hiroaki Naritomi
Toshiro Fujita
Nobuo Yoshiike
Research01 Sept 2007
Hypertension Research

Volume: 30, P: 807-814
Impact of Blood Pressure Control on Cardiovascular Events in 26,512 Japanese Hypertensive Patients: The Japan Hypertension Evaluation with Angiotensin II Antagonist Losartan Therapy (J-HEALTH) Study, a Prospective Nationwide Observational Study

Kazuaki Shimamoto
Toshiro Fujita
Nobuo Yoshiike
Research01 Mar 2008
Hypertension Research

Volume: 31, P: 469-478
The Importance of Home Blood Pressure Measurement for Preventing Stroke and Cardiovascular Disease in Hypertensive Patients: A Sub-Analysis of the Japan Hypertension Evaluation with Angiotensin II Antagonist Losartan Therapy (J-HEALTH) Study, a Prospective Nationwide Observational Study

Kazuyuki Shimada
Toshiro Fujita
Nobuo Yoshiike
Research01 Oct 2008
Hypertension Research

Volume: 31, P: 1903-1911
Efficacy and Safety of Long-Term Losartan Therapy Demonstrated by a Prospective Observational Study in Japanese Patients with Hypertension: The Japan Hypertension Evaluation with Angiotensin II Antagonist Losartan Therapy (J-HEALTH) Study

Hiroaki Naritomi
Toshiro Fujita
Nobuo Yoshiike
Research01 Feb 2008
Hypertension Research

Volume: 31, P: 295-304
Complete sequencing and characterization of 21,243 full-length human cDNAs

Toshio Ota
Yutaka Suzuki
Sumio Sugano
Research21 Dec 2003
Nature Genetics

Volume: 36, P: 40-45
Polymerization of (o-Phenylphenyl)acetylene and (2,5-Di-tert-butylphenyl)-acetylene and Polymer Properties

Toshio Masuda
Yoshiharu Abe
Toshinobu Higashimura
Research01 Mar 1994
Polymer Journal

Volume: 26, P: 393-395

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